What are the direct costs of sepsis treatment in Brazilian ICUs?

Abstract

Third International Symposium on Intensive Care and Emergency Medicine for Latin America plays a critical role in the inflammatory response and, potentially, a polymorphism in IRAK1 may alter the immune response impacting clinical outcome. P2 Gene expression and intracellular NF-κ κB activation after HMGB1 and LPS stimuli in neutrophils from septic patients

An Objective Screening Method for Major Depressive Disorder Using Logistic Regression Analysis of Heart Rate Variability Data Obtained in a Mental Task Paradigm

“…The performance of the LRA was evaluated using Nagelkerke’s R 2 and Cox and Snell’s R 2 tests (21). Moreover, to find the optimal cutoff point with the highest sensitivity and specificity of LRA, a receiver operating characteristic (ROC) curve was adopted.…”

Estimativa do impacto econômico da implantação de um protocolo hospitalar para detecção e tratamento precoce de sepse grave em hospitais púbicos e privados do sul do Brasil

“…However, these analyses only address the direct costs of in-hospital treatment of septic patients. (2,7,8,18) Comparisons between the findings of the present study and those of previous studies should be made with caution, taking into account the fact that we evaluated a specific protocol for the early detection and initiation of treatment of septic patients in hospital wards, emergency rooms and ICUs in a small sample of patients of only two hospitals.…”

“…(6) From an economic standpoint, sepsis represents huge expenses for the health system, as well as a significant loss of productivity stemming from long hospital stays and the accompanying high rates of mortality. (7,8) Estimates indicate that the direct cost of sepsis in the United States is approximately $US17 billion per year, which represents only 30% of the total cost of the disease if the social costs are also considered. (2) Preventive measures, as well as the implementation of protocols for early detection and optimized treatment, are steps that aim to decrease morbidity and mortality rates and the costs associated with sepsis.…”

Análise da qualidade de vida após a alta hospitalar em sobreviventes de sepse grave e choque séptico

“…Há vários métodos de aferição de qualidade de vida pós-alta hospitalar em pacientes graves, dentre os quais podemos citar o SF- 36 (10). Pacientes que sobreviveram ao episódio séptico apresentam diminuição da qualidade de vida independentemente do método de aferição empregado (10).…”

“…Desse modo, o custo para a sociedade derivado da perda da produtividade individual e não oriunda apenas da mortalidade, mas também do comprometimento da qualidade de vida. Algumas análises econômicas disponíveis mostram que a padronização dos regimes terapêuticos reduz a mortalidade e o custo direto hospitalar relacionado à sepse (1,(36)(37)(38). Nesse sentido, é possível que a adoção de programas de reabilitação e reintegração desses indivíduos possa acelerar a recuperação da capacidade produtiva e reduzir o custo indireto da sepse à sociedade.…”