What common biomarkers characterize a triple-negative profile in breast cancer?

Kallel, Imen; Rebaı̈, Mohamed; Khabir, Abdelmajid; Rebaï, Ahmed

doi:10.1016/j.patbio.2015.07.005

Cited by 9 publications

(9 citation statements)

References 94 publications

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“…Several predictive biomarkers in TNBC, including the epidermal growth factor receptor (EGFR), androgen receptor and the adhesion molecules CD24 and CD44, have been investigated in recent years (28–31). To the best of the authors' knowledge, the prognostic value of the expression levels of CRT and EVI-1 in TNBC is unknown.…”

Section: Introductionmentioning

confidence: 99%

Ecotropic virus integration‑1 and calreticulin as novel prognostic markers in triple‑negative breast cancer: A retrospective cohort study

et al. 2019

Oncol Lett

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Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer, for which no specific targete d therapy is currently available. The present study aimed to examine the associations of ecotropic virus integration site 1 (EVI-1) and calreticulin (CRT) with other clinicopathological variables and the prognosis of patients with TNBC. The present retrospective cohort study reviewed the medical records of patients with TNBC treated in the Affiliated Hospitals of Jinzhou Medical University between January 2010 and June 2015. The protein expression levels of EVI-1 and CRT in tumor samples obtained from the patients were examined by immunohistochemical analysis. Univariate and multivariate regression analyses were used to identify associations between clinical characteristics and disease-free survival (DFS) or overall survival (OS). Kaplan-Meier analysis was performed to observe the survival condition (DFS/OS) according to EVI-1 and CRT expression. A total of 88 TNBC patients were included in the present study. Tumor tissues in 52 (59.1%) patients were EVI-1 positive, and tumor tissues in 64 (72.7%) patients were CRT-positive, and these rates were significantly higher compared with those in the corresponding paracancerous tissues (P<0.05). Multivariate analysis revealed that EVI-1 and CRT expression levels were independent variables associated with OS and DFS, and high expression of both CRT and EVI-1 was significantly associated with decreased OS and DFS compared with the other subgroups (low EVI-1/low CRT expression, low EVI-1/high CRT expression and high EVI-1/low CRT expression) of patients with TNBC. EVI-1 and CRT expression in TNBC was significantly correlated with poor outcome. Evaluation of the EVI-1 and CRT status may provide insight into prognosis prediction for patients with TNBC.

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Section: Introductionmentioning

confidence: 99%

Ecotropic virus integration‑1 and calreticulin as novel prognostic markers in triple‑negative breast cancer: A retrospective cohort study

et al. 2019

Oncol Lett

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“…An earlier case study on Korean women ( n = 1026) indicated that the mean age of breast cancer diagnosis was 46.8 years with 14.4 and 26.3 as the age of menarche and first parturition ( Kang et al, 2014 ). However, other studies indicated that 2–20% of women diagnosed with breast cancer were under the age of 35 years with tumors that present aggressive biological behavior resulting in mortality and metastasis ( Kallel et al, 2015 ). Moreover, women’s reproductive life, precocious menarche, nulliparity, age of first gestation over 30 years, oral contraceptives, late menopause, and hormone replacement therapy are also well established in relation to breast cancer development ( Thuler, 2003 ; Pinho and Coutinho, 2007 ; Brasil, 2008 , 2009 ).…”

Section: Resultsmentioning

confidence: 99%

“…The age in association with hormone receptors status, family history, and genetic aspects may have implications on cancer therapies ( Peto and Mack, 2000 ; Pinho and Coutinho, 2007 ; Lizarraga et al, 2013 ). Previous studies have shown that young women with triple negative breast tumors have worst prognosis regarding recurrence and mortality ( Kallel et al, 2015 ; Reviriego et al, 2016 ). Endocrine factors/reproductive history is mainly related to estrogen stimulation whether endogenous or exogenous, pregnancy after 30 years, nulliparity, use of oral contraceptives (estrogen–progesterone), and postmenopausal hormone replacement therapy (estrogen–progesterone) are all associated with breast cancer incidence ( International Agency for Research on Cancer [IARC], 2015 ; World Health Organization [WHO], 2015 ).…”

Section: Resultsmentioning

confidence: 99%

Correlations between Risk Factors for Breast Cancer and Genetic Instability in Cancer Patients—A Clinical Perspective Study

et al. 2018

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Molecular epidemiological studies have identified several risk factors linking to the genes and external factors in the pathogenesis of breast cancer. In this sense, genetic instability caused by DNA damage and DNA repair inefficiencies are important molecular events for the diagnosis and prognosis of therapies. Therefore, the objective of this study was to analyze correlation between sociocultural, occupational, and lifestyle risk factors with levels of genetic instability in non-neoplastic cells of breast cancer patients. Total 150 individuals were included in the study that included 50 breast cancer patients submitted to chemotherapy (QT), 50 breast cancer patients submitted to radiotherapy (RT), and 50 healthy women without any cancer. Cytogenetic biomarkers for apoptosis and DNA damage were evaluated in samples of buccal epithelial and peripheral blood cells through micronuclei and comet assay tests. Elder age patients (61–80 years) had higher levels of apoptosis (catriolysis by karyolysis) and DNA damage at the diagnosis (baseline damage) with increased cell damage during QT and especially during RT. We also reported the increased frequencies of cytogenetic biomarkers in patients who were exposed to ionizing radiation as well as for alcoholism and smoking. QT and RT induced high levels of fragmentation (karyorrhexis) and nuclear dissolution (karyolysis) and DNA damage. Correlations were observed between age and karyorrhexis at diagnosis; smoking and karyolysis during RT; and radiation and karyolysis during QT. These correlations indicate that risk factors may also influence the genetic instability in non-neoplastic cells caused to the patients during cancer therapies.

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“…Up-regulation: Micro-RNAs (miR-10b, miR-341, miR-195) (Bedreag et al, 2015); ER, PR, CA15-3, HER2 (Silva, 2015); EGFR, TNBC, HER1/ErbB1, HER2/new/ErbB2, HER3/ ErbB3, and HER4/ErbB4, TNCs, Bcl-2, adhesion molecule (CD44/CD24), BRCA1/A2, p53, p63, p53siRNA gene, p16INK4a, cytokeratins 5, 14, and 17 (Kallel et al, 2015).…”

Section: Breast Cancermentioning

confidence: 99%

Dictatorial streaming of biomarkers in some diseases

Islam

Riaz

Ferdous

et al. 2016

IJAPSR

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ABSTRACT:The term "biomarker" is used from 1980. Nowadays, diagnosis/prognosis and research in medical science are more concerned with the discovery and utilization of a number of biomarkers. The information in the library of biomarkers is rising day by day as their major concerns relate diseases, pathogenicity or pharmacology in a variety of hosts. Taking into account, we summarize a number of biomarkers in a number of diseases in human. It includes the name and their up-and/or down expressions in those situations. However, no description was plugged with the individual fact.

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What common biomarkers characterize a triple-negative profile in breast cancer?

Cited by 9 publications

References 94 publications

Ecotropic virus integration‑1 and calreticulin as novel prognostic markers in triple‑negative breast cancer: A retrospective cohort study

Ecotropic virus integration‑1 and calreticulin as novel prognostic markers in triple‑negative breast cancer: A retrospective cohort study

Correlations between Risk Factors for Breast Cancer and Genetic Instability in Cancer Patients—A Clinical Perspective Study

Dictatorial streaming of biomarkers in some diseases

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