What About the Role of Virtual Reality in Parkinson Disease’s Cognitive Rehabilitation? Preliminary Findings From a Randomized Clinical Trial

Maggio, Maria Grazia; Cola, Maria Cristina De; Latella, Dèsiréè; Maresca, Giuseppa; Finocchiaro, Chiara; Rosa, Gianluca La; Cimino, Vincenzo; Sorbera, Chiara; Bramantı, Placido; Luca, Rosaria De; Calabrò, Rocco Salvatore

doi:10.1177/0891988718807973

Cited by 88 publications

(76 citation statements)

References 32 publications

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“…Previous studies indicated VR-based training benefits on balance (Lee et al, 2015;Liao et al, 2015;Wang et al, 2019), executive, and visuospatial (Maggio et al, 2018) abilities of participants with PD. Nevertheless, the effects on gait velocity and distance are less evident (Wang et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Feasibility of a Short-Term Virtual Reality Balance Intervention to Improve Mobility Smoothness in Parkinson's Disease

Schuch

Balbinot

Bonilla

et al. 2020

Front. virtual real.

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Parkinson's disease (PD) is a neurodegenerative condition that is often associated with movement impairments, such as reduced balance and gait control. Virtual reality (VR) is a promising intervention for enhancing rehabilitation efficiency and may assist in overcoming functional limitations imposed by the disability. The objective of this study was to evaluate the feasibility, safety, and efficacy of a 5-weeks VR intervention in increasing mobility smoothness in participants with PD. Participants were assessed using functional mobility tasks-Timed Up and Go (TUG) and 10-m walking test (10MWT) and cognitive function tests. A total of 23 participants with a diagnosis of PD were randomly assigned to groups of VR or control interventions. In the VR group, for each session, participants received a VR-based balance training, i.e., tightrope simulator, for 20 min, preceded by 8 min of total body warm-up (total of 10 sessions over 5 weeks). Participants in the control group received 20 min of psychoeducation without a structured exercise program (twice a week). All screened participants engaged and completed a total of 10 VR-based intervention sessions. VR-based balance training caused no significant improvement in mobility smoothness for TUG or 10MWT (p > 0.05). Similarly, cognitive function was not affected by the VR intervention (p > 0.05). The outcomes of this study suggest that 10-20 min of VR-based intervention is a feasible and safe rehabilitation activity. However, it was insufficient to promote improvement in mobility smoothness and cognitive function in participants with PD. A combination of task-specific training in the virtual and physical environments in a more intensive approach is warranted for future study designs.

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Section: Discussionmentioning

confidence: 99%

Feasibility of a Short-Term Virtual Reality Balance Intervention to Improve Mobility Smoothness in Parkinson's Disease

Schuch

Balbinot

Bonilla

et al. 2020

Front. virtual real.

View full text Add to dashboard Cite

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“…Concerning the first point, our case-report, consistently with the literature data we reviewed here, suggests that VR could be a valuable methodology to support rehabilitation, as it allows obtaining positive functional motor and cognitive outcomes [ 13 , 14 , 48 , 56 ]. VR is the multisensory and interactive simulation of ecological scenarios, generally presented in a three-dimensional way, with which the patient can interact [ 15 , 58 , 59 , 60 , 61 ]. The VR devices use specific software with input-output peripherals that make the experience complex and engaging, promoting the improvement of the bodily functions of patients with motor/cognitive disabilities, as well as their well-being and participation [ 62 , 63 , 64 ].…”

Section: Discussionmentioning

confidence: 99%

Virtual Reality Based Cognitive Rehabilitation in Minimally Conscious State: A Case Report with EEG Findings and Systematic Literature Review

et al. 2020

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Chronic disorders of consciousness cause a total or partial and fluctuating unawareness of the surrounding environment. Virtual reality (VR) can be useful as a diagnostic and/or a neurorehabilitation tool, and its effects can be monitored by means of both clinical and electroencephalography (EEG) data recording of brain activity. We reported on the case of a 17-year-old patient with a disorder of consciousness (DoC) who was provided with VR training to improve her cognitive-behavioral outcomes, which were assessed using clinical scales (the Coma Recovery Scale-Revised, the Disability Rating Scale, and the Rancho Los Amigos Levels of Cognitive Functioning), as well as EEG recording, during VR training sessions. At the end of the training, significant improvements in both clinical and neurophysiological outcomes were achieved. Then, we carried out a systematic review of the literature to investigate the role of EEG and VR in the management of patients with DoC. A search on PubMed, Web of Science, Scopus, and Google Scholar databases was performed, using the keywords: “disorders of consciousness” and “virtual reality”, or “EEG”. The results of the literature review suggest that neurophysiological data in combination with VR could be useful in evaluating the reactions induced by different paradigms in DoC patients, helping in the differential diagnosis. In conclusion, the EEG plus VR approach used with our patient could be promising to define the most appropriate stimulation protocol, so as to promote a better personalization of the rehabilitation program. However, further clinical trials, as well as meta-analysis of the literature, are needed to be affirmative on the role of VR in patients with DoC.

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“…Patients exhibited significant improvements on the Montreal Cognitive Assessment (MoCA) and IADL after a 3-week VRbased cognitive and physical training: interestingly, after the VR intervention, functional near-infrared spectroscopy (NIRS) revealed decreased brain activation of the prefrontal areas as a result of increased neural efficiency during the training (53). Overall, several studies have highlighted the potential of VR in memory (54-57) and executive functions rehabilitation (58)(59)(60)(61). In particular, it has been shown that the multisensory stimulation has a positive impact on both the sense of presence and memory functioning (62).…”

Section: Virtual Reality In Rehabilitationmentioning

confidence: 99%

Virtual Reality Meets Non-invasive Brain Stimulation: Integrating Two Methods for Cognitive Rehabilitation of Mild Cognitive Impairment

et al. 2020

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Mild cognitive impairment (MCI) refers to a subtle, general cognitive decline with a detrimental impact on elderlies' independent living and quality of life. Without a timely diagnosis, this condition can evolve into dementia over time, hence the crucial need for early detection, prevention, and rehabilitation. For this purpose, current neuropsychological interventions have been integrated with (i) virtual reality, which immerses the user in a controlled, ecological, and safe environment (so far, both virtual reality-based cognitive and motor rehabilitation have revealed promising positive outcomes); and (ii) non-invasive brain stimulation, i.e., transcranial magnetic or electric brain stimulation, which has emerged as a promising cognitive treatment for MCI and Alzheimer's dementia. To date, these two methods have been employed separately; only a few studies (limited to motor rehabilitation) have suggested their integration. The present paper suggests to extend this integration to cognitive rehabilitation as well as to provide a multimodal stimulation that could enhance cognitive training, resulting in a more efficient rehabilitation.

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What About the Role of Virtual Reality in Parkinson Disease’s Cognitive Rehabilitation? Preliminary Findings From a Randomized Clinical Trial

Cited by 88 publications

References 32 publications

Feasibility of a Short-Term Virtual Reality Balance Intervention to Improve Mobility Smoothness in Parkinson's Disease

Feasibility of a Short-Term Virtual Reality Balance Intervention to Improve Mobility Smoothness in Parkinson's Disease

Virtual Reality Based Cognitive Rehabilitation in Minimally Conscious State: A Case Report with EEG Findings and Systematic Literature Review

Virtual Reality Meets Non-invasive Brain Stimulation: Integrating Two Methods for Cognitive Rehabilitation of Mild Cognitive Impairment

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