What affects the biocompatibility of polymers?

Jurak, Małgorzata; Wiącek, Agnieszka Ewa; Ładniak, Agata; Przykaza, Kacper; Szafran, Klaudia

doi:10.1016/j.cis.2021.102451

Cited by 99 publications

(64 citation statements)

References 171 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Developing the analogy between the human cell membrane and the Nafion membrane, we note that there are a number of organic compounds that stimulate the permeability of various ions through the cation channels of the cell membrane. We can say that the Nafion polymer membrane is similar to synthetic biological polymer membranes; see the recent review [20]. In this regard, the alkaloid piperine (C 17 H 19 NO 3 ), which stimulates the conductivity of calcium [21] and potassium [22] ions in human cell channels, is of particular interest to study.…”

Section: Introductionmentioning

confidence: 99%

Stochastic Ultralow-Frequency Oscillations of the Luminescence Intensity from the Surface of a Polymer Membrane Swelling in Aqueous Salt Solutions

et al. 2022

View full text Add to dashboard Cite

Photoluminescence from the surface of a Nafion polymer membrane upon swelling in isotonic aqueous solutions and Milli-Q water has been studied. Liquid samples were preliminarily processed by electric pulses with a duration of 1 μs and an amplitude of 0.1 V using an antenna in the form of a flat capacitor; experiments on photoluminescent spectroscopy were carried out 20 min after this treatment. A typical dependence of the luminescence intensity, I, on the swelling time, t, obeys an exponentially decaying function. The characteristic decay time of these functions and the stationary level of luminescence intensity depend on the repetition rate of electrical pulses, and the obtained dependences are well reproduced. It transpired that, at certain pulse repetition rates, the dependence, I(t), is a random function, and there is no reproducibility. Stochastic effects are associated with a random external force of an electromagnetic nature that acts on a polymer membrane during swelling. The source of this random force, in our opinion, is low-frequency pulsations of neutron stars or white dwarfs.

show abstract

Section: Introductionmentioning

confidence: 99%

Stochastic Ultralow-Frequency Oscillations of the Luminescence Intensity from the Surface of a Polymer Membrane Swelling in Aqueous Salt Solutions

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Various decellularized fruit and vegetable -derived tissues as scaffolds have been investigated in vitro (Salehi et al, 2020;Contessi Negrini et al, 2020). Previously, there was a very complex foreign body reaction after implantation of foreign materials (Klopfleisch and Jung, 2017;Jurak et al, 2021), we also showed that foreign body reaction occurred after implantation of different patch materials. The new tissue capsuled the patch as early as day 7 after implantation (Bai et al, 2021c), the inflammatory response of surgical implantation deceased after 2 weeks, (de la Oliva et al, 2018), (Bai et al, 2017c) and the leaf patch also showed a similar healing process when compared to other patch materials (Bai et al, 2021a).…”

Section: Discussionmentioning

confidence: 78%

A Novel Plant Leaf Patch Absorbed With IL-33 Antibody Decreases Venous Neointimal hyperplasia

Xie

Bai

Sun

et al. 2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Introduction: We recently showed that a decellularized leaf scaffold can be loaded with polylactic-co-glycolic acid (PLGA)-based rapamycin nanoparticles, this leaf patch can then inhibit venous neointimal hyperplasia in a rat inferior vena cava (IVC) venoplasty model. IL-33 plays a role in the neointimal formation after vascular injury. We hypothesized that plant leaves can absorb therapeutic drug solution and can be used as a patch with drug delivery capability, and plant leaves absorbed with IL-33 antibody can decrease venous neointimal hyperplasia in the rat IVC venoplasty model.Method: A human spiral saphenous vein (SVG) graft implanted in the popliteal vein was harvested from a patient with trauma and analyzed by immunofluorescence. Male Sprague-Dawley rats (aged 6–8 weeks) were used to create the IVC patch venoplasty model. Plant leaves absorbed with rhodamine, distilled water (control), rapamycin, IL-33, and IL-33 antibody were cut into patches (3 × 1.5 mm2) and implanted into the rat IVC. Patches were explanted at day 14 for analysis.Result: At day 14, in the patch absorbed with rhodamine group, immunofluorescence showed rhodamine fluorescence in the neointima, inside the patch, and in the adventitia. There was a significantly thinner neointima in the plant patch absorbed with rapamycin (p = 0.0231) compared to the patch absorbed with distilled water. There was a significantly large number of IL-33 (p = 0.006) and IL-1β (p = 0.012) positive cells in the human SVG neointima compared to the human great saphenous vein. In rats, there was a significantly thinner neointima, a smaller number of IL-33 (p = 0.0006) and IL-1β (p = 0.0008) positive cells in the IL-33 antibody-absorbed patch group compared to the IL-33-absorbed patch group.Conclusion: We found that the natural absorption capability of plant leaves means they can absorb drug solution efficiently and can also be used as a novel drug delivery system and venous patch. IL-33 plays a role in venous neointimal hyperplasia both in humans and rats; neutralization of IL-33 by IL-33 antibody can be a therapeutic method to decrease venous neointimal hyperplasia.

