Wharton’s jelly mesenchymal stromal cells inhibit T-cell proliferation by synergistic IDO and mitochondrial transfer mechanisms
Cécile Pochon,
Romain Perouf,
Allan Bertrand
et al.
Abstract:Background Wharton's jelly mesenchymal stem cells (WJ-MSCs) are multipotent stromal cells derived from the umbilical cord that may have therapeutic potential in immune-related diseases. In the context of allogeneic stem cell transplantation, WJ-MSCs represent a good candidate for graft versus host disease (GVHD) prophylaxis and treatment.Methods Herein, we investigated the immunomodulatory mechanisms of WJ-MSCs, produced at clinical grade according to our Good Manufacturing Practice, in vitro and in an experim… Show more
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