What do we know about quality of life in dementia? A review of the emerging evidence on the predictive and explanatory value of disease specific measures of health related quality of life in people with dementia

Banerjee, Sube; Samsi, Kritika; Petrie, Charles D.; Alvir, José; Treglia, Michael; Schwam, Ellias M.; Valle, Megan del

doi:10.1002/gps.2090

Cited by 263 publications

(387 citation statements)

References 56 publications

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“…Quantitative studies on self-reported, health-related quality of life (HRQL) (see Banerjee et al 2009, for a review) have revealed little or no statistically significant relationship between severity of cognitive impairment and HRQL. Likewise, longitudinal studies have demonstrated that patterns of self-reported HRQL did not match downward curves of cognitive outcomes (Missotten et al 2007;Selwood et al 2005).…”

Section: Perceptions Of Consequencesmentioning

confidence: 99%

Dementia worry: a psychological examination of an unexplored phenomenon

et al. 2012

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According to recent surveys, dementia worry (DW) is a widespread phenomenon in mid-life and old age, at least in Western populations. DW has been shown to be only loosely related to sociodemographic factors. Unfortunately, the concept of DW has found only very little conceptual and empirical attention in previous research. In this conceptual review, we take (mostly) a psychological approach to DW. First, we define DW as an emotional response to the perceived threat of developing dementia. We then conceptualise DW as a hybrid, combining elements of ageing anxiety and health anxiety. On the population level, we argue that the high prevalence of DW may be reflective of the increasing awareness of dementia in times of increasing ''dementia encounters', widespread misperceptions of risks and consequences of dementia and a perceived lack of coping resources. Finally, we propose that DW may affect a range of important behaviours, such as how people interpret evidence of their own or others' age-related cognitive changes, how they interact with people with dementia, how they anticipate and plan for their future, how they engage in screening and prevention behaviours and how they exploit healthcare resources. We conclude with suggestions for future research, including a further in-depth investigation of psychological and micro-/ macrosocial factors associated with DW.

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Section: Perceptions Of Consequencesmentioning

confidence: 99%

Dementia worry: a psychological examination of an unexplored phenomenon

et al. 2012

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“…Selv om flere proxybaserte studier finner en signifikant sammenheng mellom adferd og livskvalitet, ser man i studier hvor personen med demens selv har gitt opplysninger om sin livskvalitet, at denne sammenhengen minsker eller forsvinner (29,39,40). Dette kan ha sammenheng med redusert innsikt i egen situasjon, men kan også vaere et uttrykk for at adferd som pleiepersonell opplever som problematisk, ikke er det for personen med demens (8,41).…”

Section: Metodeunclassified

“…I våre analyser er kjønn ikke signifikant korrelert med livskvalitet. Dette er i samsvar med andre studier (5,8,17). Sammenhengen mellom alder og livskvalitet er uklar i vår studie.…”

Section: Metodeunclassified

“…Ulike faktorer påvirker livskvalitet hos personer med demens (8)(9)(10)(11)(12), blant annet får de utover i sykdommen problemer med å uttrykke tanker og følelser, og hukommelsen reduseres (13). Dette reduserer personens egen mulighet til selv å beskrive hvordan livet oppleves.…”

Section: Introduksjonunclassified

“…I de ulike studiene ser man en tendens til at det oftere er sammenheng mellom funksjonsnivå og livskvalitet hos personer med demens når en annen enn pasienten gir informasjon. Denne sammenhengen ser man ikke i like stor grad dersom informasjon om livskvalitet og funksjonssvikt er selvrapportert (8,26,29). Problemstillingen om sammenhengen mellom livskvalitet hos personer med demens og depressive symptomer, funksjonssvikt og grad av demens er fortsatt aktuell.…”

Section: Introduksjonunclassified

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Livskvalitet, depressive symptomer og funksjonssvikt hos personer med demens