show abstract

“…The degree of crystallization in the polymer will finally affect its degradation, cells adhesion as well as immune response. [ 36 ] Thus, the melting and crystallization behaviors of the electrospun P4HB‐based mats were investigated by DSC. The corresponding crystallization temperature ( T c ), melting temperature ( T m ), crystallization enthalpy (Δ H c ), and melting enthalpy (Δ H m ) of the samples are summarized in Table S1, Supporting Information.…”

Section: Resultsmentioning

confidence: 99%

Bioactive Poly(4‐hydroxybutyrate)/Poly(ethylene glycol) Fibrous Dressings Incorporated with Zinc Oxide Nanoparticles for Efficient Antibacterial Therapy and Rapid Clotting

Yuan

Sun

Shen

et al. 2022

Macromolecular Bioscience

View full text Add to dashboard Cite

Antibacterial and hemostatic properties are of great importance to wound dressing in treating trauma. Poly(4-hydroxybutyrate) (P4HB), an U.S. Food and Drug Administration (FDA)-approved bioabsorbable polyester, is used as dermal substitutes to prevent sever wound contraction and improve wound healing. However, P4HB fibrous mats are not efficient in halting bleeding and preventing bacterial associated infection. Here the authors prepare a new kind of wound dressing by incorporating poly(ethylene glycol) (PEG) and zinc oxide (ZnO) nanoparticles into the P4HB matrix by using electrospinning method. The in vitro results reveal that the P4HB/PEG/ZnO dressings can synergistically help blood clotting, prevent bacteria adhesion, and kill bacteria efficiently. It's found that the bactericidal activity of the bioactive P4HB/PEG/ZnO dressings is related to the release of Zn 2+ ions rather than reactive oxygen species (ROS) under dark condition. The in vivo antibacterial evaluation indicates that the bioactive P4HB/PEG/ZnO dressings can successfully prevent wound infections in Sprague-Dawley (SD) rats' skin defect model. The in vivo hemostatic experiments evaluated in the rabbit ear injury model further confirm that the bioactive P4HB/PEG/ZnO dressings have excellent hemostatic performance. Hence, this study demonstrates that the bioactive P4HB/PEG/ZnO dressings with hemostatic and bactericidal properties have great potential in possible clinical applications.

show abstract

What affects the biocompatibility of polymers?

Cited by 99 publications

References 171 publications

Stochastic Ultralow-Frequency Oscillations of the Luminescence Intensity from the Surface of a Polymer Membrane Swelling in Aqueous Salt Solutions

Stochastic Ultralow-Frequency Oscillations of the Luminescence Intensity from the Surface of a Polymer Membrane Swelling in Aqueous Salt Solutions

A Novel Plant Leaf Patch Absorbed With IL-33 Antibody Decreases Venous Neointimal hyperplasia

Bioactive Poly(4‐hydroxybutyrate)/Poly(ethylene glycol) Fibrous Dressings Incorporated with Zinc Oxide Nanoparticles for Efficient Antibacterial Therapy and Rapid Clotting

Contact Info

Product

Resources

About