What do we know of post‐thrombotic syndrome? Current status of post‐thrombotic syndrome in adults

Reich‐Schupke, Stefanie; Altmeyer, Peter; Stücker, Markus

doi:10.1111/j.1610-0387.2009.07211.x

Cited by 8 publications

(7 citation statements)

References 48 publications

(55 reference statements)

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“…This syndrome is more commonly observed in male gender, obese, and elderly patients [15]. The influence of several risk factors on the incidence of PTS is till controversial [16]. The determinants of postthrombotic manifestations include the rate of recanalization, 2 ISRN Vascular Medicine the global extend of reflux, the anatomic distribution of reflux and obstruction, the recurrent thrombotic events, and thrombophilia.…”

Section: Discussionmentioning

confidence: 99%

Pathophysiology of Post-Thrombotic Syndrome: The Effect of Recurrent Venous Thrombosis and Inherited Thrombophilia

Kreidy

2011

ISRN Vascular Medicine

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Post-thrombotic syndrome is an important chronic complication of deep vein thrombosis. This syndrome can be debilitating to patients and has a major economic impact on health care services. The pathophysiology of post-thrombotic syndrome is currently incompletely understood. Because therapeutic options for post-thrombotic syndrome are extremely limited and results are often disappointing, recognizing of the pathophysiology and risk factors of this syndrome is essential to prevent the disabling consequences of this disease. The present paper focuses on risk determinants of post-thrombotic syndrome after deep vein thrombosis. The contribution of recurrent venous thrombosis and inherited thrombophilia to the pathogenesis of this syndrome is reviewed and discussed in details.

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Section: Discussionmentioning

confidence: 99%

Pathophysiology of Post-Thrombotic Syndrome: The Effect of Recurrent Venous Thrombosis and Inherited Thrombophilia

Kreidy

2011

ISRN Vascular Medicine

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“…These processes explain the features of chronic venous insufficiency characteristic of PTS. 25 The above description applies largely to lower limb PTS pathophysiology. Upper limbs are relatively protected from PTS due to abundant collaterals, lack of reflux and a shorter hydrostatic column.…”

Section: Introductionmentioning

confidence: 99%

Post thrombotic syndrome following deep vein thrombosis in paediatric patients

et al. 2017

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Background Although well characterised in adults, less is known about post-thrombotic syndrome in children. In this review, current knowledge regarding paediatric post-thrombotic syndrome is summarised, with particular emphasis on pathophysiology, aetiology, diagnosis and management. Methods A Medline literature review was performed using search terms 'post thrombotic syndrome', 'post phlebitic syndrome', paediatric and children. Relevant articles were identified and included for summation analysis. Results The incident of paediatric venous thromboembolism is rising. Deep vein thrombosis can cause venous hypertension through a combination of venous reflux, venous obstruction and impairment of the calf muscle pump, leading to development of post-thrombotic syndrome. In children, this is more likely to occur if deep vein thrombosis diagnosis and treatment are delayed, if a higher number of vessels are involved, and if factors such as D-dimer are elevated at diagnosis and throughout treatment. Post-thrombotic syndrome occurs in about 26% of paediatric deep vein thrombosis, though the results of individual studies vary widely. A number of tools exist to diagnose paediatric post-thrombotic syndrome, including the modified Villalta scale and Manco-Johnson instrument. Once post-thrombotic syndrome develops, the mainstay of treatment remains supportive, with little evidence of benefit from pharmacological measures. Conclusion Surgical or interventional treatment is not advised except in exceptional cirumstances, due to variable prognosis of PTS in paediatric populations with rising incidence of paediatric venous thromboembolism, it follows that the prevalence of post-thrombotic syndrome in children may also increase. Evidence-based venous thromboembolism prevention strategies need to be implemented for prevention of deep vein thrombosis, but when it does occur, deep vein thrombosis requires prompt and effective treatment to prevent post-thrombotic syndrome. Optimum treatment strategies for post-thrombotic syndrome require further investigation.

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“…PTS is characterized by obstruction of the deep venous system, which can be associated with venous valve incompetence, venous hypertension, and pathological reflux. Given the complexity of the pathogenesis and, in particular, the treatment of PTS, we would like to refer the interested reader to the following review articles .…”

Section: Complicationsmentioning

confidence: 99%

Chronic venous insufficiency – a review of pathophysiology, diagnosis, and treatment

Santler

Goerge

2017

J Deutsche Derma Gesell

101

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SummaryChronic venous disease is a common disorder associated with a variety of symptoms in later disease stages but also with complications such as venous leg ulcer. This, in turn, has substantial socioeconomic effects and significantly impacts patients' quality of life. While there are a number of diagnostic procedures available, color-flow duplex ultrasound has become the gold standard. As regards therapeutic options, major advances have been made in recent decades. Today, there are alternatives to saphenofemoral ligation and stripping of the great saphenous vein, including endovenous thermal ablation techniques. However, treatment selection continues to depend on many factors such as individual anatomical circumstances and disease stage. The following article provides an overview of the anatomy and pathophysiology as well as current diagnostic and therapeutic standards.

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What do we know of post‐thrombotic syndrome? Current status of post‐thrombotic syndrome in adults

Cited by 8 publications

References 48 publications

Pathophysiology of Post-Thrombotic Syndrome: The Effect of Recurrent Venous Thrombosis and Inherited Thrombophilia

Pathophysiology of Post-Thrombotic Syndrome: The Effect of Recurrent Venous Thrombosis and Inherited Thrombophilia

Post thrombotic syndrome following deep vein thrombosis in paediatric patients

Chronic venous insufficiency – a review of pathophysiology, diagnosis, and treatment

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