Mjørud¹,

Engedal²,

Barca³

et al. 2011

Sykepleien

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English summary sammEndrag Quality of life, depressive symptoms and impairment in people with dementiaBackground: It is uncertain whether the association between quality of life, the symptoms of depression and impairment of daily living activities is as strong in people with dementia, as in those without dementia.Objective: To investigate the association between quality of life, the symptoms of depression, impairment of daily living activities and dementia.Methods: Information about 223 nursing home patients with dementia was collected through interviews with the primary caregivers. Quality of life was examined using the Quality of Life in Late Stage Dementia (QUA-LID) scale; symptoms of depression were examined using the Cornell scale; impairment of daily living activities was examined using Lawton's Physical Self-Maintenance Scale (PSMS); and the degree of dementia was examined using the Clinical Dementia Rating scale. Results: Correlation analysisshowed that reduce quality of life was significantly associated with depressive symptoms, functional impairment and dementia. A stepwise linear regression analysis showed that four of Cornell's five sub scales: the mood, behavioural, retardation and cyclic subscales were significantly associated with QUALID. The physical sub scale was not associated with quality of life in the regression analysis because retardation and physical sub scales correlated highly. Impairment of activities of daily living and degree of dementia are significantly associated to reduced quality of life. Conclusion:Quality of life in people with dementia is associated with symptoms of depression, especially the core symptoms of depression and level of impairment of activities of daily living.Key words: quality of life, symptoms of depression, impairment of activities in daily living, dementia.Bakgrunn: Det er usikkert om sammenhengen mellom livskvalitet, depressive symptomer og funksjonssvikt er like sterk hos personer med demens som hos dem uten demens.Hensikt: Å undersøke sammenhengen mellom livskvalitet, depressive symptomer, funksjonssvikt og grad av demens. Metode:Opplysninger om 223 pasienter med demens i sykehjem ble innhentet gjennom intervju av pasientenes primaerpleiere. Livskvalitet ble kartlagt med Quality of life in late stage dementia scale (QUALID), symptomer på depresjon med Cornell skala, funksjonsevne med Lawtons ADL skala og grad av demens med Klinisk demensvurdering.Resultater: Korrelasjonsanalyser viste at livskvalitet var signifikant assosiert til depressive symptomer, grad av demens og tap av funksjonsevne. Spearman's korrelasjon varierte mellom 0,37 og 0,53. En trinnvis lineaer regresjonsanalyse viste at fire av fem subskalaer i Cornell skalaen, affekt-, adferds-, retardasjon -og syklisk subskala var signifikant assosiert med QUALID-skåren. Den fysiske sub skalaen var det ikke fordi sub skalaene retardasjon og fysisk korrelerte sterkt. Tap av funksjonsevne og grad av demens var også signifikant relatert til redusert livskvalitet.Konklusjon: Livskvalitet hos personer med ...

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Cautionary Tales in the Interpretation of Clinical Studies Involving Older Persons

Scott

Guyatt²

2010

Arch Intern Med

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The care of patients 65 years or older presents a challenge for evidence-based medicine. Such patients are underrepresented in clinical trials, are more vulnerable to treatment-induced harm, and often are unable to fully participate in treatment decisions. We outline several cautionary themes in the interpretation of clinical studies of therapeutic interventions involving older persons as they apply to processes of everyday clinical decision making. In particular, we focus on issues of study design and quality of evidence, choice of outcome measures, missing outcome data, assessment of potential harm, quantifying treatment effects in individual patients (and adjusting these for effect modifiers and reduced life expectancy), eliciting patient values and preferences, prioritizing therapeutic goals and selection of treatments, and assisting patients in adhering to agreed therapeutic regimens.

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What do we know about quality of life in dementia? A review of the emerging evidence on the predictive and explanatory value of disease specific measures of health related quality of life in people with dementia

Cited by 263 publications

References 56 publications

Dementia worry: a psychological examination of an unexplored phenomenon

Dementia worry: a psychological examination of an unexplored phenomenon

Livskvalitet, depressive symptomer og funksjonssvikt hos personer med demens

Cautionary Tales in the Interpretation of Clinical Studies Involving Older Persons

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