What do we know about the cardiac benefits of exercise?

Wei, Xin; Liu, Xiaojun; Rosenzweig, Anthony

doi:10.1016/j.tcm.2014.12.014

Cited by 48 publications

(42 citation statements)

References 60 publications

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“…Multiple lines of evidence suggest exercise has benefits for primary and secondary prevention of cardiovascular disease (1). Exercise induces important systemic changes affecting the cardiovascular system through alterations in metabolism, peripheral vessels, and skeletal muscle.…”

Section: Introductionmentioning

confidence: 99%

CITED4 induces physiologic hypertrophy and promotes functional recovery after ischemic injury

Bezzerides¹,

Platt²,

Lerchenmüller³

et al. 2016

JCI Insight

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The mechanisms by which exercise mediates its multiple cardiac benefits are only partly understood. Prior comprehensive analyses of the cardiac transcriptional components and microRNAs dynamically regulated by exercise suggest that the CBP/p300-interacting protein CITED4 is a downstream effector in both networks. While CITED4 has documented functional consequences in neonatal cardiomyocytes in vitro, nothing is known about its effects in the adult heart. To investigate the impact of cardiac CITED4 expression in adult animals, we generated transgenic mice with regulated, cardiomyocyte-specific CITED4 expression. Cardiac CITED4 expression in adult mice was sufficient to induce an increase in heart weight and cardiomyocyte size with normal systolic function, similar to the effects of endurance exercise training. After ischemia-reperfusion, CITED4 expression did not change initial infarct size but mediated substantial functional recovery while reducing ventricular dilation and fibrosis. Forced cardiac expression of CITED4 also induced robust activation of the mTORC1 pathway after ischemic injury. Moreover, pharmacological inhibition of mTORC1 abrogated CITED4’s effects in vitro and in vivo. Together, these data establish CITED4 as a regulator of mTOR signaling that is sufficient to induce physiologic hypertrophy at baseline and mitigate adverse ventricular remodeling after ischemic injury.

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Section: Introductionmentioning

confidence: 99%

CITED4 induces physiologic hypertrophy and promotes functional recovery after ischemic injury

Bezzerides¹,

Platt²,

Lerchenmüller³

et al. 2016

JCI Insight

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“…However, it is worth acknowledging that the large majority of evidence supporting this perspective is observational in nature and thus cannot establish a causal relationship (Wei et al 2014). Such observational studies are inherently limited by multiple factors, including selection and recall biases, unrecognized confounding, and inaccurate self-reporting of activity.…”

Section: Clinical Benefits Of Exercisementioning

confidence: 99%

“…How likely is it that exercise-related pathways will also mitigate the response to pathological stress and/or established cardiovascular disease? Interestingly, the large majority of pathways identified thus far as functionally important in the cardiac response to exercise also protect the heart against pathological stress (Wei et al 2014;Roh et al 2016). As discussed below, examples include phosphoinositide-3-kinase (PI3K) (McMullen et al 2003;Weeks et al 2012), Akt1 (Matsui et al 1999(Matsui et al , 2001DeBosch et al 2006), endothelial nitric oxide synthase (eNOS) (Calvert et al 2011), peroxisome proliferator-activated receptor g coactivator 1a (PGC-1a) (Arany et al 2006(Arany et al , 2008, C/EBPb (Bostrom et al 2010), and CITED4 (Bezzerides et al 2016).…”

Section: Rationale For Studying Exercisementioning

confidence: 99%

The Role of MicroRNAs in the Cardiac Response to Exercise

Liu

Platt

Rosenzweig

2017

Cold Spring Harb Perspect Med

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“…L'activité physique amène une diminution d'environ 30 %d el am ortalité cardio-vasculaire, à la fois en prévention primaire et secondaire [77]. Elle permet une augmentation des affects positifs et une diminution nette de l'anxiété et de la dépression.…”

Section: Quelle Est L'efficacité De Ces Méthodes Non Médicamenteuses ?unclassified

La psychocardiologie : une nouvelle spécialité

Houppe¹

2017

Hegel

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RésuméLe corps et l'esprit sont intimement liés. Les relations entre coeur et cerveau sont très fortes. La naissance de la psychocardiologie apparaîtc omme une évidence. Le stress psychosocial est à la fois un facteur de risque indépendant et un facteur pronostic d'événements cardiovasculaires. Il comprend des aspects psychologiques, des composantes sociologiques et socio-économiques. Il apparaîta ussi que la maladie cardiaque est elle-même un événement déclenchant de stress psychosocial.Les recommandations européennes sont de grade 1A pour l'évaluation du risque psychosocial et de grade 1B pour la prise en charge.Les connaissances actuelles sur le développement cérébral permettent de mieux comprendre la relation qui existe entre le stress psychosocial et le risque cardiovasculaire. Le risque psychosocial augmente les facteurs de risque classiques et entraîne par ailleurs une dysfonction endothéliale, une réponse inflammatoire et une activation de la coagulation.Les anxiolytiques et les antidépresseurs ne sont pas très efficaces dans la prise en charge du stress psychosocial, en revanche l'activité physique et les psychothérapies sont plus indiquées en particulier les thérapies cognitivo-comportementales, les thérapies de la pleine conscience et la thérapie EMDR.Depuis qu'il a été proposéàla find es années 70, le modèle biopsychosocial ne cesse d'accumuler des preuves de sa pertinence. Les recherches en médecine psychosomatique ,e nc ardiologie et en psychologie de la santé ont permis de faire en sorte que la psychocardiologie devienne une nouvelle spécialité fondées ur l'evidence based medicine. Il reste maintenant à faire en sorte que ces connaissances puissent être transmises aux praticiens et qu'ils puissent inclure cet aspect dans leur pratique quotidienne. Mots-clésCardiologie ;P sychocardiologie ;S tress psychosocial ;P sychothérapie ;P r é vention cardiaque Abstract Body and mind are closely linked. The relationships between the brain and the heart are very strong.T he emergence of pyschocardiology appears to be as imple truism. On the one hand

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What do we know about the cardiac benefits of exercise?

Cited by 48 publications

References 60 publications

CITED4 induces physiologic hypertrophy and promotes functional recovery after ischemic injury

CITED4 induces physiologic hypertrophy and promotes functional recovery after ischemic injury

The Role of MicroRNAs in the Cardiac Response to Exercise

La psychocardiologie : une nouvelle spécialité

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