What adverse health effects will environmental heavy metal co-exposure bring us: based on a biological monitoring study of sanitation workers

Li, Zhilin; Kuang, Hongxuan; Li, Leizi; Wu, Maorong; Liao, Zengquan; Zeng, Keqin; Ye, Yu-Feng; Fan, Ruifang

doi:10.1007/s11356-022-24805-9

Cited by 7 publications

(3 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 5 Chronic exposure to Cd( ii ), Cr( vi ), Ni( ii ), and Pb( ii ) in humans may cause kidney and bone damage, adverse respiratory effects, contact allergies, and neurotoxicity, respectively. 6 From 1972 to 2017, a discerning trend has emerged: a significant portion of the world's rivers and lakes have succumbed to contamination due to industrialization and urbanization, primarily attributed to the presence of 12 heavy metals (Al, As, Cd, Co, Cr, Cu, Fe, Hg, Mn, Ni, Pb, and Zn). 7 The HM concentrations in surface water exhibit pronounced disparities.…”

Section: Introductionmentioning

confidence: 99%

Cyanoremediation of heavy metals (As(v), Cd(ii), Cr(vi), Pb(ii)) by live cyanobacteria (Anabaena variabilis, and Synechocystis sp.): an eco-sustainable technology

Hossain,

Okino

2024

RSC Adv.

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Cyanoremediation of heavy metals (As(v), Cd(ii), Cr(vi), Pb(ii)) by live cyanobacteria (Anabaena variabilis, and Synechocystis sp.): an eco-sustainable technology

Hossain,

Okino

2024

RSC Adv.

View full text Add to dashboard Cite

show abstract

“…Long-term occupational exposure to molybdenum has been associated with an elevated incidence of cardiovascular disease [1]. Molybdenum toxicity can disrupt the absorption of copper and elevate uric acid levels, resulting in symptoms resembling gout, such as joint pain and swelling.…”

Section: Introductionmentioning

confidence: 99%

Blood molybdenum level as a marker of cancer risk among BRCA1 carriers

Matuszczak,

Kiljańczyk,

Marciniak

et al. 2024

Preprint

View full text Add to dashboard Cite

Purpose:A large proportion of ovarian and breast cancer cases are due to genetic predisposition. Women with a mutation in the BRCA1 gene have an up to an 80% chance of developing breast cancer and 40% chance of developing ovarian cancer. No studies to date assess exposure to molybdenum and cancer risk. The purpose of our study was to see if exposure to molybdenum modifies cancer risk in BRCA1 mutation carriers. Material and Methods: The study included 989 initially unaffected women with a BRCA1 mutation. The mean follow-up time was 6.8 years. During this time, 172 cancers occurred including 121 breast, 29 ovarian and 22 cancers at other sites. The cohort was stratified into three categories (tertiles) based on the blood level of molybdenum (<0.54 µg/L, 0.54-0.70 µg/L and >0.70 µg/L) with the lowest tertile forming the reference group. Cox proportional hazards models were used to model the association between blood molybdenum levels and cancer incidence. Results:A high blood molybdenum level (>0.70 µg/L) was associated with a significantly increased risk of developing ovarian cancer (HR = 5.55; 95%CI: 1.59-19.4; p = 0.007) and of any cancer (HR = 1.74; 95%CI: 1.17-2.61; p = 0.007) but not of breast cancer (HR = 1.46, CI= 0.91-2.33; p = 0.12). Conclusion:It is possible that lowering molybdenum levels may reduce the risk of cancer among women with a pathogenic germline variant in BRCA1.

show abstract

“…However, measurements of urine metals should be combined with clinical effect markers of target organs before drawing conclusions regarding the effects of metal AM. Metal exposure can effect various organs, such as kidney ( 24 ), liver ( 25 , 26 ), and the cardiovascular system ( 27 , 28 ). Functional status of these organs can be assessed using common clinical markers including liver markers aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), and alkaline phosphatase (ALP) in blood, as well as the urine marker of alpha-1-microglobulin (α-1-M) that could identify renal tubular damage ( 29 ).…”

Section: Introductionmentioning

confidence: 99%

Occupational exposure and health surveys at metal additive manufacturing facilities

Assenhöj,

Almstrand,

Kokelj

et al. 2023

Front. Public Health

View full text Add to dashboard Cite

IntroductionAdditive manufacturing is a novel state-of-the art technology with significant economic and practical advantages, including the ability to produce complex structures on demand while reducing the need of stocking materials and products. Additive manufacturing is a technology that is here to stay; however, new technologies bring new challenges, not only technical but also from an occupational health and safety perspective. Herein, leading Swedish companies using metal additive manufacturing were studied with the aim of investigating occupational exposure and the utility of chosen exposure- and clinical markers as predictors of potential exposure-related health risks.MethodsExposure levels were investigated by analysis of airborne dust and metals, alongside particle counting instruments measuring airborne particles in the range of 10 nm−10 μm to identify dusty work tasks. Health examinations were performed on a total of 48 additive manufacturing workers and 39 controls. All participants completed a questionnaire, underwent spirometry, and blood and urine sampling. A subset underwent further lung function tests.ResultsExposure to inhalable dust and metals were low, but particle counting instruments identified specific work tasks with high particle emissions. Examined health parameters were well within reference values on a group level. However, statistical analysis implied an impact on workers kidney function and possible airway inflammation.ConclusionThe methodology was successful for investigating exposure-related health risks in additive manufacturing. However, most participants have been working <5 years. Therefore, long-term studies are needed before we can conclusively accept or reject the observed effects on health.

show abstract

What adverse health effects will environmental heavy metal co-exposure bring us: based on a biological monitoring study of sanitation workers

Cited by 7 publications

References 55 publications

Cyanoremediation of heavy metals (As(v), Cd(ii), Cr(vi), Pb(ii)) by live cyanobacteria (Anabaena variabilis, and Synechocystis sp.): an eco-sustainable technology

Cyanoremediation of heavy metals (As(v), Cd(ii), Cr(vi), Pb(ii)) by live cyanobacteria (Anabaena variabilis, and Synechocystis sp.): an eco-sustainable technology

Blood molybdenum level as a marker of cancer risk among BRCA1 carriers

Occupational exposure and health surveys at metal additive manufacturing facilities

Contact Info

Product

Resources

About