What are the high risk periods for incident substance use and transitions to abuse and dependence? Implications for early intervention and prevention

Wittchen, Hans‐Ulrich; Behrendt, Silke; Höfler, Michael; Perkonigg, Axel; Lieb, Roselind; Bühringer, Gerhard; Beesdo, Katja

doi:10.1002/mpr.254

Cited by 157 publications

(111 citation statements)

References 38 publications

Supporting

Mentioning

101

Contrasting

Unclassified

Order By: Relevance

“…Sensitivity to reward has been shown to be associated with a stronger physiological response to alcohol intake as well as an increase in conditioned responses to alcohol cues (Brunelle et al, 2004). In addition, early initiation of alcohol intake was found to be associated with an elevated risk for the development of alcohol use disorder (Behrendt et al, 2009), specifically in adolescence, since this period was characterized as a high risk period for first alcohol use and the transition to alcohol abuse and dependence (Wittchen et al, 2008;Swendsen et al, 2009). …”

Section: Discussionmentioning

confidence: 99%

“…Early initiation of alcohol intake, even at very low levels of alcohol use, was found to be associated with an elevated risk for the development of alcohol use disorder (Behrendt et al, 2009). Specifically, adolescence was characterized as a high risk period for first alcohol use and the transition to alcohol abuse and dependence (Wittchen et al, 2008;Swendsen et al, 2009). Neurobiological factors such as deficient recruitment of motivational circuitry by non-drug rewards (Ratsma et al, 2002) and psychosocial factors such as adverse life events resulting from deviant and risky behavior (eg, Clark et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Determinants of Early Alcohol Use In Healthy Adolescents: The Differential Contribution of Neuroimaging and Psychological Factors

Nees

Tzschoppe

Patrick

et al. 2011

Neuropsychopharmacol

126

View full text Add to dashboard Cite

Individual variation in reward sensitivity may have an important role in early substance use and subsequent development of substance abuse. This may be especially important during adolescence, a transition period marked by approach behavior and a propensity toward risk taking, novelty seeking and alteration of the social landscape. However, little is known about the relative contribution of personality, behavior, and brain responses for prediction of alcohol use in adolescents. In this study, we applied factor analyses and structural equation modeling to reward-related brain responses assessed by functional magnetic resonance imaging during a monetary incentive delay task. In addition, novelty seeking, sensation seeking, impulsivity, extraversion, and behavioral measures of risk taking were entered as predictors of early onset of drinking in a sample of 14-year-old healthy adolescents (N ¼ 324). Reward-associated behavior, personality, and brain responses all contributed to alcohol intake with personality explaining a higher proportion of the variance than behavior and brain responses. When only the ventral striatum was used, a small non-significant contribution to the prediction of early alcohol use was found. These data suggest that the role of reward-related brain activation may be more important in addiction than initiation of early drinking, where personality traits and reward-related behaviors were more significant. With up to 26% of explained variance, the interrelation of reward-related personality traits, behavior, and neural response patterns may convey risk for later alcohol abuse in adolescence, and thus may be identified as a vulnerability factor for the development of substance use disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Determinants of Early Alcohol Use In Healthy Adolescents: The Differential Contribution of Neuroimaging and Psychological Factors

Nees

Tzschoppe

Patrick

et al. 2011

Neuropsychopharmacol

126

View full text Add to dashboard Cite

show abstract

“…Model IIA : as model II but with additional adjustment for anxiety disorders that predicted the respective alcohol use disorder (AUD) in model II and for an aggregated variable including generalized anxiety disorder, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), agoraphobia without history of panic disorder and panic disorder. gender differences in the speed of transition to AD (Wagner & Anthony, 2007 ;Wittchen et al 2008). Nicotine dependence and cannabis use disorders were not associated with more rapid transitions to AUD, possibly because their main incidence phases overlap with those of AUD (Wittchen et al 2008).…”

Section: Earlier Pmd Onsetmentioning

confidence: 95%

“…Female gender has been linked with faster transitions to alcohol problems (Randall et al 1999), but more recent studies found no or little evidence for a faster AUD development in women (Wagner & Anthony, 2007 ;Wittchen et al 2008). We hypothesized that there are no gender differences in the speed of transition to AUD.…”

Section: Introductionmentioning

confidence: 91%

The role of mental disorders in the risk and speed of transition to alcohol use disorders among community youth

Behrendt¹,

Beesdo‐Baum²,

Zimmermann

et al. 2010

Psychol. Med.

