Abstract:The emergence and development of artemisinin resistance threaten global malaria control and elimination goals, thereby prompting research on the mechanisms of malaria parasite resistance. The mutation of Plasmodium falciparum Kelch 13 ( PfK13) protein is associated with artemisinin resistance, but the unique or common mechanism by which it leads to this resistance is unclear. By analyzing the different effects of PfK13 mutation on the P. falciparum transcriptome and proteome at the different stages, we found … Show more
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