What are the determinants of antiretroviral therapy adherence among stable people living with HIV? A cross-sectional study in Cambodia

Tuot, Sovannary; Sim, Jian Wei; Nagashima-Hayashi, Michiko; Chhoun, Pheak; Teo, Alvin Kuo Jing; Prem, Kiesha; Yi, Siyan

doi:10.1186/s12981-023-00544-w

Cited by 2 publications

(1 citation statement)

References 46 publications

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“…Several studies highlighted the importance of adherence support programs, as many patients reported difficulties in maintaining consistent medication routines postswitch. Adherence remains a cornerstone of successful HIV treatment, emphasizing the need for comprehensive patient education and support services [22,23]. We observed that in our patients, pill burden was the major factor correlated with adherence.…”

Section: Discussionmentioning

confidence: 60%

Antiretroviral Therapy Switch in HIV-Infected Adults from a Regional HIV/AIDS Center in NE Romania

Loghin,

Rusu,

Vâţă

et al. 2024

Medicina

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Background and Objectives: Antiretroviral therapy (ART) has revolutionized the management of HIV infection, transforming it from a once-debilitating disease to a chronic, manageable condition. However, challenges such as treatment resistance, medication side effects, and long-term tolerability persist, prompting the exploration of novel therapeutic approaches. We aimed to highlight the characteristics and related comorbidities of HIV/AIDS cases in which the antiretroviral therapy was modified. Material and Methods: A cross-sectional clinical investigation was conducted on adults diagnosed with HIV/AIDS who were hospitalized at the “St. Parascheva” Clinical Hospital of Infectious Diseases in Iasi in the Northeastern region of Romania. The timeframe under investigation was 1 January 2023 to 30 June 2023. Results: In the Northeastern part of Romania, from a total of 1692 patients in the active records, there were a total of 148 recorded cases of antiretroviral therapy switch in HIV-infected patients. The main reason for the ART switch was the simplification of the ART regimen (82 cases, 55.40%), viro-immunological failure (16 cases, 10.66%), other disturbances correlated to the ART regimen, dyslipidemia (34 cases 22.97%), depression (3 cases, 2.02%), suicide attempt (1 case, 0.67%), new situations, including the appearance of pregnancy (3 cases 2.02%), and tuberculosis (9 cases, 6.08%). ART before the switch was represented by protease inhibitors that accounted for 84 cases (56.75%) of the ART switch. Following the therapy switch, integrase inhibitor-based ART single-tablet regimens accounted for 43.91% (65 cases) of all changeovers, with non-nucleoside reverse transcriptase inhibitor regimens coming in second, in 63 cases, 42.66%. Conclusions: ART switch as an experimental therapy offers a promising approach to optimizing HIV treatment outcomes. By focusing on viral suppression and immune reconstitution, addressing treatment challenges, and exploring novel ARV agents, ART switch strategies aim to improve the overall health and well-being of individuals living with HIV.

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Section: Discussionmentioning

confidence: 60%

Antiretroviral Therapy Switch in HIV-Infected Adults from a Regional HIV/AIDS Center in NE Romania

Loghin,

Rusu,

Vâţă

et al. 2024

Medicina

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Evaluating knowledge about HIV and discriminatory attitudes among Pakistani women of reproductive age using 2017–18 Demographic Health Survey data

Sameen,

Lakhdir,

Azam

et al. 2023

Sci Rep

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A prominent issue associated with HIV is the stigma around it owing to a lack of awareness. This study aimed to find the association between HIV and AIDS-related knowledge and discriminatory attitudes amongst Pakistani women of reproductive age using the 2017–18 Pakistani Demographic Health Survey (PDHS) data. We analyzed a sample of 3381 Pakistani women of reproductive age using ordinal logistic regression for complex survey data. Two composite variables were created using the HIV module to denote the respondents’ HIV-related knowledge and their attitude toward people living with HIV (PLHIV) and calculated using a scoring method. Additional variables included the respondents’ age, education level, socioeconomic status, residential setting, and HIV testing history. More than half (58.8%) of the respondents presented with a negative attitude toward PLHIV and 64.3% of the respondents had poor knowledge regarding the illness. In the multivariable analysis, knowledge about HIV and level of education reported significant associations with discriminatory attitudes. We concluded that the odds of individuals living in a rural setting and hailing from a low socioeconomic background presenting with a negative attitude towards PLHIV were 2.52 times (95% CI 1.07–5.89) higher as compared to those living in an urban setting from a high socioeconomic background.

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What are the determinants of antiretroviral therapy adherence among stable people living with HIV? A cross-sectional study in Cambodia

Cited by 2 publications

References 46 publications

Antiretroviral Therapy Switch in HIV-Infected Adults from a Regional HIV/AIDS Center in NE Romania

Antiretroviral Therapy Switch in HIV-Infected Adults from a Regional HIV/AIDS Center in NE Romania

Evaluating knowledge about HIV and discriminatory attitudes among Pakistani women of reproductive age using 2017–18 Demographic Health Survey data

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