Self Cite

View full text Add to dashboard Cite

Background. Among adolescents and young adults with DSM-IV alcohol use disorders (AUDs), there are interindividual differences in the speed of transition from initial alcohol use (AU) to AUD. AUDs are highly co-morbid with other mental disorders. The factors associated with rapid transition from first AU to AUD remain unknown and the role of mental disorders in rapid transitions is unclear. Given this background we examined (1) whether prior anxiety, mood, externalizing and non-alcohol substance use disorders are related to the risk and speed of transition from first AU to DSM-IV alcohol abuse (AA) and alcohol dependence (AD) and (2) whether early age of onset of prior mental disorders (PMDs) is a promoter of rapid transition.Method. A total of 3021 community subjects (97.7 % lifetime AU) aged 14-24 years at baseline were followed up prospectively for up to 10 years. AU and mental disorders were assessed with the DSM-IV/M-CIDI.Results. Among subjects with lifetime AU, several PMDs, such as specific phobia, bipolar disorder and nicotine dependence, were associated with an increased risk of AUD independent of externalizing disorders. Associations of PMDs with the speed of transition to AUDs were mostly weak and inconsistent. Only social phobia and externalizing disorders were associated with faster transitions to AD even after adjustment for other PMDs. Earlier age of onset of PMD was not associated with rapid transition.Conclusions. Mental disorders are associated with the risk of AUD. With the possible exception of social phobia and externalizing disorders, they do not promote rapid transition, even if they occur particularly early. Future research needs to identify factors relevant to rapid transition to AUD.

show abstract

“…In order to prevent (party-)drug use or reduce its harmful effects, interventions are often targeted at young adults, most notably vocational, college, and university students, as drug initiation and regular use peak around young adulthood (Arria et al, 2008;Arria, Vincent, & Caldeira, 2009;Dennhardt & Murphy, 2013;Wittchen et al, 2008). However, descriptions of party-drug use among students, including the use of trending partydrugs such as NPS, are lacking.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Psychosocial Correlates of Party-Drug Use and Associated Problems among University Students in the Netherlands

Kunst

Gebhardt

2018

Substance Use & Misuse

View full text Add to dashboard Cite

Background: Recent developments in drug use patterns call for an investigation of current party-drug use and associated problems among college students, who appear to be an important target population for harm reduction interventions. Objectives: In addition to reporting on party-drug use prevalence, we investigated whether initial use and continuation of party-drug use among students was associated with demographic, personality and psychosocial factors. Methods: An online questionnaire was administered to 446 students from a Dutch university, inquiring about party-drug use, demographic characteristics, social norms and personality (big five, impulsiveness, aggression). Univariate and multivariate bootstrapped linear regression analyses were used. Results: Of all students, 22.9% indicated having used party-drugs at least once, with a notable sex difference (39.2% of men vs. 16.2% of women). In contrast to the reported trends in Dutch nightlife, GHB was used rarely (lifetime 1.6%) and new psychoactive substances (NPS; 6.7%) appeared almost equally popular as amphetamines (7.6%) and cocaine (7%). Mild health/psychosocial problems (e.g., doing embarrassing things, feeling unwell) were common (65%), whereas serious problems (e.g., being hospitalized) were rare. Neuroticism, extraversion, conscientiousness and impulsiveness were associated with lifetime but not regular party-drug use. Of all predictors, lifetime and regular party-drug use were most strongly related to lenient injunctive and descriptive norms in friends, and a low motivation to comply with parents. Conclusions: Our findings indicate that harm reduction/preventive interventions might profit from focusing on social norms, and targeting students who are highly involved in a pro-party-drug environment while experiencing less parental influence.

show abstract

What are the high risk periods for incident substance use and transitions to abuse and dependence? Implications for early intervention and prevention

Cited by 157 publications

References 38 publications

Determinants of Early Alcohol Use In Healthy Adolescents: The Differential Contribution of Neuroimaging and Psychological Factors

Determinants of Early Alcohol Use In Healthy Adolescents: The Differential Contribution of Neuroimaging and Psychological Factors

The role of mental disorders in the risk and speed of transition to alcohol use disorders among community youth

Prevalence and Psychosocial Correlates of Party-Drug Use and Associated Problems among University Students in the Netherlands

Contact Info

Product

Resources

About