What Do We Know about the Natural Outcomes of Preterm Labour? A Systematic Review and Meta‐Analysis of Women without Tocolysis in Preterm Labour

Hackney, David; Olson-Chen, Courtney; Thornburg, Loralei L.

doi:10.1111/ppe.12070

Cited by 15 publications

(11 citation statements)

References 24 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This rate was similar to the rate in studies of preterm labor with cervical dilatation. 20 , 21 The rates of term delivery, birth weight, and neonatal complications between the nifedipine and the placebo groups were not significantly different. These rates were similar to the rates in studies of preterm labor with cervical dilatation.…”

Section: Discussionmentioning

confidence: 82%

Effectiveness of nifedipine in threatened preterm labor: a randomized trial

Songthamwat¹,

Nan²,

Songthamwat³

2018

IJWH

View full text Add to dashboard Cite

ObjectiveThreatened preterm labor is a condition in which regular uterine contractions occur at least 1 time in 10 minutes and persist for more than 30 minutes before completion of 37 weeks of gestation without dilatation of the cervix. In preterm labor with cervical dilatation, the efficacy of tocolytics was proven for prolonging pregnancy. However, in threatened preterm labor, the efficacy of tocolytics has not yet been well studied. This study aimed to evaluate the effectiveness of nifedipine versus a placebo for inhibiting uterine contraction in threatened preterm labor.Materials and methodsA randomized, double-blinded, placebo-controlled study with 206 threatened preterm labor patients was undertaken. The participants were randomly allocated into either nifedipine or placebo groups. The proportion of patients with successful treatment, gestational age at delivery, and neonatal outcome were compared between the 2 groups.ResultsAfter 90 minutes of treatment, 88.3% of the nifedipine group and 69.9% of the placebo group had no uterine contraction (P<0.001). Nifedipine led to successful treatment outcomes in 77.6% of the total participants compared with 49.5% in the placebo group (P<0.001). The remainder of the participants from both groups needed a second-line tocolytic drug. Of these, 9.7% in the nifedipine group delivered within 48 hours compared with 12.6% in the placebo group (P>0.05). Mean gestation age at delivery and neonatal complications for both groups were not significantly different.ConclusionNifedipine had a higher success rate for inhibiting threatened preterm contractions.

show abstract

Section: Discussionmentioning

confidence: 82%

Effectiveness of nifedipine in threatened preterm labor: a randomized trial

Songthamwat¹,

Nan²,

Songthamwat³

2018

IJWH

View full text Add to dashboard Cite

show abstract

“…This study relied on data from hospital discharge records and birth certificates for analysis. Data were not available to examine other important risk factors for preterm birth (eg, maternal body mass index, 7 income, 25 employment, 26 tocolysis, 27 assisted reproduction, 28 and cervical surgery 29 ). The existing data could not identify elective delivery at 37 and 38 weeks of gestation, which are important points for investigation as this area of work progresses.…”

Section: Discussionmentioning

confidence: 99%

Recurrence of Preterm Birth and Early Term Birth

Yang

Baer

Berghella

et al. 2016

Obstetrics &Amp; Gynecology

View full text Add to dashboard Cite

OBJECTIVE To examine recurrent preterm birth and early term birth in women’s initial and immediately subsequent pregnancies. METHODS This retrospective cohort study included 163,889 women who delivered their first and second liveborn singleton neonates between 20 and 44 weeks of gestation in California from 2005 through 2011. Data from hospital discharge records and birth certificates were used for analyses. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression models adjusted for risk factors. RESULTS Shorter gestational duration in the first pregnancy increased the risk of subsequent preterm birth (both early, before 32 weeks of gestation, and later, from 32 to 36 weeks of gestation) as well as early term birth (37–38 weeks of gestation). Compared with women with a prior term birth, women with a prior early preterm birth (before 32 weeks of gestation) were at the highest risk for a subsequent early preterm birth (58/935 [6.2%] compared with 367/118,505 [0.3%], adjusted OR 23.3, 95% CI 17.2–31.7). Women with a prior early term birth had more than a twofold increased risk for subsequent preterm birth (before 32 weeks of gestation: 171/36,017 [0.5%], adjusted OR 2.0, 95% CI 1.6–2.3; from 32 to 36 weeks of gestation: 2,086/36,017 [6.8%], adjusted OR 3.0, 95% CI 2.9–3.2) or early term birth (13,582/36,017 [37.7%], adjusted OR 2.2, 95% CI 2.2–2.3). CONCLUSION Both preterm birth and early term birth are associated with these outcomes in a subsequent pregnancy. Increased clinical attention and research efforts may benefit from a focus on women with a prior early term birth as well as those with prior preterm birth.

show abstract

“…Of these, two systematic reviews reported [ 16 , 20 ] that applicable data were found, but neither of the systematic reviews used the data. Furthermore, 8 of the reviews did not clearly indicate whether or not data were found [ 17 , 19 , 21 – 26 ] and it was not possible to determine whether or not the data were used in 1 of the reviews [ 22 ]. In each of these cases, the corresponding cells are marked “yellow”.…”

Section: Resultsmentioning

confidence: 99%

Clinical trials registries are underused in the pregnancy and childbirth literature: a systematic review of the top 20 journals

et al. 2016

View full text Add to dashboard Cite

BackgroundSystematic reviews and meta-analyses that do not include unpublished data in their analyses may be prone to publication bias, which in some cases has been shown to have deleterious consequences on determining the efficacy of interventions.MethodsWe retrieved systematic reviews and meta-analyses published in the past 8 years (January 1, 2007–December 31, 2015) from the top 20 journals in the Pregnancy and Childbirth literature, as rated by Google Scholar’s h5-index. A meta-epidemiologic analysis was performed to determine the frequency with which authors searched clinical trials registries for unpublished data.ResultsA PubMed search retrieved 372 citations, 297 of which were deemed to be either a systematic review or a meta-analysis and were included for analysis. Twelve (4 %) of these searched at least one WHO-approved clinical trials registry or clinicaltrials.gov.ConclusionSystematic reviews and meta-analyses published in pregnancy and childbirth journals do not routinely report searches of clinical trials registries. Including these registries in systematic reviews may be a promising avenue to limit publication bias if registry searches locate unpublished trial data that could be used in the systematic review.

show abstract

What Do We Know about the Natural Outcomes of Preterm Labour? A Systematic Review and Meta‐Analysis of Women without Tocolysis in Preterm Labour

Abstract: Most women without tocolysis do not deliver within 7 days, although the range is very wide. The majority of this variation is unrelated to reported differences in study design or reported population characteristics.

Cited by 15 publications

References 24 publications

Effectiveness of nifedipine in threatened preterm labor: a randomized trial

Effectiveness of nifedipine in threatened preterm labor: a randomized trial

Recurrence of Preterm Birth and Early Term Birth

Clinical trials registries are underused in the pregnancy and childbirth literature: a systematic review of the top 20 journals

Contact Info

Product

Resources

About