What Does Post-Exercise Proteinuria Tell Us About Kidneys?

Wołyniec, Wojciech; Ratkowski, Wojciech; Zorena, Katarzyna; Januszczyk, Jacek; Kuźbicka, Karolina; Urbański, Robert; Tkachenko-Rita, Patrycja; Renke, Marcin; Rachoń, Dominik

doi:10.18276/cej.2016.2-11

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…These results differed from data obtained from studies on humans, which showed that transient albuminuria is common after intense exercise, especially at high temperatures, with prevalence ranging from 18% to 100%, depending on the type and intensity of exercise and temperature during exercise [5,7]. Both exertion and heat stress result in a decrease in glomerular filtration and renal blood flow (notwithstanding an increase in mean arterial pressure), which reduces urine output [8,9]. The reduction in effective renal flow to 25% leads to post-exercise albuminuria (PA).…”

Section: Introductioncontrasting

confidence: 75%

Impact of High Temperature on Post-Exercise Albuminuria in Dogs

Pasławska

Szczepankiewicz

Bednarska

et al. 2020

Animals

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The literature suggests that strenuous exercise and exposure to high temperatures may cause physiologic proteinuria, but to our knowledge there have been no studies that have assessed the effect of high temperatures on the occurrence of post-exercise albuminuria in dogs. The goal of the study was to assess the impact of high temperatures on the occurrence of albuminuria. Thirteen healthy adult dogs—eight female (62%) and five male (38%) had to run 5 km at a temperature of 25 °C in grasslands which took about 30–40 min. Dogs underwent clinical examinations: echocardiography, abdominal ultrasound, blood hematology and biochemistry and urinalysis, including the ratio of albumin to creatinine (UAC). Baseline UAC was on the borderline of statistical significance for female dogs, but not for male dogs, before and after exercise. UAC was 0.31 ± 0.56 mg/mmol for female dogs and 0.36 ± 0.60 mg/mmol in male dogs before exercise. Immediately after exercise, UAC was 0.51 ± 0.58 mg/mmol in female dogs and 0.31 ± 0.40 mg/mmol in male dogs. Thus, a period of about 30–40 min of intensive exercise at high temperatures (25 °C) did not lead to increased albuminuria. This suggests that there is no need to limit the movement activity before urine tests in dogs, even at high temperatures, before urinalysis.

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Section: Introductioncontrasting

confidence: 75%

Impact of High Temperature on Post-Exercise Albuminuria in Dogs

Pasławska

Szczepankiewicz

Bednarska

et al. 2020

Animals

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Effects of exercise on urinary biochemical parameters and proteins in a group of well-trained military working dogs

Spinella,

Valentini,

Matarazzo

et al. 2023

Veterinary Quarterly

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Exercise-induced proteinuria has been widely investigated in humans, also in relation to intensity and duration of activity. Instead, there are only limited publications regarding urinary biochemical parameters and urinary proteins before and after physical activity in dogs. This paper aimed to investigate the effects of exercise on urinary biochemistry and proteins in military dogs. Twenty-four dogs were enrolled in this study. All the dogs were clinically sound, and they were examined before and after activity. Pulse rates (PR) and respiratory rate (RR) were monitored. Urine was sampled before and after a training session of search activity. Standard urinalysis was carried out, urine total proteins and creatinine were measured and the urinary protein:creatinine ratio was calculated; finally, the urinary proteins were separated using sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE). Clinical examination before and after activity did not reveal any pathological finding. After activity, the PR was slightly increased, while the RR was notably increased ( p < 0.05). Total proteins, albumin, and their ratio with creatinine were significantly higher after exercise when considering all the dogs included or only the females while, when considering only the males no significant difference was detected. The clinical relevance of this study was related to the possibility of using urine as a non-invasive sample for monitoring health status after training activity and exercise in dogs. An increase in microalbuminuria after search activity, measured using SDS-PAGE could be considered an early biomarker of renal function during training sessions.

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