What has been learnt from study of dopamine receptors in Parkinson's disease?

Hurley, Michael J.; Jenner, Peter

doi:10.1016/j.pharmthera.2005.12.001

Cited by 98 publications

(87 citation statements)

References 158 publications

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“…In progressively MPTPlesioned monkeys, Drd2 receptor binding is initially decreased, followed by later upregulation (Bezard et al, 2001). The biphasic pattern of Drd2 expression in that report and in our study may reflect paucity of presynaptic Drd2 receptors (Hurley and Jenner 2006) due to failed development of nigrostriatal projections (Nunes et al, 2003) followed by postsynaptic upregulation.…”

Section: Discussionsupporting

confidence: 59%

“…In animals, declining Drd3 receptors are associated with motor dysfunction, while increasing Drd3 levels accompany levodopa therapy (Quik et al, 2000) or functional recovery (Wade et al, 2001). Either increased or decreased D3 levels are reported in human patients (Hurley and Jenner 2006). Declining striatal expression of Drd1a and Drd4 in our ak mice are difficult to interpret in the light of published findings.…”

Section: Discussionmentioning

confidence: 76%

“…Increased striatal expression of Drd2a is commonly reported in human postmortem (Hurley and Jenner 2006;Joyce 1993;Piggott et al, 1999;Ryoo et al, 1998) and functional studies (Kim et al, 2002;Thobois et al, 2004) of PD, as well as in animal models (Morissette et al 1998;Guillin et al 2001). We did not identify an absolute increase in Drd2 expression in our ak mice.…”

Section: Discussionmentioning

confidence: 98%

“…These arise from the combined effects of progressive dopaminergic denervation and chronic levodopa therapy (Olanow et al, 2006). Both result in adaptive changes in striatal neurochemistry that, together, are thought to result in motor fluctuations and dyskinesias seen in treated patients (Jenner, 2000;Calon and Di Paolo 2002;Guigoni et al, 2005;Hurley and Jenner 2006;Linazasoro, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…Striatal denervation in PD is accompanied by a host of secondary neurochemical alterations in dopaminergic receptors (Hurley and Jenner 2006) as well as in striatal glutaminergic (Kashani et al, 2007), serotonergic (Di Giovanni et al, 2006), cholinergic (Zhou et al, 2003) systems and neuropeptides (Backman et al, 2007). The Pitx3 −/− or aphakia (ak) mouse is a promising model of striatal denervation in PD as it exhibits the cell specificity of neurodegeneration observed in humans (Hwang et al, 2003;Nunes et al, 2003;Smidt et al, 2004), similar neuroadaptive phenomena at the level of the striatum (Smits et al, 2005;van den Munckhof et al, 2006), and locomotor deficits that are rescued by levodopa van den Munckhof et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Motor deficits and altered striatal gene expression in aphakia (ak) mice

et al. 2007

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Like humans with Parkinsons disease (PD), the ak mouse lacks the majority of the substantia nigra pars compacta (SNc) and experiences striatal denervation. The purpose of this study was to test whether motor abnormalities in the ak mouse progress over time, and whether motor function could be associated with temporal alterations in the striatal transcriptome. Ak and wt mice (28 to 180 days old) were tested using paradigms sensitive to nigrostriatal dysfunction. Results were analyzed using a linear mixed model. Ak mice significantly underperformed wt controls in rotarod, balance beam, string test, pole test and cotton shred tests at all ages examined. Motor performance in ak mice remained constant over the first 6 months of life, with the exception of the cotton shred test, in which ak mice exhibited marginal decline in performance. Dorsal striatal semi-quantitative RT-PCR for 19 dopaminergic, cholinergic, glutaminergic and catabolic genes was performed in 1 and 6 month old groups of ak and wt mice. Preproenkephalin levels in ak mice were elevated in both age groups. Drd1, 3 and 4 levels declined over time, in contrast to increasing Drd2 expression. Additional findings included decreased Chrnα6 expression and elevated VGluT1 expression at both time points in ak mice, and elevated AchE expression in young ak mice only. Results confirm that motor ability does not decline significantly for the first 6 months of life in ak mice. Their striatal gene expression patterns are consistent with dopaminergic denervation, and change over time, despite relatively unaltered motor performance.

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Motor deficits and altered striatal gene expression in aphakia (ak) mice

et al. 2007

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Mammal Hip Morphology and Function: Coxa Recta and Coxa Rotunda

Bouma

Boer

Vos

et al. 2012

The Anatomical Record

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Using 15 parameters, we provide a systematic description of mammal proximal femoral morphology. We established two types of proximal femoral morphology, termed coxa recta and coxa rotunda, characterized by low versus high concavity of the head-neck junction. Concavity is a measure of the sphericity of the femoral head as it meets the femoral neck that can be quantified by angular measurements. We asked whether the parameter of concavity corresponds with the classification of mammal proximal femoral morphology based on coalesced versus separate ossification patterns and locomotor patterns. Statistical analysis demonstrated a distinction between coxa recta and coxa rotunda with significant differences between the two groups in all but 3 of the 15 parameters examined. We found the most discriminating measurement between mammal hips to be the concavity of the posterior head-neck junction (beta angle). Coxa recta (small concavity) and coxa rotunda (large concavity) relate to the ossification pattern seen in proximal femoral development, and species-specific patterns of locomotion. We interpret the two hip types to reflect optimization for strength (recta) versus mobility (rotunda). Conceptually, both hip types can be recognized in humans, where coxa recta can be related to the development of osteoarthritis.

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Retracted: Terbium‐sensitized fluorescence method for the determination of dopamine in biological fluids and tablet formulation

et al. 2012

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The following article from Luminescence, Terbium‐sensitized fluorescence method for the determination of dopamine in biological fluids and tablet formulation by Vahid Shahinfard, Ali Ehsani, Vahid Panahi‐Azar, Negar Kabir Yousefi and Morteza Salek Jalali, published online on 12th January 2012 in Wiley Online Library (http://www.onlinelibrary.wiley.com), has been retracted by agreement between the authors, the journal Editor in Chief, Professor L. J. Kricka and Wiley‐Blackwell. The retraction has been agreed due to data in the article is not being reproducible. Copyright © 2012 John Wiley & Sons, Ltd.

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What has been learnt from study of dopamine receptors in Parkinson's disease?

Cited by 98 publications

References 158 publications

Motor deficits and altered striatal gene expression in aphakia (ak) mice

Motor deficits and altered striatal gene expression in aphakia (ak) mice

Mammal Hip Morphology and Function: Coxa Recta and Coxa Rotunda

Retracted: Terbium‐sensitized fluorescence method for the determination of dopamine in biological fluids and tablet formulation

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