What causes the spatial heterogeneity of bacterial flora in the intestine of zebrafish larvae?

Yang, Jinyou; Shimogonya, Yuji; Ishikawa, Takuji

doi:10.1016/j.jtbi.2018.03.007

Cited by 4 publications

(4 citation statements)

References 29 publications

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“…Mathematical modeling enables investigation of the distribution and growth of bacteria by clarifying complex phenomena via well-defined numerical experiments. Mathematical models of the gut bacterial flora have been reported ( Ishikawa et al , 2011 ; Cremer et al , 2016 ; Yang et al , 2018 ). In this section, we introduce the computational model of Yang et al (2018) .…”

Section: Gut Floramentioning

confidence: 99%

“…Mathematical models of the gut bacterial flora have been reported ( Ishikawa et al , 2011 ; Cremer et al , 2016 ; Yang et al , 2018 ). In this section, we introduce the computational model of Yang et al (2018) . They attempted to reproduce the findings of Jemielita et al (2014) , in which Aeromonas in the larval zebrafish intestine exhibited a heterogeneous distribution and aggregated in the middle of the intestinal tract.…”

Section: Gut Floramentioning

confidence: 99%

“… Yang et al (2018) expressed the distribution and growth of bacteria in the intestine of a zebrafish larva using four conservation laws: (i) conservation of solvent fluid, (ii) conservation of momentum, (iii) conservation of nutrients, and (iv) conservation of bacteria. The results of these equations, however, did not capture the heterogeneous distribution experimentally observed by Jemielita et al (2014) [ Figs.…”

Section: Gut Floramentioning

confidence: 99%

“…In the intestine, bacterial taxis can be triggered by nutrients, pH, temperature, oxygen, antimicrobials, and other factors. Yang et al (2018) mathematically expressed bacterial taxis as a potential field. This enabled reproduction of the heterogeneous distribution [ Fig.…”

Section: Gut Floramentioning

confidence: 99%

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Bacterial biomechanics—From individual behaviors to biofilm and the gut flora

Ishikawa

Omori

2020

APL Bioengineering

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Bacteria inhabit a variety of locations and play important roles in the environment and health. Our understanding of bacterial biomechanics has improved markedly in the last decade and has revealed that biomechanics play a significant role in microbial biology. The obtained knowledge has enabled investigation of complex phenomena, such as biofilm formation and the dynamics of the gut flora. A bottom-up strategy, i.e., from the cellular to the macroscale, facilitates understanding of macroscopic bacterial phenomena. In this Review, we first cover the biomechanics of individual bacteria in the bulk liquid and on surfaces as the base of complex phenomena. The collective behaviors of bacteria in simple environments are next introduced. We then introduce recent advances in biofilm biomechanics, in which adhesion force and the flow environment play crucial roles. We also review transport phenomena in the intestine and the dynamics of the gut flora, focusing on that in zebrafish. Finally, we provide an overview of the future prospects for the field.

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