What are we missing? Three cases of severe COVID-19 pneumonia with negative testing

Siddiqui, Aisha; Singh, Sukhdev; Khan, Zohaib; Foster, Allison; Atere, Muhammed; Nfonoyim, Jay

doi:10.1177/2050313x20965410

Cited by 1 publication

(1 citation statement)

References 16 publications

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“…All of them had deterioration in clinical picture and developed respiratory failure during hospitalization. Repeated RT-PCR test was positive from endotracheal sputum sample, endotracheal sample, and nasopharyngeal sample respectively in those three cases [23]. The interval between the initial negative to positive RT-PCR in our case was 5 days.…”

Section: Discussionmentioning

confidence: 44%

Delayed RT-PCR Time-To-Positivity in an adult with SARS-CoV-2 Infection

Bunawan¹,

Mokoagow

Djojo

et al. 2021

J Infect Dev Ctries

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Early diagnosis is among the crucial measures to control the spread of SARS-CoV-2 infection. To date, reverse transcription polymerase chain reaction (RT-PCR) is the gold standard for COVID-19 testing, but various factors can affect its performance leading to false negative results. Hereby we present a patient with a high clinical suspicion for COVID-19 and had multiple negative RT-PCR results over 5 days. A 22-year-old woman presented with fever, dry cough, nausea, myalgia, headache, and mild dyspnea. Eleven days before, she was in close contact with her father who had tested positive for COVID-19. RT-PCR on nasopharyngeal and oropharyngeal swabs were performed on day 8, 9, and 12 of illness which all came back negative even after she started having a worsening dyspnea and showing an increased lung opacity from radiographic findings on day 11 of illness. Interestingly, her rapid antibody test (VivaDiag™ COVID-19 IgM/IgG rapid test by VivaChek Biotech (HangZhou,China) was positive for anti-SARS-CoV-2 Ig M and Ig G. Due to the worsening condition, she was referred to a tertiary hospital where her RT PCR result was positive on day 13 of illness. After 28 days from her first symptom, she was discharged from the hospital with improved symptoms and chest X-ray. As conclusions, in patients with high suspicion of COVID-19, repeat swab tests are mandatory if previous tests were negative. The diagnosis and treatment plan of COVID-19 should not solely be based on RT-PCR, but also consider the patient’s history, symptoms, laboratory result, and radiographic findings.

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Section: Discussionmentioning

confidence: 44%