What can we learn from glucocorticoid administration in fish? Effects of cortisol and dexamethasone on intermediary metabolism of gilthead seabream (Sparus aurata L.)

Jerez-Cepa, Ismael; Gorissen, Marnix; Mancera, Juan Miguel; Ruíz-Jarabo, Ignacio

doi:10.1016/j.cbpa.2019.01.010

Cited by 38 publications

(28 citation statements)

References 73 publications

(88 reference statements)

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“…In the liver, cortisol also induces energy substrate repartitioning to cope with the enhanced energy demand associated with stressor exposure 48 . However, the roles of basal level of cortisol in fish under non-stressed conditions remain not completed understood 49 . In this regard, chronic oral administration of cortisol to gilthead seabream leads to higher energy expenditure and lower growth rate, increased hepatic triglycerides content and enhanced amino acid catabolism and gluconeogenesis in muscle 49 .…”

Section: Discussionmentioning

confidence: 99%

“…However, the roles of basal level of cortisol in fish under non-stressed conditions remain not completed understood 49 . In this regard, chronic oral administration of cortisol to gilthead seabream leads to higher energy expenditure and lower growth rate, increased hepatic triglycerides content and enhanced amino acid catabolism and gluconeogenesis in muscle 49 . Conversely, low level of cortisol may stimulate GH-induced IGF-1 expression in fish hepatocytes 50 , protein synthesis (i.e.…”

Section: Discussionmentioning

confidence: 99%

“…Conversely, low level of cortisol may stimulate GH-induced IGF-1 expression in fish hepatocytes 50 , protein synthesis (i.e. somatic growth), and deposition of hepatic glycogen and lipid in the muscle of fish 49 , 51 , 52 . These effects may be exerted by supplementation with microalgae-based products in our study, as suggested by the higher feed efficiency, higher hepatic glycogen content, and higher triglyceride levels in muscle of 1% LB Gb and 1% LB Gh fed fish.…”

Section: Discussionmentioning

confidence: 99%

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Low dietary inclusion of nutraceuticals from microalgae improves feed efficiency and modifies intermediary metabolisms in gilthead sea bream (Sparus aurata)

Perera

Sánchez-Ruiz

Sáez

et al. 2020

Sci Rep

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The aim of this work was to evaluate two functional feeds for the gilthead seabream, Sparus aurata, containing low inclusion of two microalgae-based products (LB-GREENboost, LBGb; and LB-GUThealth, LBGh). Fish (12–13 g) were fed for 13 weeks a control diet or one of the four diets supplemented with both products at 0.5% or 1%. LBGb and LBGh did not affect specific growth rate or survival, but increased feed efficiency by decreasing feed intake and enlarging the intestines. LBGb increased hepatosomatic index and reduced cortisol levels in plasma, while both products lowered plasma lactate. Extensive metabolite and metabolic enzyme profiling revealed that microalgae supplementations, especially 1% LBGh: (i) decrease plasma lactate and increase hepatic glycogen, (ii) reduce hepatic gluconeogenesis, (iii) enhance hepatic lipogenic activity and lipid secretion, (iv) led fish to double triglyceride content in muscle and to stimulate its lipid oxidative capacity, and (v) increase the content of monounsaturated fatty acids and the omega-3 alpha-linolenic acid in muscle. This study demonstrates that both microalgae-based products are suited to improve feed efficiency and orchestrate significant changes in the intermediary metabolism in gilthead seabream juveniles.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Low dietary inclusion of nutraceuticals from microalgae improves feed efficiency and modifies intermediary metabolisms in gilthead sea bream (Sparus aurata)

Perera

Sánchez-Ruiz

Sáez

et al. 2020

Sci Rep

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“…The literature on physiological stress biomarkers in different cultured species and husbandry conditions is extensive and constantly increasing. Classical stress parameters are related to the effects derived from cortisol actions [50,61,107], and heat shock proteins as cellular responses [108]. Hypoxia and air exposure due to handling are common acute stress situations in aquaculture.…”

