What are the late effects of older gastric cancer survivors? A scoping review

Jeon, Misun; Youn, Nayung; Kim, Sang Hee

doi:10.1016/j.apjon.2022.100113

Cited by 2 publications

(2 citation statements)

References 50 publications

(57 reference statements)

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“…Participant eligibility criteria included having survived gastric cancer for at least five years, with a primary diagnosis of gastric cancer between 2011 and 2017, and having undergone either gastrectomy or endoscopic submucosal dissection (ESD). GCSs who were 65 years of age or older at the time of cancer diagnosis were categorized as older individuals [ 16 ]. Exclusion criteria included gastric cancer recurrence or death within five years of gastrectomy or ESD, and non-therapeutic gastrectomy (e.g., ESD for reasons other than gastric cancer or gastrectomy for the control of symptoms such as perforation, bleeding, or obstruction).…”

Section: Methodsmentioning

confidence: 99%

Long-term late effects in older gastric cancer survivors: Survival analysis using Cox hazard regression model by retrospective electronic health records

Jeon,

Jang,

Jeon

et al. 2023

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Purpose Because the population of older gastric cancer survivors (GCSs) is growing, understanding the long-term late effects experienced by these GCSs and their impact on survival outcomes is crucial for optimizing survivorship care. This study aims to identify and characterize these effects and investigate their association with survival outcomes. Methods A retrospective analysis of electronic health records was conducted on 9,539 GCSs diagnosed between 2011 and 2017. The GCSs were divided into two age groups (< 65 and ≥ 65 years) and the long-term late effects were categorized by age using Cox proportional hazard models. The impact of clinical factors and age-specific late effects on survival was evaluated in the older GCSs. Results Among the total GCSs, 37.6% were over and 62.4% were under 65 years of age. Significant differences between the age groups were observed in the cumulative hazard ratios (HRs) for iron and vitamin B12 levels and prognostic nutritional index (PNI) scores. In older GCSs, abnormal iron levels (HR 1.98, 95% CI 1.16–3.41, p = .013) and poor PNI scores (HR 1.59, 95% CI 1.03–2.47, p = .038) were associated with poorer survival outcomes. Additionally, being female was identified as a risk factor for lower survival rates (if male, HR 0.42, 95% CI 0.18–0.98, p = .045). Conclusion This study highlights the typical long-term late effects experienced by older GCSs. By tailoring survivorship care to address nutritional-, age-, and gender-related factors, the overall survival and quality of life of older GCSs can be improved.

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Section: Methodsmentioning

confidence: 99%

Long-term late effects in older gastric cancer survivors: Survival analysis using Cox hazard regression model by retrospective electronic health records

Jeon,

Jang,

Jeon

et al. 2023

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“…In fact, they are not always appropriate for use in China, due to social, economic, and cultural differences between developed and developing countries (20). In particular, older cancer patients have a high risk of occurrence of comorbidities, geriatric syndromes, and disability, which significantly reduced the HRQoL of patients and caused catastrophic expenses (21). In order to alleviate medical economics burdens for older adults with cancer in China, it is essential to gain a thorough understanding of cancer-related financial hardship and its effects.…”

Section: Introductionmentioning

confidence: 99%

The development and validation of a patient-reported outcome measure to assess financial hardship among older cancer survivors in China: hardship and recovery with distress survey

Liu

Zhang

et al. 2023

Front. Oncol.

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BackgroundFinancial hardship has been described as a patient’s economic experiencefollowing cancer-related treatment. Standardized patient-reported outcome measures(PROM) to assess this distress has not been well-studied, especially among older cancer survivors.ObjectiveThe aim of this study was to develop and validate PROM for assessing the financial hardship of older cancer survivors in China.MethodsItems were generated using qualitative interviews and literature review. Items were screened based on Delphi expert consultation and patients’ opinions. Item response theory (IRT) and classical test theory (CTT) were used to help reduce items. Retained items formed a pilot instrument that was subjected to psychometric testing. A cut-off score for the new instrument for predicting poor quality of life was identified by receiver operating characteristic (ROC) analysis.ResultsQualitative interviews and literature review generated 135 items, which were reduced to 60 items because of redundancy. Following Delphi expert consultation and patients’ evaluation, 24 items with high importance were extracted. Sixteen items were selected due to satisfactory statistical analysis based on CTT and IRT. Ten items were retained and comprised 2 domains after loadings in exploratory factor analysis (EFA). Internal consistency was satisfactory (α = 0.838). Test-retest reliability was good (intraclass correlation, 0.909). The ROC analysis suggested that the cut-off of 18.5 yielded an acceptable sensitivity and specificity.ConclusionsThe PROM for Hardship and Recovery with Distress Survey (HARDS) consists of 10 items that specifically reflect the experiences of financial hardship among older Chinese cancer survivors, and it also showed good reliability and validity in clinical settings.

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What are the late effects of older gastric cancer survivors? A scoping review

Cited by 2 publications

References 50 publications

Long-term late effects in older gastric cancer survivors: Survival analysis using Cox hazard regression model by retrospective electronic health records

Long-term late effects in older gastric cancer survivors: Survival analysis using Cox hazard regression model by retrospective electronic health records

The development and validation of a patient-reported outcome measure to assess financial hardship among older cancer survivors in China: hardship and recovery with distress survey

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