What can we learn from late‐onset and occupational asthma?

Papi, Alberto; Corbetta, Lorenzo; Fabbri, Leonardo

doi:10.1046/j.1365-2222.1998.028s5174.x

Cited by 4 publications

(2 citation statements)

References 51 publications

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“…In a large cohort of older patients with asthma, more than 50% were diagnosed after the age of 50 years and 23% were diagnosed after 65 years (161). Asthma is underdiagnosed in older persons, particularly in highly functional older patients even when their PFTs demonstrate reversible airway obstruction (162,163).…”

Section: Epidemiologymentioning

confidence: 99%

Epidemiology and Management of Common Pulmonary Diseases in Older Persons

Akgün¹,

Crothers²,

Pisani³

2012

The Journals of Gerontology Series A: Biological Sciences and M

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Pulmonary disease prevalence increases with age and contributes to morbidity and mortality in older patients. Dyspnea in older patients is often ascribed to multiple etiologies such as medical comorbidities and deconditioning. Common pulmonary disorders are frequently overlooked as contributors to dyspnea in older patients. In addition to negative impacts on morbidity and mortality, quality of life is reduced in older patients with uncontrolled, undertreated pulmonary symptoms. The purpose of this review is to discuss the epidemiology of common pulmonary diseases, namely pneumonia, chronic obstructive pulmonary disease, asthma, lung cancer, and idiopathic pulmonary fibrosis in older patients. We will review common clinical presentations for these diseases and highlight differences between younger and older patients. We will also briefly discuss risk factors, treatment, and mortality associated with these diseases. Finally, we will address the relationship between comorbidities, pulmonary symptoms, and quality of life in older patients with pulmonary diseases.

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Section: Epidemiologymentioning

confidence: 99%

Epidemiology and Management of Common Pulmonary Diseases in Older Persons

Akgün¹,

Crothers²,

Pisani³

2012

The Journals of Gerontology Series A: Biological Sciences and M

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“…Studies of occupational asthma (6) and altitude (7) infer that the environment may directly affect symptoms of asthma. Accordingly, allergen avoidance has been advocated as an important aspect of asthma management, yet the evidence for its efficacy is limited (8).…”

mentioning

confidence: 99%

Effect of improved home ventilation on asthma control and house dust mite allergen levels

Wright

Howieson

McSharry

et al. 2009

Allergy

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Non‐Hodgkin's lymphoma among asthmatics exposed to pesticides

Lee

Cantor

Berzofsky

et al. 2004

Intl Journal of Cancer

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We conducted a pooled analysis of population-based casecontrol studies in Iowa, Minnesota and Nebraska to investigate whether asthma modifies risk of non-Hodgkin's lymphoma (NHL) associated with pesticide exposures. Cases (n ‫؍‬ 872) diagnosed with NHL from 1980 to 1986 and frequency-matched controls (n ‫؍‬ 2,381) randomly selected from the same geographic areas as the cases were included. Information on use of pesticides and history of asthma was based on interviews. Unconditional logistic regression was used to calculate ORs, adjusted for age, state and vital status. Of all subjects, 177 (45 cases, 132 controls) reported having been told by their doctor that they had asthma. Subjects with an asthma history had a nonsignificantly lower risk of NHL than nonasthmatics (OR ‫؍‬ 0.6, 95% CI 0.3-1.4), and there was no main effect of pesticide exposure (OR ‫؍‬ 1.0, 95% CI 0.8 -1.2). However, asthmatics tended to have larger ORs associated with exposure to pesticides than nonasthmatics. The OR among asthmatics was 1.8 (95% CI 1.1-3.2) for everuse of crop insecticides, 2.7 (95% CI 1.0 -7.2) for chlordane, 2.4 (95% CI 1.0 -5.7) for lindane and 3.7 (95% CI 1.3-10.9) for fonofos. Among nonasthmatics, ORs were 1.1 (0.9 -1.3), 1. Incidence and mortality rates for non-Hodgkin's lymphoma (NHL) have been increasing worldwide over the past several decades. 1 Although the reasons for this increase are not fully understood, NHL is known to be associated with a compromised immune system, particularly acquired or genetic immunodeficiencies. 2,3 Medical conditions related to more subtle immune alteration, such as asthma and other allergic conditions, have also been studied as potential risk factors for NHL. 4 -10 These reports have described a decreased risk for NHL among persons with a history of asthma or allergies, 4,5 no association 6 -8 or an increase in risk. 9,10 Exposure to pesticides has also been suggested as a possible risk factor for NHL. [11][12][13][14][15] Pesticides may increase cancer risk by altering the immune system. 16 -19 Because both asthma and pesticide exposure may change the risk of NHL by immunologic alterations, we investigated the relation between pesticide exposure, asthma and risk of NHL. MATERIAL AND METHODS Study populationWe pooled data from 2 population-based case-control studies of NHL in 3 midwestern states in the United States, which have been described in detail previously. 20,21 In Iowa and Minnesota, all newly diagnosed cases of NHL among white men aged Ն30 were ascertained from records of the Iowa State Health Registry and a special surveillance system of Minnesota hospitals and pathology laboratories from 1980 to 1983 (n ϭ 530). In Nebraska, all cases of NHL diagnosed between July 1983 and June 1986 among white men and women aged Ն21 in 45 eastern counties were identified through the Nebraska Lymphoma Study Group and area hospitals (n ϭ 346). All cases were reviewed by pathologists, and only histologically confirmed cases were included in this analysis. Controls were randomly selected from ...

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What can we learn from late‐onset and occupational asthma?

Cited by 4 publications

References 51 publications

Epidemiology and Management of Common Pulmonary Diseases in Older Persons

Epidemiology and Management of Common Pulmonary Diseases in Older Persons

Effect of improved home ventilation on asthma control and house dust mite allergen levels

Non‐Hodgkin's lymphoma among asthmatics exposed to pesticides

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