What Is Certain in the Treatment with Immunoglobulins?

Effects of early treatment with immunoglobulin on critical illness polyneuropathy following multiple organ failure and gram-negative sepsis

“…IVIG may modify the immunological cascade in sepsis and restore compromised defense systems [25]. However, in the past the varying results of several clinical studies assessing the beneficial effect of adjunctive immunoglobulin treatment in sepsis have been disappointing [26]. For the first time two recent studies confirmed the efficacy of IVIG by reducing the mortality rate of patients with severe sepsis [27] and gram-negative shock [28].…”

“…For the first time two recent studies confirmed the efficacy of IVIG by reducing the mortality rate of patients with severe sepsis [27] and gram-negative shock [28]. Nevertheless, the therapeutic value of IVIG in human sepsis still has to be confirmed substantially [24,26].…”