What does the brain do when you fake it? an fMRI study of pantomimed and real grasping

Króliczak, Grzegorz; Pratesi, C. C.; Goodman, David; Culham, Jody C.

doi:10.1167/6.6.940

Cited by 15 publications

(22 citation statements)

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“…An apparatus consisting of a flat panel, two arms on the side, and a rotatable box ( Figure 1) was used in both Experiments 1 and 2. The rotatable box was modeled after the 'grasparatus' used in several adult studies (e.g., Culham, 2006;Culham et al, 2003;Króliczak, Cavina-Pratesi, Goodman, & Culham, 2007). Two sides of the box were Velcro panels, and the other two sides each contained a slot, one oriented vertically and one oriented horizontally.…”

Section: Apparatusmentioning

confidence: 99%

Dorsal stream function in the young child: an fMRI investigation of visually guided action

James

Kersey

2017

Developmental Science

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Visually guided action is a ubiquitous component of human behavior, but the neural substrates that support the development of this behavior are unknown. Here we take an initial step in documenting visual-motor system development in the young (4- to 7-year-old) child. Through functional MRI and by using a new technique to measure the mechanisms underlying real-time visually guided action in the MRI environment, we demonstrate that children rely primarily on the IPS and cerebellum for this complex behavior. This pattern is consistent across three different visually guided actions, suggesting generalizability of these neural substrates across such tasks. However, minor differences in neural processing across tasks were also demonstrated. Overall, results are interpreted as demonstrating that the functions of the dorsal stream can be viewed as fairly mature in the young child. These results provide a benchmark for future studies that aim to understand the development of the neural circuitry for visually guided action.

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Section: Apparatusmentioning

confidence: 99%

Dorsal stream function in the young child: an fMRI investigation of visually guided action

James

Kersey

2017

Developmental Science

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“…In humans, both functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS) studies have demonstrated the existence of localized cortical reach-to-grasp areas similar to those described in monkeys Culham et al 2006;Kroliczak et al 2007;Tunik et al 2007; for reviews see Castiello 2005;Castiello and Begliomini 2008;Filimon 2010). Overall, reach-to-grasp fMRI studies converge in considering the anterior part of the human intraparietal sulcus (hAIP), a likely homolog of monkey AIP (Grafton et al 1996;Culham et al 2003;Frey et al 2005;Begliomini et al 2007a;Hinkley et al 2009).…”

Section: Introductionmentioning

confidence: 97%

Probing the reaching–grasping network in humans through multivoxel pattern decoding

et al. 2015

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IntroductionThe quest for a putative human homolog of the reaching–grasping network identified in monkeys has been the focus of many neuropsychological and neuroimaging studies in recent years. These studies have shown that the network underlying reaching‐only and reach‐to‐grasp movements includes the superior parieto‐occipital cortex (SPOC), the anterior part of the human intraparietal sulcus (hAIP), the ventral and the dorsal portion of the premotor cortex, and the primary motor cortex (M1). Recent evidence for a wider frontoparietal network coding for different aspects of reaching‐only and reach‐to‐grasp actions calls for a more fine‐grained assessment of the reaching–grasping network in humans by exploiting pattern decoding methods (multivoxel pattern analysis—MVPA).MethodsHere, we used MPVA on functional magnetic resonance imaging (fMRI) data to assess whether regions of the frontoparietal network discriminate between reaching‐only and reach‐to‐grasp actions, natural and constrained grasping, different grasp types, and object sizes. Participants were required to perform either reaching‐only movements or two reach‐to‐grasp types (precision or whole hand grasp) upon spherical objects of different sizes.ResultsMultivoxel pattern analysis highlighted that, independently from the object size, all the selected regions of both hemispheres contribute in coding for grasp type, with the exception of SPOC and the right hAIP. Consistent with recent neurophysiological findings on monkeys, there was no evidence for a clear‐cut distinction between a dorsomedial and a dorsolateral pathway that would be specialized for reaching‐only and reach‐to‐grasp actions, respectively. Nevertheless, the comparison of decoding accuracy across brain areas highlighted their different contributions to reaching‐only and grasping actions.ConclusionsAltogether, our findings enrich the current knowledge regarding the functional role of key brain areas involved in the cortical control of reaching‐only and reach‐to‐grasp actions in humans, by revealing novel fine‐grained distinctions among action types within a wide frontoparietal network.

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“…Human parietal grasp regions (hPGR, Konen et al ., ) as reported in previous literature (#11–15 in Fig. A; Culham et al ., ; Cavina‐Pratesi et al ., ; Kroliczak et al ., ; Cavina‐Pratesi et al ., ; Monaco et al ., ; Konen et al ., ), which unsurprisingly fell in or close to the finger movement network, were separated from the precuneus region by 30−40 mm in the lateral and anterior direction. Human parietal reach regions (hPRR, #1–10 in Fig.…”

Section: Resultsmentioning

confidence: 99%

Automatic representation of a visual stimulus relative to a background in the right precuneus

Uchimura

Nakano

Morito

et al. 2015

Eur J of Neuroscience

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Our brains represent the position of a visual stimulus egocentrically, in either retinal or craniotopic coordinates. In addition, recent behavioral studies have shown that the stimulus position is automatically represented allocentrically relative to a large frame in the background. Here, we investigated neural correlates of the 'background coordinate' using an fMRI adaptation technique. A red dot was presented at different locations on a screen, in combination with a rectangular frame that was also presented at different locations, while the participants looked at a fixation cross. When the red dot was presented repeatedly at the same location relative to the rectangular frame, the fMRI signals significantly decreased in the right precuneus. No adaptation was observed after repeated presentations relative to a small, but salient, landmark. These results suggest that the background coordinate is implemented in the right precuneus.

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What does the brain do when you fake it? an fMRI study of pantomimed and real grasping

Cited by 15 publications

References 0 publications

Dorsal stream function in the young child: an fMRI investigation of visually guided action

Dorsal stream function in the young child: an fMRI investigation of visually guided action

Probing the reaching–grasping network in humans through multivoxel pattern decoding

Automatic representation of a visual stimulus relative to a background in the right precuneus

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