Wetting of planar solid surfaces by bicontinuous sugar surfactant-based microemulsions

Vargas-Ruiz, Salomé; Lutzki, Jana; Klitzing, Regine von; Hellweg, Thomas; Wellert, Stefan

doi:10.1007/s00396-017-4188-4

Cited by 6 publications

(4 citation statements)

References 49 publications

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“…Subsequently, the study of contact angle-CA at the contact with planar surfaces constitutes a method to evaluate the wettability of a system, particularly hydrophilicity or hydrophobicity nature, as it was reported in the study of Popa L. et al [85]. Goniometry was rarely applied in the research of microemulsions, and it was considered that their behavior at the contact with surfaces is not fully unveiled [100]. Although, Butt U. et al studied some topical microemulsions for ophthalmic delivery which were characterized as hydrophilic systems after the evaluation of contact angle.…”

Section: Discussionmentioning

confidence: 99%

Insights from a Box–Behnken Optimization Study of Microemulsions with Salicylic Acid for Acne Therapy

et al. 2022

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The present study brings to attention a method to develop salicylic acid-based oil in water (O/W) microemulsions using a tensioactive system based on Tween 80, lecithin, and propylene glycol (PG), enriched with a vegetable oat oil phase and hyaluronic acid. The systems were physically characterized and the Quality by design approach was applied to optimize the attributes of microemulsions using Box–Behnken modeling, combined with response surface methodology. For this purpose, a 33 fractional factorial design was selected. The effect of independent variables namely X1: Tween 80/PG (%), X2: Lecithin (%), X3: Oil phase (%) was analyzed considering their impact upon the internal structure and evaluated parameters chosen as dependent factors: viscosity, mean droplet size, and work of adhesion. A high viscosity, a low droplet size, an adequate wettability—with a reduced mechanical work—and clarity were considered as desirable for the optimal systems. It was found that the optimal microemulsion which complied with the established conditions was based on: Tween 80/PG 40%, lecithin 0.3%, oat oil 2%, salicylic acid 0.5%, hyaluronic acid 1%, and water 56.2%. The response surface methodology was considered an appropriate tool to explain the impact of formulation factors on the physical properties of microemulsions, offering a complex pattern in the assessment of stability and quality attributes for the optimized formulation.

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Section: Discussionmentioning

confidence: 99%

Insights from a Box–Behnken Optimization Study of Microemulsions with Salicylic Acid for Acne Therapy

et al. 2022

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“…Various cationic surfactants derived from sugar groups exhibit advantages, including green characteristics, natural and renewable raw materials, facile biodegradability, and multifunctionality; these surfactants are also safe and mild for human body. Therefore, these surfactants have globally attracted considerable research attention [ 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Aggregation Behavior and Application Properties of Novel Glycosylamide Quaternary Ammonium Salts in Aqueous Solution

Wang,

Chen,

Zhang

et al. 2024

Molecules

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Amidation of lactobionic acid with N,N-dimethylaminopropyltriamine was conducted to obtain N-(3′-dimethylaminopropyl)-lactamido-3-aminopropane (DDLPD), which was quaternized with bromoalkanes of different carbon chain lengths to synthesize double-stranded lactosylamide quaternary ammonium salt N-[N′[3-(lactosylamide)]propyl-N′-alkyl] propyl-N,N-dimethyl-N-alkylammonium bromide (CnDDLPB, n = 8, 10, 12, 14, 16). The surface activity and the adsorption and aggregation behaviors of the surfactants were investigated via equilibrium surface tension, dynamic light scattering, and cryo-electron microscopy measurements in an aqueous solution. The application properties of the products in terms of wettability, emulsification, foam properties, antistatic, salt resistance, and bacteriostatic properties were tested. CnDDLPB exhibited a low equilibrium surface tension of 27.82 mN/m. With an increase in the carbon chain length, the critical micellar concentration of CnDDLPBD decreased. Cryo-electron microscopy revealed that all products except C8DDLPB formed stable monolayer, multi-layer, and multi-compartmental vesicle structures in an aqueous solution. C14DDLPB has the best emulsification performance on soybean oil, with a time of 16.6 min; C14DDLPB has good wetting and spreading properties on polytetrafluoroethylene (PTFE) when the length of carbon chain is from 8 to 14, and the contact angle can be lowered to 33°~40°; CnDDLPB has low foam, which is typical of low-foaming products; C8DDLPB and C10DDLPB both show good antistatic properties. C8DDLPB and C14DDLPB have good salt resistance, and C12DDLPB has the best antimicrobial property, with the inhibition rate of 99.29% and 95.28% for E. coli and Gluconococcus aureus, respectively, at a concentration of 350 ppm.

