Importance-Research indicates that e-cigarette use (vaping) among adolescents is associated with the initiation and progression of combustible cigarette smoking, yet the reasons for this association are unknown.Objective-To evaluate whether use of e-cigarettes with higher nicotine concentrations is associated with subsequent increases in the frequency and intensity of combustible cigarette smoking and vaping.Design/Setting/Participants-Prospective school-based cohort; surveys were administered in Spring (baseline, 10 th grade) and Fall (6-month follow-up, 11 th grade) 2015 among past 30-day vapers with available nicotine concentration data (N=181) from 10 high schools in the Los Angeles, CA metropolitan area. Exposure-Self-report of baseline e-cigarette nicotine concentration (i.e., none [0 mg/mL], low [1-5 mg/mL], medium [6-17 mg/mL] or high [18 mg/mL or greater]) typically used during the past 30-days. Main Outcome(s) and Measure(s)-Frequency of past 30-day combustible cigarette smoking and e-cigarette use (0 days [none], 1-2 days [infrequent], ≥ 3 days [frequent]) and daily smoking and vaping intensity (number of cigarettes smoked per day, number of vaping episodes per day and number of puffs per vaping episode) at 6-month follow-up.