What Are the Causes of Late-Life Depression?

Aziz, Rehan; Steffens, David C.

doi:10.1016/j.psc.2013.08.001

Cited by 242 publications

(198 citation statements)

References 104 publications

Supporting

Mentioning

179

Contrasting

Unclassified

Order By: Relevance

“…We did not localize the maximum load of WMHs, but other studies in LOD localized the increased lesion density to relevant regions [56,57,58]. Recent reviews of brain changes in late-life depression [[59], table13, [60,61,62]] concur in concluding that the structural neuroimaging literature shows the involvement of frontolimbic pathways in late-life depression, and this is particularly clear with late onset.…”

Section: Discussionmentioning

confidence: 84%

Neuroticism in Remitted Major Depression: Elevated with Early Onset but Not Late Onset of Depression

Gade

Kristoffersen²,

Kessing

2015

Psychopathology

View full text Add to dashboard Cite

Background: The personality trait of neuroticism is strongly related to depression, but depression is etiologically heterogeneous. Late-onset depression (LOD) may be more closely related to vascular factors, and previous studies of neuroticism in LOD versus early-onset depression (EOD) have not been consistent. Method: We examined neuroticism, extraversion and perceived stress in 88 fully remitted depressed patients with a mean age of 60 years and with a history of hospitalization for major depressive disorder. Patients were divided into those with onset after and those with onset before 50 years of age (LOD and EOD, respectively), and the two groups were compared both with each other and with matched control groups of healthy subjects. Results: EOD patients showed increased levels of neuroticism in comparison with both LOD and matched controls, who did not differ. The association between age of onset and neuroticism was confirmed in analyses based on age of depression onset as a continuous variable. Conclusion: Neuroticism may be an etiological factor in EOD but not or less so in LOD. This finding contributes to the growing evidence for etiological differences between early- and late-onset late-life depression.

show abstract

Section: Discussionmentioning

confidence: 84%

Neuroticism in Remitted Major Depression: Elevated with Early Onset but Not Late Onset of Depression

Gade

Kristoffersen²,

Kessing

2015

Psychopathology

View full text Add to dashboard Cite

show abstract

“…Los trastornos depresivos constituyen el principal factor predictivo de muerte por esta causa 21 , existiendo importantes diferencias según la edad, asociándose con mayor mortalidad, tanto por suicidio como por enfermedades somáticas, cuando suceden en edades avanzadas 22 . Debido a su relación es necesaria la exploración de síntomas depresivos ante la presencia de enfermedad crónica simultánea.…”

Section: Discussionunclassified

Características de la conducta suicida y factores asociados a su mortalidad en el ámbito hospitalario

Sendra‐Gutiérrez

Esteban-Vasallo

Domínguez‐Berjón

2018

Revista de Psiquiatría y Salud Mental

View full text Add to dashboard Cite

“…Losses such as grief, especially for the loss of spouse or child, were important factors. According to the psychodynamic theory, the incidence of depression as a reaction to grief is caused by the older adult's failure to express the negative emotions resulting from the loss and is most frequently observed in those who do not express their feelings adequately (15).…”

Section: Discussionmentioning

confidence: 99%

What Causes Late-Life Depression? A Qualitative Study of Depressed Iranian Older People

Roudsari

Foroughan

Shahboulaghi

et al. 2018

Iran J Psychiatry Behav Sci

View full text Add to dashboard Cite

Background: Depression is a major health problem in old age that is closely related to cultural and social contexts. Studies have shown a higher prevalence of geriatric depression in Iran. Objectives: This qualitative content analysis study aimed to explore the psychosocial factors related to the experience of late life depression in older people in Iran. Methods: This qualitative study with a directed content analysis approach was conducted in Tehran in 2015. First, a systematic search in major English and Persian data banks was carried out to develop an analysis matrix. The participants with maximum variations in demographic characteristics were recruited from psychiatric clinics, if they met inclusion criteria, which included: 1) age of 60 years and, and 2) diagnosis above of depression by a psychiatrist in the last six months. Semi-structured interviews were conducted up to reaching data saturation. The interviews were recorded, transcribed verbatim and transformed into meaning units and codes. The codes were then analyzing matrix and reviewed again to form new subcategories and categories. Results: Twelve old people participated in this study. Analyzing the data, 534 codes in 42 subcategories and 17categories led to six main themes which included: 1) transition of value system, 2) role changes, 3) life concerns, 4) inadequacy of social relations, 5) regrets, and 6) impaired health and function. Discussion: From the perspective of the depressed old people, recent changes in values and impaired social relations, made them feel lonely confronting life struggles and inevitable changes of roles, health status and function. Some context-based interventions such as community alertness and providing more formal support may be helpful in preventing late life depression.

show abstract

What Are the Causes of Late-Life Depression?

Cited by 242 publications

References 104 publications

Neuroticism in Remitted Major Depression: Elevated with Early Onset but Not Late Onset of Depression

Neuroticism in Remitted Major Depression: Elevated with Early Onset but Not Late Onset of Depression

Características de la conducta suicida y factores asociados a su mortalidad en el ámbito hospitalario

What Causes Late-Life Depression? A Qualitative Study of Depressed Iranian Older People

Contact Info

Product

Resources

About