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“…Compared with traditional surfactants, sugar-based surfactants exhibit low toxicity, low irritant action, and good biocompatibility, because carbohydrates are “green” products with good biodegradability, a low environmental impact, and are made from renewable raw materials. Therefore, the research and development of sugar-based surfactants has gradually become a hot spot in the industry [ 9 , 10 ]. Adding sugar groups into the molecular structure of quaternary ammonium salt surfactants may improve their potential for irritation, toxicity, biodegradability, water solubility, compatibility and so on.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Performance of Double-Chain Quaternary Ammonium Salt Glucosamide Surfactants

et al. 2022

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A series of double-chain quaternary ammonium salt surfactants N-[N′[3-(gluconamide)] propyl-N′-alkyl]propyl-N, N-dimethyl-N-alkyl ammonium bromide (CnDDGPB, where n represents a hydrocarbon chain length of 8, 10, 12, 14 and 16) were successfully synthesized from D (+)-glucose δ-lactone, N, N-dimethyldipropylenetriamine, and bromoalkane using a two-step method consisting of a proamine-ester reaction and postquaternization. Their surface activity, adsorption, and aggregation behavior in aqueous solution were investigated via measurements of dynamic/static surface tension, contact angle, dynamic light scattering, and transmission electron microscopy. An analysis of their application performance in terms of wettability, emulsifying properties, toxicity, and antibacterial properties was conducted. The results show that with increasing the carbon chain length of the CnDDGPB surfactants, their critical micelle concentration (CMC) increased and the pC20 and efficiency in the interface adsorption of the target product gradually decreased. Moreover, the influence of the hydrophobic carbon chain length on the surface of polytetrafluoroethylene (PTFE) was even greater for the wetting effect, reducing the contact angle to 32° within the length range of C8–C14. The results of the contact angle change and the wettability experiments proved that C10DDGPB exhibited the best wettability. The liquid paraffin and soybean oil emulsification ability of CnDDGPB showed an upward trend followed by a downward trend with the growth of the carbon chain, with C12DDGPB exhibiting the best emulsification performance. The Dlong/Dshort ratio was far lower than 1, which indicates mixed-kinetic adsorption. The surfactants formed spherical micelles and showed a unique aggregation behavior in aqueous solution, which showed an increase–decrease–increase trend with the change in concentration. A cell toxicity and acute oral toxicity experiment showed that the CnDDGPB surfactants were less toxic than the commonly used surfactant dodecyldimethylbenzyl ammonium chloride (1227). In addition, at a concentration of 150 ppm, CnDDGPB exhibited the same bacteriostatic effect as 1227 at a concentration of 100 ppm. The results demonstrate that sugar-based amide cationic surfactants are promising as environmentally friendly disinfection products.

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Wetting of planar solid surfaces by bicontinuous sugar surfactant-based microemulsions

Cited by 6 publications

References 49 publications

Insights from a Box–Behnken Optimization Study of Microemulsions with Salicylic Acid for Acne Therapy

Insights from a Box–Behnken Optimization Study of Microemulsions with Salicylic Acid for Acne Therapy

Aggregation Behavior and Application Properties of Novel Glycosylamide Quaternary Ammonium Salts in Aqueous Solution

Synthesis and Performance of Double-Chain Quaternary Ammonium Salt Glucosamide Surfactants

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