Section: Teleostsmentioning

confidence: 99%

Physiology: An Important Tool to Assess the Welfare of Aquatic Animals

Jerez-Cepa

Ruíz-Jarabo

2021

Biology

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The assessment of welfare in aquatic animals is currently under debate, especially concerning those kept by humans. The classic concept of animal welfare includes three elements: The emotional state of the organism (including the absence of negative experiences), the possibility of expressing normal behaviors, and the proper functioning of the organism. While methods for evaluating their emotions (such as fear, pain, and anguish) are currently being developed for aquatic species and understanding the natural behavior of all aquatic taxa that interact with humans is a task that requires more time, the evaluation of internal responses in the organisms can be carried out using analytical tools. This review aims to show the potential of the physiology of crustaceans, cephalopods, elasmobranchs, teleosts, and dipnoans to serve as indicators of their wellbeing. Since the classical methods of assessing welfare are laborious and time-consuming by evaluation of fear, pain, and anguish, the assessment may be complemented by physiological approaches. This involves the study of stress responses, including the release of hormones and their effects. Therefore, physiology may be of help in improving animal welfare.

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“…The effects of DEXA on aquatic organisms, especially lower-tier organisms, including bacteria, D. magna, and algae, are limited. Available data suggest potential deleterious effects of DEXA on organisms at different levels of organization, including bacteria [42,43], Daphnia magna [44], fish [45][46][47], and algae [44,48]. Moreover, whether their low environmental concentrations can induce acute and chronic effects on humans, through drinking water, for example, remain an open scientific inquiry.…”

Section: Challenges Of Dexa In Aquatic Systemsmentioning

confidence: 99%

Occurrence, Fate, Effects, and Risks of Dexamethasone: Ecological Implications Post-COVID-19

Musee

Kebaabetswe

Tichapondwa

et al. 2021

IJERPH

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The recent outbreak of respiratory syndrome-coronavirus-2 (SARS-CoV-2), which causes coronavirus disease (COVID-19), has led to the widespread use of therapeutics, including dexamethasone (DEXA). DEXA, a synthetic glucocorticoid, is among the widely administered drugs used to treat hospitalized COVID-19 patients. The global COVID-19 surge in infections, consequent increasing hospitalizations, and other DEXA applications have raised concerns on eminent adverse ecological implications to aquatic ecosystems. Here, we aim to summarize published studies on DEXA occurrence, fate, and effects on organisms in natural and engineered systems as, pre-COVID, the drug has been identified as an emerging environmental contaminant. The results demonstrated a significant reduction of DEXA in wastewater treatment plants, with a small portion, including its transformation products (TPs), being released into downstream waters. Fish and crustaceans are the most susceptible species to DEXA exposure in the parts-per-billion range, suggesting potential deleterious ecological effects. However, there are data deficits on the implications of DEXA to marine and estuarine systems and wildlife. To improve DEXA management, toxicological outcomes of DEXA and formed TPs should entail long-term studies from whole organisms to molecular effects in actual environmental matrices and at realistic exposure concentrations. This can aid in striking a fine balance of saving human lives and protecting ecological integrity.

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What can we learn from glucocorticoid administration in fish? Effects of cortisol and dexamethasone on intermediary metabolism of gilthead seabream (Sparus aurata L.)

Cited by 38 publications

References 73 publications

Low dietary inclusion of nutraceuticals from microalgae improves feed efficiency and modifies intermediary metabolisms in gilthead sea bream (Sparus aurata)

Low dietary inclusion of nutraceuticals from microalgae improves feed efficiency and modifies intermediary metabolisms in gilthead sea bream (Sparus aurata)

Physiology: An Important Tool to Assess the Welfare of Aquatic Animals

Occurrence, Fate, Effects, and Risks of Dexamethasone: Ecological Implications Post-COVID-19

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