What are the Factors Affecting Patient Positioning Accuracy After Image Fusion Guided Target Localization in Stereotactic Body Radiosurgery?

Jin, Jian-Yue; Ryu, Samuel; Sheim, S.; Faber, Kathleen; Chen, Q.; Ajlouni, Munther; Movsas, Benjamin

doi:10.1016/j.ijrobp.2007.07.2115

Cited by 1 publication

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“…For such patients, high-precision radiotherapy techniques, such as stereotactic radiosurgery, stereotactic body radiotherapy (SBRT), or intensity-modulated radiotherapy, may be considered, particularly for patients with involvement of only 1 or 2 spinal levels. [16][17][18] These high-precision radiotherapy techniques spare sections of the spinal cord, which results in less radiation-induced toxicity. When hypofractionated regimens are used, high-precision radiotherapy techniques may further enhance the therapeutic ratio.…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors for functional outcome and survival after reirradiation for in‐field recurrences of metastatic spinal cord compression

Rades

Rudat

Veninga

et al. 2008

Cancer

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Objective: We examined whether glucose transporter 1 (GLUT1) deficiency causes common idiopathic generalized epilepsies (IGEs). Methods: The IGEs are common, heritable epilepsies that usually follow complex inheritance; currently little is known about their genetic architecture. Previously considered rare, GLUT1 deficiency, due to mutations in SLC2A1, leads to failure of glucose transport across the blood–brain barrier and inadequate glucose for brain metabolism. GLUT1 deficiency was first associated with an encephalopathy and more recently found in rare dominant families with epilepsy and paroxysmal exertional dyskinesia (PED). Five hundred four probands with IGEs and 470 controls underwent SLC2A1 sequencing. Glucose transport was assayed following expression of SLC2A1 variants in Xenopus oocytes. All available relatives were phenotyped, and SLC2A1 was sequenced. Results: Functionally validated mutations in SLC2A1 were present in 7 of 504 (1.4%) probands and 0 of 470 controls. PED, undiagnosed prior to study, occurred in 1 proband and 3 of 13 relatives with mutations. The IGEs in probands and relatives were indistinguishable from typical IGE. Three cases (0.6%) had mutations of large functional effect and showed autosomal dominant inheritance or were de novo. Four (0.8%) cases had a subtle functional effect; 2 showed possible dominant inheritance, and 2 did not. These alleles leading to subtle functional impairment may contribute to complex, polygenic inheritance of IGE. Interpretation: SLC2A1 mutations contribute to approximately 1% of IGE both as a dominant gene and as a susceptibility allele in complex inheritance. Diagnosis of GLUT1 deficiency has important treatment (ketogenic diet) and genetic counseling implications. The mechanism of restricted glucose delivery differs from the current focus on IGEs as ion channel disorders. ANN NEUROL 2012;72:807–815

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Section: Discussionmentioning

confidence: 99%