What I got wrong about shelterin

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doi:10.1074/jbc.aw118.003234

Cited by 8 publications

(4 citation statements)

References 38 publications

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“…This protection implies the distinction between natural chromosome ends from accidental DNA breaks, avoiding the unwanted action of the repairing machinery on telomeres. In humans, this set of telomere-binding proteins, a complex known as shelterin, include TRF1, TRF2, POT1, and other proteins that interact with telomeres indirectly (De Lange, 2005, 2018. Besides its protective function, the shelterin complex also Common, but absent in some chromosomes and species.…”

Section: The Structure and Function Of Chromosome Endsmentioning

confidence: 99%

Telomeres and Subtelomeres Dynamics in the Context of Early Chromosome Interactions During Meiosis and Their Implications in Plant Breeding

Aguilar

Prieto

2021

Front. Plant Sci.

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Genomic architecture facilitates chromosome recognition, pairing, and recombination. Telomeres and subtelomeres play an important role at the beginning of meiosis in specific chromosome recognition and pairing, which are critical processes that allow chromosome recombination between homologs (equivalent chromosomes in the same genome) in later stages. In plant polyploids, these terminal regions are even more important in terms of homologous chromosome recognition, due to the presence of homoeologs (equivalent chromosomes from related genomes). Although telomeres interaction seems to assist homologous pairing and consequently, the progression of meiosis, other chromosome regions, such as subtelomeres, need to be considered, because the DNA sequence of telomeres is not chromosome-specific. In addition, recombination operates at subtelomeres and, as it happens in rye and wheat, homologous recognition and pairing is more often correlated with recombining regions than with crossover-poor regions. In a plant breeding context, the knowledge of how homologous chromosomes initiate pairing at the beginning of meiosis can contribute to chromosome manipulation in hybrids or interspecific genetic crosses. Thus, recombination in interspecific chromosome associations could be promoted with the aim of transferring desirable agronomic traits from related genetic donor species into crops. In this review, we summarize the importance of telomeres and subtelomeres on chromatin dynamics during early meiosis stages and their implications in recombination in a plant breeding framework.

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Section: The Structure and Function Of Chromosome Endsmentioning

confidence: 99%

Telomeres and Subtelomeres Dynamics in the Context of Early Chromosome Interactions During Meiosis and Their Implications in Plant Breeding

Aguilar

Prieto

2021

Front. Plant Sci.

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“…The third shelterin subunit, POT1 was not included as it has already been examined in the endometrium [ 47 ]. TERF2IP was included in our study as it binds to TERF2, therefore is structurally relevant [ 48 ]. TERF1/2 and TERF2IP proteins which were non-prognostic according to TCGA data, they were also included for study validation.…”

Section: Resultsmentioning

confidence: 99%

Telomere and Telomerase-Associated Proteins in Endometrial Carcinogenesis and Cancer-Associated Survival

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Rogers

Thomas

et al. 2022

IJMS

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Risk of relapse of endometrial cancer (EC) after surgical treatment is 13% and recurrent disease carries a poor prognosis. Research into prognostic indicators is essential to improve EC management and outcome. “Immortality” of most cancer cells is dependent on telomerase, but the role of associated proteins in the endometrium is poorly understood. The Cancer Genome Atlas data highlighted telomere/telomerase associated genes (TTAGs) with prognostic relevance in the endometrium, and a recent in silico study identified a group of TTAGs and proteins as key regulators within a network of dysregulated genes in EC. We characterise relevant telomere/telomerase associated proteins (TTAPs) NOP10, NHP2, NOP56, TERF1, TERF2 and TERF2IP in the endometrium using quantitative polymerase chain reaction (qPCR) and immunohistochemistry (IHC). qPCR data demonstrated altered expression of multiple TTAPs; specifically, increased NOP10 (p = 0.03) and reduced NHP2 (p = 0.01), TERF2 (p = 0.01) and TERF2IP (p < 0.003) in EC relative to post-menopausal endometrium. Notably, we report reduced NHP2 in EC compared to post-menopausal endometrium in qPCR and IHC (p = 0.0001) data; with survival analysis indicating high immunoscore is favourable in EC (p = 0.0006). Our findings indicate a potential prognostic role for TTAPs in EC, particularly NHP2. Further evaluation of the prognostic and functional role of the examined TTAPs is warranted to develop novel treatment strategies.

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“…Proteins that bind along the repeating path of telomeric DNA (TRF1 and TRF2 bind to double-stranded DNA regions, POT1 and TPP1 bind to single-stranded DNA regions) attach additional proteins (TIN2 and Pap1), which do not have, at least in humans, DNAbinding sites, and form a high-order nucleoprotein complex, which has been called shelterin. [5,6] (Figure 1).…”

Section: Telomeresmentioning

confidence: 99%

Role of Telomeres Shortening in Atherogenesis: An Overview

Yegorov

Poznyak

Nikiforov

et al. 2021

Cells

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It is known that the shortening of the telomeres leads to cell senescence, accompanied by acquiring of pro-inflammatory phenotype. The expression of telomerase can elongate telomeres and resist the onset of senescence. The initiation of atherosclerosis is believed to be associated with local senescence of the endothelial cells of the arteries in places with either low or multidirectional oscillatory wall shear stress. The process of regeneration of the artery surface that has begun does not lead to success for several reasons. Atherosclerotic plaques are formed, which, when developed, lead to fatal consequences, which are the leading causes of death in the modern world. The pronounced age dependence of the manifestations of atherosclerosis pushes scientists to try to link the development of atherosclerosis with telomere length. The study of the role of telomere shortening in atherosclerosis is mainly limited to measuring the telomeres of blood cells, and only in rare cases (surgery or post-mortem examination) are the telomeres of local cells available for measurement. The review discusses the basic issues of cellular aging and the interpretation of telomere measurement data in atherosclerosis, as well as the prospects for the prevention and possible treatment of atherosclerosis.

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What I got wrong about shelterin

Cited by 8 publications

References 38 publications

Telomeres and Subtelomeres Dynamics in the Context of Early Chromosome Interactions During Meiosis and Their Implications in Plant Breeding

Telomeres and Subtelomeres Dynamics in the Context of Early Chromosome Interactions During Meiosis and Their Implications in Plant Breeding

Telomere and Telomerase-Associated Proteins in Endometrial Carcinogenesis and Cancer-Associated Survival

Role of Telomeres Shortening in Atherogenesis: An Overview

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