What Does It Take to Diagnose Behçet Disease?

Pandrea, Ancuta; Rudinskaya, Alla; Klein, Betty R.; Krebs, Thorsten

doi:10.1097/01.rhu.0000255693.75314.fd

Cited by 24 publications

(17 citation statements)

References 12 publications

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“…Behçet's disease (BD), described in 1937 by Hulusi Behçet, characterized by recurrent oral and genital ulcers, uveitis, mucocutaneous, articular, neurological, vascular, urogenital, intestinal and pulmonary manifestations, is a chronic, inflammatory, multisystem vasculitis [1][2][3]. BD is more common in the Mediterranean region along the Silk Road to Japan and its' etiology is not yet fully understood.…”

Section: Introductionmentioning

confidence: 99%

Asymmetric dimethylarginine levels in Behçet's Disease

Öztürk¹,

Vatansev²,

Taner³

et al. 2014

Turk J Bioch

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Objective: Behçet's disease (BD) is a chronic, inflammatory, multisystem vasculitis and the etiology is not yet fully understood. Nitric Oxide (NO) is an important molecule for the vascular system which synthesised by the Nitric Oxide Synthase (NOS) enzyme. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of NOS. Therefore, we aimed to investigate levels of the ADMA and its relation with exacerbations in BD patients. Methods:The subjects enrolled in this study were recruited from 34 patients with BD and 34 healthy controls. Serum levels of ADMA, arginine and citrulline were measured by HPLC with fluorescence detection. The ESR and CRP levels analyzed by routinely used methods. Results: In contrast to information in the literature, ADMA levels were found to be decreased in BD patients when compared to control. Inversely, Arginine and Citrulline levels were significantly increased in BD patients. Increased Arginine/ADMA ratios were found in the patient group. There was an inverse relation between ADMA and CRP levels. Arginine values were also correlated CRP and Citrulline levels. Conclusion: One of the reasons of high number of BD attacks in young age may be low levels of ADMA. Our study suggests that the reduced levels of ADMA in patients group may impose a possible preventive role to ADMA through decrease of NO-mediated inflammation and exacerbations of BD with aging. and myocardial infarction; (c) diabetes mellitus, renal and hepatic diseases, active infectious diseases; (d) other known chronic inflammatory diseases. The body mass index (BMI) and blood pressure were recorded. It was also noted that whether the subjects smoke or not. Each subject was evaluated in active and inactive disease periods. At the time of examination, the presence of two or more of the following Behçet's clinical features was considered as active disease: Oral ulceration, genital ulceration, skin lesions, ocular lesions, active major vessel disease, and active major organ involvement including active gastrointestinal or neurological lesions. Subjects with one lesion or lesion-free period were regarded in inactive disease period.The protocol was approved by the Ethics Committee of the Selcuklu Medical Faculty (24.06.2010Faculty (24.06. -2010) and all subjects volunteered for the trial and written consent was obtained according to the Declaration of Helsinki.Blood samples were centrifuged with 2000 x g for 10 min at +4°C, followed by serum removal for assays. All serum samples were stored at -80°C until analysis.Measurements of ADMA, arginine and citrulline levels were accomplished by high performance liquid chromatography (HPLC), using the method described by Taner et al [17]. In brief, 20 mg 5-sulfosalisilic acid was added to 1 ml serum, and the mixture was left in an ice bath for 10 min. The precipitated protein was removed by centrifugation at 2,000×g for 10 min. Ten µl of the supernatant was filtered using a 0.45-μm pore size filter, which was then mixed with 100 μl derivatization reagent [prepared by dissolving ...

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Section: Introductionmentioning

confidence: 99%

Asymmetric dimethylarginine levels in Behçet's Disease

Öztürk¹,

Vatansev²,

Taner³

et al. 2014

Turk J Bioch

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“…Because the diagnosis relies on the combination of clinical manifestations without diagnostic biomarkers, it often takes several years to establish a definitive diagnosis of BD after the appearance of the initial manifestations. 23 BD is prevalent in countries lying along the ancient Silk Road, a route of travel and commerce from the eastern Mediterranean to East Asia. Epidemiologic studies have shown that Turkey has the highest prevalence with 20Y420 cases per 100,000, 9,17 followed by Japan, Korea, China, Iran, and Saudi Arabia, where the frequency has been reported to range from 13.5 to 22 cases per 100,000.…”

Section: Introductionmentioning

confidence: 99%

Behçet Disease

et al. 2011

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Clinical phenotypes of Behçet disease (BD) vary among ethnic groups. We chronologically analyzed the clinical manifestations of BD in 412 patients meeting the Japanese criteria for BD seen at 2 Yokohama City University hospitals from July 1991 to December 2007. We examined the onset of individual symptoms in each patient. A single initial symptom appeared earlier than any other manifestation in 78% of the patients. Time from the initial symptom to diagnosis was 8.6 ± 10.1 years. Oral ulcer, the most common initial manifestation, preceded the diagnosis by 7.5 ± 10.2 years. Genital ulcer and eye and skin involvement appeared 1 or 2 years before diagnosis, whereas gastrointestinal, central nervous system, or vascular involvement developed later. The frequency of eye involvement was significantly higher in patients with neurologic lesions, but significantly lower in those with gastrointestinal or vascular involvement. However, no particular combination of major symptoms predicted the development of organ involvement. There has been a recent decrease in the rate of "complete" BD (patients having all 4 of the major symptoms of oral ulcers, genital ulcers, and eye and skin lesions), whereas the frequencies of arthritis, gastrointestinal, and vascular involvement have been increasing. Further assessment may allow the detection of early predictors of the more aggressive disease, which requires more intensive treatment.

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“…ehçet disease (BD) is a multisystem condition characterized by mainly mucocutaneous findings including recurrent oral and genital ulcers, ocular, articular, neurologic, urogenital, vascular, intestinal, and pulmonary manifestations (1). Classified as a systemic vasculitis, it can involve both the arteries and veins of any size in almost any organ.…”

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confidence: 99%