What are the emerging concepts and challenges in NANO? Nanoarchitectonics, hand-operating nanotechnology and mechanobiology

Ariga, Katsuhiko; Minami, Kosuke; Ebara, Mitsuhiro; Nakanishi, Jun

doi:10.1038/pj.2016.8

Cited by 195 publications

(84 citation statements)

References 174 publications

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“…[18][19][20][21][22][23] This makes LbL multilayers containing different dyes ideally suited for studying FRET processes between different dyes.T he groups of Jonas and Reynolds have systematically studied the FRET processes between multilayer films containing donor and acceptor dyes. [18][19][20][21][22][23] This makes LbL multilayers containing different dyes ideally suited for studying FRET processes between different dyes.T he groups of Jonas and Reynolds have systematically studied the FRET processes between multilayer films containing donor and acceptor dyes.…”

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confidence: 99%

Multilayer Microcapsules for FRET Analysis and Two‐Photon‐Activated Photodynamic Therapy

et al. 2016

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Microcapsules obtained by layer-by-layer assembly provide a good platform for biological analysis owing to their component diversity, multiple binding sites, and controllable wall thickness. Herein, different assembly species were obtained from two-photon dyes and traditional photosensitizers, and further assembled into microcapsules. Fluorescence resonance energy transfer (FRET) was shown to occur between the two-photon dyes and photosensitizers. Confocal laser scanning microscopy (CLSM) with one- and two-photon lasers, fluorescence lifetime imaging microscopy (FLIM), and time-resolved fluorescence spectroscopy were used to analyze the FRET effects in the microcapsules. The FRET efficiency could easily be controlled through changing the assembly sequence. Furthermore, the capsules are phototoxic upon one- or two-photon excitation. These materials are thus expected to be applicable in two-photon-activated photodynamic therapy for deep-tissue treatment.

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confidence: 99%

Multilayer Microcapsules for FRET Analysis and Two‐Photon‐Activated Photodynamic Therapy

et al. 2016

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“…The interfacial performance is influenced not only by components of composites, but also by the micro-nanoarchitectonics of interface, including the dispersion and alignment of fillers, morphology and contact area of filler/filler or filler/polymer interface, interaction between fillers and polymer matrix and so on [15,16]. The micro-nanostructure of TCF within polymer matrix may play a more important role in thermal conductive nanocomposites [17].…”

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confidence: 98%

The influence of compression molding techniques on thermal conductivity of UHMWPE/BN and UHMWPE/(BN + MWCNT) hybrid composites with segregated structure

Ren

Hou

Ren

et al. 2016

Composites Part A: Applied Science and Manufacturing

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“…Within the wide range of applications in nanoarchitectonics, one promising field is the controlled topical drug delivery by specifically tailored nanoparticles [34,35]. It is widely accepted that the topical use of chitosan nanoparticles may improve drug bioavailability by prolonging the residence time of drugs applied [36].…”

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confidence: 99%

Chitosan Coating on Silica-Modified Polymethyl Methacrylate for Dental Applications

et al. 2017

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Abstract:Chitosan is a cationic natural polymer that is widely used as a topical dressing in wound management. Temporary coatings of removable denture bases with chitosan might be useful as supportive treatment in oral medicine. The aim of this study was to analyze the thickness, uniformity, and adhesive strength of chitosan coatings on simulated denture bases made from polymethyl methacrylate (PMMA). According to a standardized protocol, 20 PMMA cylinders (13 mm diameter, 5 mm in height) as well as 20 cubes (a = 25 mm) with intaglio U-shaped profiles were manufactured to simulate average sized alveolar ridges. Cylinders as well as cubes were divided into four test series with n = 5 each. After sandblasting with silica-modified alumina, one frontal surface of the PMMA cylinders and the intaglio surfaces of the U-shaped profiles was coated with chitosan acetate solution according to the following protocols: one layer of 2% chitosan acetate solution (test series I), one layer of 4% chitosan acetate solution (test series II), two layers of 2% chitosan acetate solution (test series III), and two layers of 4% chitosan acetate solution (test series IV). After drying and neutralization with NaOH, each cube was cut transversely and the coating thickness across the U-shaped profile assessed with a light microscope. Adhesive strength was evaluated by simulated tooth brushing and the loss of chitosan coating was evaluated qualitatively. Statistical analysis used Friedman ANOVA test for dependent samples and Kruskal-Wallis test for independent samples, post-hoc Dunn's test (p < 0.05), and binomial test (p = 0.05). The mean chitosan coating thicknesses in the depth of the U-profiles were 71 µm (test series I), 77 µm (test series II), 121 µm (test series III), and 517 µm (test series VI). The thickness continuously decreased with rising angulation of the U-profile side walls. In test series I, the chitosan coating thickness significantly dropped above a 30 • angulation of the U-profile side walls. In test series II to IV, the chitosan thickness drop was not statistically significant at angulations of 30 • and 60 • , but was at 90 • angulation of the U-profile side walls. Adhesion strength was rated fair to good and did not differ significantly among the four test series. The coating technique described revealed chitosan layers with overall good adhesion strength but differing thicknesses. Coatings with one or two layers of 4% chitosan acetate solution allowed a relatively uniform chitosan thickness and thus might be usable in oral medicine.

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What are the emerging concepts and challenges in NANO? Nanoarchitectonics, hand-operating nanotechnology and mechanobiology

Cited by 195 publications

References 174 publications

Multilayer Microcapsules for FRET Analysis and Two‐Photon‐Activated Photodynamic Therapy

Multilayer Microcapsules for FRET Analysis and Two‐Photon‐Activated Photodynamic Therapy

The influence of compression molding techniques on thermal conductivity of UHMWPE/BN and UHMWPE/(BN + MWCNT) hybrid composites with segregated structure

Chitosan Coating on Silica-Modified Polymethyl Methacrylate for Dental Applications

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