Wettability gradient-induced alignment of peptide nanotubes as templates for biosensing applications

Almohammed, Sawsan; Oladapo, Sarah O.; Ryan, Kate; Kholkin, A. L.; Rice, James H.; Rodriguez, Brian J.

doi:10.1039/c6ra05732b

Cited by 37 publications

(79 citation statements)

References 42 publications

(77 reference statements)

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“…SEM images of the template (Figure c) reveal a similar degree of alignment as reported previously . SEM images further show spherical features that are assigned to Ag NP clusters.…”

Section: Resultssupporting

confidence: 81%

“…The process to form aligned FF‐PNT/Ag NP follows a previously reported method . Briefly, patterned regions are created by growing a silicon oxide layer on a Si surface via ultraviolet or ozone exposure through a 0.5‐cm mask opening (Figure a).…”

Section: Resultsmentioning

confidence: 99%

“…Deionized water was used to rinse the substrates, which were then blown dry using nitrogen. The patterned substrate was prepared as reported by Almohammed et al using a mask with an opening of 0.5 cm.…”

Section: Methodsmentioning

confidence: 99%

“…Nanocomposites based on plasmon‐active NPs and templating materials offer opportunities to achieve controlled NP localization and enhance the potential for improved SERS signal reproducibility, stability, and sensitivity . FF‐PNT‐based templating might provide effective control of nanostructure aggregation and NP distribution, resulting in more electromagnetic hot spots and enhanced SERS signals . Detailed studies using FF‐PNTs as a template for plasmon‐active NPs to detect various analyte concentrations by SERS have yet to be conducted.…”

Section: Introductionmentioning

confidence: 99%

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Aligned diphenylalanine nanotube–silver nanoparticle templates for high‐sensitivity surface‐enhanced Raman scattering

Almohammed

Fedele

Rodriguez

et al. 2017

J Raman Spectroscopy

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Self‐assembly offers potential routes for large‐scale, rapid, and cost‐effective surface‐enhanced Raman scattering (SERS) substrate designs. Here, a highly sensitive SERS template is reported, which utilizes aligned diphenylalanine nanotubes to form a dense packing arrangement of plasmon‐active silver nanoparticles. The template is stable under high laser illumination with a power density of ~6.25 MW/cm2 in comparison to only silver nanoparticles and enables picomolar and femtomolar probe molecule concentrations to be probed, indicative of single‐molecule SERS detection.

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“…SEM images of the template (Figure c) reveal a similar degree of alignment as reported previously . SEM images further show spherical features that are assigned to Ag NP clusters.…”

Section: Resultssupporting

confidence: 81%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Aligned diphenylalanine nanotube–silver nanoparticle templates for high‐sensitivity surface‐enhanced Raman scattering

Almohammed

Fedele

Rodriguez

et al. 2017

J Raman Spectroscopy

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“…One of the most studied representative building blocks, able to self‐assemble in supramolecular nanostructures (NSs), is the diphenylalanine homodimer (FF) . FF self‐assembles in nanotubes that show noteworthy mechanical rigidity along with a multiplicity of other chemical and physical functionalities, making it promising for potential application in nanomedicine, nanofabrication, tissue engineering, bio‐imaging, drug delivery, and fabrication of biosensors . However, the low water solubility of these peptide NSs has partially limited their application in nanomedicine.…”

Section: Introductionmentioning

confidence: 99%

Photoluminescent Peptide‐Based Nanostructures as FRET Donor for Fluorophore Dye

Diaferia

Sibillano

Giannini

et al. 2017

Chemistry A European J

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A great interest has been recently generated by the discovery that peptide-based nanostructures (NSs) endowed with cross-β structure may show interesting photoluminescent (PL) properties. It was shown that NSs formed by PEGylated hexaphenylalanine (PEG -F6, PEG=polyethylene glycol) are able to emit at 460 nm when excited at 370 or 410 nm. Here, the possibility to transfer the fluorescence of these PEG -F6-based NSs by foster resonance electron transfer (FRET) phenomenon to a fluorescent dye was explored. To achieve this aim, the 4-chloro-7-nitrobenzofurazan (NBD) dye was encapsulated in these NSs. Structural data in solution and in solid state, obtained by a variety of techniques (circular dichroism, Fourier-transform infrared spectroscopy, wide-angle X-ray scattering, and small-angle X-ray scattering), indicated that the organization of the peptide spine of PEG -F6 NS, which consists of anti-parallel β-sheets separated by a dry interface made of interacting phenylalanine side chains, was maintained upon NBD encapsulation. The spectroscopic characterization of these NSs clearly showed a red-shift of the emission fluorescence peak both in solution and in solid state. This shift from 460 to 530 nm indicated that a FRET phenomenon from the peptide-based to the fluorophore-encapsulated NS occurred. FRET could also be detected in the PEG -F6 conjugate, in which the NBD was covalently bound to the amine of the compound. On the basis of these results, it is suggested that the red-shift of the intrinsic PL of NSs may be exploited in the bio-imaging field.

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Biodegradable Piezoelectric Polymers: Recent Advancements in Materials and Applications

Mohsin

Bathaei

Istif

et al. 2023

Adv Healthcare Materials

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Recent materials, microfabrication, and biotechnology improvements have introduced numerous exciting bioelectronic devices based on piezoelectric materials. There is an intriguing evolution from conventional unrecyclable materials to biodegradable, green, and biocompatible functional materials. As a fundamental electromechanical coupling material in numerous applications, novel piezoelectric materials with a feature of degradability and desired electrical and mechanical properties are being developed for future wearable and implantable bioelectronics. These bioelectronics can be easily integrated with biological systems for applications, including sensing physiological signals, diagnosing medical problems, opening the blood‐brain barrier, and stimulating healing or tissue growth. Therefore, the generation of piezoelectricity from natural and synthetic bioresorbable polymers has drawn great attention in the research field. Herein, the significant and recent advancements in biodegradable piezoelectric materials, including natural and synthetic polymers, their principles, advanced applications, and challenges for medical uses, are reviewed thoroughly. The degradation methods of these piezoelectric materials through in vitro and in vivo studies are also investigated. These improvements in biodegradable piezoelectric materials and microsystems could enable new applications in the biomedical field. In the end, potential research opportunities regarding the practical applications are pointed out that might be significant for new materials research.

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Wettability gradient-induced alignment of peptide nanotubes as templates for biosensing applications

Abstract: Peptide nanotubes coated with silver nanoparticles and aligned using wettability-patterned substrates provide improved Raman intensity for biosensing applications.

Cited by 37 publications

References 42 publications

Aligned diphenylalanine nanotube–silver nanoparticle templates for high‐sensitivity surface‐enhanced Raman scattering

Aligned diphenylalanine nanotube–silver nanoparticle templates for high‐sensitivity surface‐enhanced Raman scattering

Photoluminescent Peptide‐Based Nanostructures as FRET Donor for Fluorophore Dye

Biodegradable Piezoelectric Polymers: Recent Advancements in Materials and Applications

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