What happens to basophils and tryptase, LXA ₄ and CysLTs during aspirin desensitization?

Reprogramming of arachidonic acid metabolism using α-terpineol to alleviate asthma: insights from metabolomics

“…42 Leukotrienes are major factors in the pathogenesis of asthma and LXA4 is a natural antagonist of leukotrienes in vivo. 43 Studies in asthma have found that the more severe the asthma, the lower the LXA4 level and the higher the CysLT level in peripheral blood, BALF and sputum. 43,44 CysLTs induce the differentiation of Th0 cells into Th2 cells, selectively stimulate the secretion of Th2 cytokines, and enhance the type 2 inflammatory response in the airways.…”

“…43 Studies in asthma have found that the more severe the asthma, the lower the LXA4 level and the higher the CysLT level in peripheral blood, BALF and sputum. 43,44 CysLTs induce the differentiation of Th0 cells into Th2 cells, selectively stimulate the secretion of Th2 cytokines, and enhance the type 2 inflammatory response in the airways. 45,46 LXA4 is an important endogenous lipid that mediates the inflammation in asthma regression.…”