“…There are seminal examples of case reports in the medical literature that have antecedently addressed the beneficial or adverse effects of treatment protocols in specific clinical entities such as the relationship between phocomelia and thalidomide, or propranolol treatment for infantile hemangioma ( 4 , 5 ). Despite, however, the numerous contributions of case reports to the medical literature, controversies have emerged among the scientific community regarding their varying quality and level of evidence, especially in the last 20 years ( 6 ).…”