What About Gastric Schwannoma? A Review Article

Lauricella, Sara; Valeri, Sergio; Mascianà, Gianluca; Gallo, Ida Francesca; Mazzotta, Erica; Pagnoni, Chiara; Costanza, Saponaro; Falcone, Lorenza; Benvenuto, Domenico; Caricato, Marco; Capolupo, Gabriella Teresa

doi:10.1007/s12029-020-00456-2

Cited by 19 publications

(28 citation statements)

References 86 publications

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“…Although preoperative imaging cannot provide a definitive diagnosis, it can help determine the mass's location, origin, and size, which helps determine the surgical method and scope of mass resection. Extraluminal growth, central ulcer, and complex site of the lesion (gastric incision or small curvature of upper gastric body) are negative features of endoscopic treatment when the tumor is large (> 5 cm) [ 17 ]. When the previously mentioned mass properties were discovered, most experts believed that surgery should be performed.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological study of gastric schwannoma and review of related literature

Zhong

Liu

et al. 2022

BMC Surg

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Background This study aimed to investigate the clinical features, diagnostic criteria, treatment options, and prognosis of patients with gastric schwannoma (GS). Methods We collected the clinical data of all patients pathologically diagnosed with GS in Zhejiang Provincial People's Hospital from May 2012 to October 2021. Results A total of 26 cases of GS were analyzed clinicopathologically, where the sizes of the tumor were found to be in the range of 1–6 cm (mean: 3.16 cm, median: 3.05 cm). A computed tomography (CT) scan analysis revealed that most masses were either moderately progressive or uniformly enhanced. According to ultrasound gastroscopy results, most of them were hypoechoic masses. There were 23 cases of surgery and three cases of endoscopic submucosal tumor dissection. Immunohistochemistry demonstrated that S100 was positive in 26 patients, immunomarker SOX10 was positive in five, whereas CD34, CD117, and SMA were negative in most patients. CK (Pan), Dog-1, and Desmin were also found negative. All 26 cases were followed up after the conclusion of the study where no evidence of recurrence or metastasis was observed. Conclusions GS is a unique form of peripheral schwannoma. The diagnosis of this type of tumor depends on the pathology and immunohistochemistry of the individual. The key to treating this type of tumor is endoscopy and surgery. Follow up and related literature review showed that GS was a benign tumor with little possibility of malignant transformation.

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Section: Discussionmentioning

confidence: 99%

Clinicopathological study of gastric schwannoma and review of related literature

Zhong

Liu

et al. 2022

BMC Surg

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“…Minimally invasive "rendez-vous" surgery allows the opportunity to make an accurate histological analysis while a high level of patient comfort is maintained [19,20]. About three-quarters of GI tract schwannoma are located in the stomach, most commonly in the area of the great curvature, following with antrum and fundus [4,5,6,8]. Lauricella et al [8] found 686 patients with GS published in the English-language literature for over than 30 years.…”

Section: Disscusionmentioning

confidence: 99%

“…About three-quarters of GI tract schwannoma are located in the stomach, most commonly in the area of the great curvature, following with antrum and fundus [4,5,6,8]. Lauricella et al [8] found 686 patients with GS published in the English-language literature for over than 30 years. Most of the articles dealt with individual cases.…”

Section: Disscusionmentioning

confidence: 99%

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Combined laparoscopic-endoscopic “rendez-vous” procedure in a case of gastric schwannoma in a toddler

et al. 2022

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Introduction. Schwannomas are rare benign tumors of the gastrointestinal tract. Despite the differences in features of schwannomas located in the stomach as opposed to peripheral or soft tissue schwannomas, their immunohistochemical characteristics are the same. We present a case of a 14-month-old boy with a gastric tumor who underwent a combined laparoscopic-endoscopic resection surgery, followed by gastric schwannoma diagnosis. Case outline. The patient was admitted to our pediatric hospital with a fever of unknown origin. Endoscopy, performed after recurrent hematemesis, revealed an ulcer in the gastric antrum. At the four-week follow-up, gastroscopic and microscopic findings were normal. Two weeks later, a flank mass in the antrum was detected by an ultrasound examination. A new gastroscopy and CT scan confirmed the presence of a tumor-like mass, 5 cm in diameter. A combined laparoscopic-endoscopic polypectomy was performed with a necessary conversion for complete resection of tumor. The initial histological findings were consistent with a gastrointestinal stromal tumor. Due to this tumor?s rarity in childhood, the paraffin-embedded tissue samples were referred for a second opinion. Histological and immunohistochemical characteristics of the tumor made the gastrointestinal stromal tumor diagnosis unlikely and consistent with a completely resected gastric schwannoma. No recurrence of the disease occurred during the seven-year follow-up. Conclusion. Combined laparoscopic-endoscopic surgery is a feasible and effective treatment for large gastric tumors that cannot be excised endoscopically. Schwannoma should be included in the differential diagnostic consideration of gastric tumor lesions even in childhood.

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“…When symptomatic, depending on the location they can present as abdominal pain, bleeding, dyspepsia, obstruction, weight loss or nausea and vomiting 6 7 8 10 12 13 . Gastrointestinal schwannomas are mostly benign with very few cases of malignant transformation 13 14 15 16 . Historically, surgical resection has been the mainstay of therapy 8 15 .…”

Section: Introductionmentioning

confidence: 99%

Natural history of gastrointestinal schwannomas

et al. 2022

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Background and study aims Data are lacking on the natural history of gastrointestinal tract schwannomas. We aimed to study the natural history of all gastrointestinal schwannomas including location, diagnosis, management, and long-term outcomes. Patients and methods Patients with a pathological diagnosis of gastrointestinal schwannoma between January 2000 and March 2020 were identified. Data on baseline demographics, presentations, associated malignancies, malignant transformation, treatment, and recurrence were collected. Results Our cohort consisted of 44 patients with a mean age of 58.6 years, with 63.6 % women and 84.1 % White. The stomach (38.6 %) was the most common location followed by the colorectum (31.8 %). Only 22.7 % of patients were symptomatic and 22.0 % had a personal history of other malignancies. Tissue diagnosis was obtained via endoscopy in 47.7 % and from surgical pathology in 52.3 %. On histology, 65.9 % of the tumors were solid, 11.4 % had mixed features, and 2.3 % had necrosis. SP100 was tested in all but one patient and was positive in all. Mean Ki-67 in 12 patients with tumors measuring ≥ 2 cm was 3.0 % indicating a low proliferation rate. Of the patients, 77.3 % had surgery and 18.2 % underwent endoscopic resection. At a mean follow-up of 5.0 ± 4.31 years, there was no malignant transformation, recurrence or mortality associated with gastrointestinal schwannomas. Conclusions Gastrointestinal schwannomas are diagnosed in the fifth to sixth decade with predominance in women and Whites. They are benign, mostly asymptomatic, and diagnosed incidentally. Asymptomatic gastrointestinal schwannomas including lesions ≥ 2 cm in size do not appear to need further monitoring or intervention. Patients with them should be counseled to remain up to date with routine screening guidelines pertaining to the colon, breast, and lung cancer due to the high incidence of concomitant malignancy.

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What About Gastric Schwannoma? A Review Article

Cited by 19 publications

References 86 publications

Clinicopathological study of gastric schwannoma and review of related literature

Clinicopathological study of gastric schwannoma and review of related literature

Combined laparoscopic-endoscopic “rendez-vous” procedure in a case of gastric schwannoma in a toddler

Natural history of gastrointestinal schwannomas

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