What has been Learned from the Studies of Oxidative Stress-induced Carcinogenesis: Proposal of the Concept of Oxygenomics

Toyokuni, Shinya; Akatsuka, Shinya

doi:10.3164/jcbn.39.3

Cited by 29 publications

(23 citation statements)

References 79 publications

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“…29,30 In the edge region of the helium APP jet, it was reported that the ambient air was mixed in the plasma and the amount of the ROS was increased. 29,30 In the edge region of the helium APP jet, it was reported that the ambient air was mixed in the plasma and the amount of the ROS was increased.…”

Section: B Experimental Resultsmentioning

confidence: 99%

Improvement of cell membrane permeability using a cell-solution electrode for generating atmospheric-pressure plasma

et al. 2015

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The cell membrane permeability, which is strongly related to gene transfection, is improved using a cell-solution electrode for generating atmospheric-pressure plasma (APP) just above the solution. In the case of the floating cells, the cell membrane permeability is significantly improved by the cell-solution electrode APP compared with the conventional diffusion type APP, because the distance between the plasma generation area and the cell solution surface becomes short, which could reduce the radial diffusion loss of the plasma irradiated to the cell suspended solution. In the case of the adherent cells, cell membrane permeability is found to be enhanced by the shorter distance between the solution surface and the adherent cells as well as using the cell-solution electrode, which means that the short-lived reactive oxygen species generated at the solution surface are essential for the improvement of cell membrane permeability.

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Section: B Experimental Resultsmentioning

confidence: 99%

Improvement of cell membrane permeability using a cell-solution electrode for generating atmospheric-pressure plasma

et al. 2015

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“…Our current conclusion is that there are target genes, such as p15 / p16 , in oxidative stress‐induced carcinogenesis as described above . Then, the next question would be whether there are any fragile sites in the genome against oxidative stress . There are many types of DNA damage, including single and double strand breaks, base modifications, abasic sites and cross‐links .…”

Section: Introductionmentioning

confidence: 93%

The origin and future of oxidative stress pathology: From the recognition of carcinogenesis as an iron addiction with ferroptosis‐resistance to non‐thermal plasma therapy

Toyokuni

2016

Pathology International

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Helmut Sies established the concept of oxidative stress in 1985. However, it took some time to introduce this concept into pathology, where investigators count on formalin-fixed paraffin-embedded tissue sections. I sought out antigens for this purpose based on an oxidative stress-induced rat renal carcinogenesis model, which revealed that 8-hydroxy-2′-deoxyguanosine and 4-hydroxy-2-nonenal-modified proteins are ideal. These two monoclonal antibodies successfully revealed the involvement of oxidative stress in numerous human diseases, including carcinogenesis and atherosclerosis. Shigeru Okada established the aforementioned ferric nitrilotriacetate (Fe-NTA)-induced rat renal carcinogenesis model, which thus far has answered many questions regarding the presence of target genes in oxidative stress-induced carcinogenesis and the sites that are susceptible to oxidative stress in the genome. Particularly, the similarity of genomic alterations between Fe-NTA-induced renal cancer and human cancers suggests that excess iron plays a role also in human carcinogenesis. Furthermore, excess iron is a major pathology in asbestosinduced mesothelioma, including chrysotile. Despite an analogy to asbestos, multi-wall carbon nanotubes were distinct in that diameter is another responsible factor for mesothelial carcinogenesis. Recently, non-thermal plasma emerged as a candidate for medical intervention for wounds and cancers via manipulating oxidative stress. Counteracting excess iron is a promising preventive strategy for major diseases.

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“…Moreover, iron reduction could make lower risk of hepatic likely other cancers . Akatsuka et al . demonstrate that oxidative stress caused extensive genomic alterations in the cancer genome at the chromosomal level in Fe‐NTA‐induced rat renal cell carcinomas.…”

Section: Discussionmentioning

confidence: 99%

Downregulation of TBXAS1 in an iron‐induced malignant mesothelioma model

Minami

Takigawa²,

Kato

et al. 2015

Cancer Science

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Malignant mesothelioma is an aggressive and therapy-resistant neoplasm arising from mesothelial cells. Evidence suggests that the major pathology associated with asbestos-induced mesothelioma is local iron overload. In the present study, we induced iron-induced mesothelioma in rats based on previous reports. Ten Wistar rats were given ferric saccharate and nitrilotriacetate i.p. for 5 days a week. Five of the ten rats exhibited widespread mesotheliomas in the peritoneum and tunica vaginalis. The tumor cells showed positive immunostaining for calretinin, wilms tumor-1, podoplanin and the oxidative DNA marker 8-hydroxy-2′-deoxyguanosine. In three of the five rats with mesothelioma, array-based comparative genomic hybridization analysis identified a common chromosomal deletion mapped to the chromosomal 4q31 locus, which encompasses the TBXAS1 gene. Downregulation of the TBXAS1 gene was confirmed using quantitative PCR. TBXAS1 gene expression was also reduced in three of four human malignant pleural mesothelioma cell lines compared with normal bronchial epithelial cells. Immunohistochemistry revealed that TBXAS1 expression was weakly positive and positive in five and three out of eight human malignant mesothelioma samples, respectively. In conclusion, TBXAS1 gene expression was downregulated in rats with iron-induced mesothelioma. The relationship between iron overload and TBXAS1 downregulation should be pursued further.

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What has been Learned from the Studies of Oxidative Stress-induced Carcinogenesis: Proposal of the Concept of Oxygenomics

Cited by 29 publications

References 79 publications

Improvement of cell membrane permeability using a cell-solution electrode for generating atmospheric-pressure plasma

Improvement of cell membrane permeability using a cell-solution electrode for generating atmospheric-pressure plasma

The origin and future of oxidative stress pathology: From the recognition of carcinogenesis as an iron addiction with ferroptosis‐resistance to non‐thermal plasma therapy

Downregulation of TBXAS1 in an iron‐induced malignant mesothelioma model

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