Wettability and biocompatibility of nitrogen-doped hydrogenated amorphous carbon films: Effect of nitrogen

Yang, Ping; Huang, Nan; Leng, Yong Xiang; Yao, Zhigang; Zhou, Hong Fang; Maitz, Manfred F.; Leng, Yang; Chu, Paul K.

doi:10.1016/j.nimb.2005.08.081

Cited by 70 publications

(45 citation statements)

References 10 publications

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“…[26,31] The properties of a-C and DLC coatings, especially the biofunctional ones, can further be modified by incorporating other elements in the coatings, such as H, N, F, P, Si and metals. [4,5,[33][34][35][36][37][38][39] It is well known that the incorporation of additional elements into an amorphous carbon matrix has a very strong impact on the surface energy and wettability of such coatings. [40][41][42] Combining various surface modification methods should thus offer new tools for a future engineering design of biofunctional thin film materials, covering a wide range of properties, for example from strongly hydrophilic to extremely hydrophobic.…”

mentioning

confidence: 99%

Surface Topography, Surface Energy and Wettability of Magnetron‐Sputtered Amorphous Carbon (a‐C) Films and Their Relevance for Platelet Adhesion

Stüber¹,

Niederberger²,

Danneil³

et al. 2007

Adv Eng Mater

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Diamond-like carbon (DLC) and amorphous carbon (a-C, a-C:H) coatings, respectively, have been proposed since many years as potential materials for biomedical applications due to their chemical inertness, low friction coefficient, high wear resistance, bio-and haemocompatibility. [1][2][3][4][5][6] The feasibility of amorphous carbon coatings was investigated for a variety of applications like surgical needles, [2] orthopaedic implants and prostheses, [7][8][9][10][11] medical guidewires, [12][13][14][15] coronary artery stents [16,17] and also for mechanical heart valve replacement and other solid implants. [18][19][20][21][22][23] The functionality, performance and durability of artificial surfaces in vivo are determined and often limited by their interaction with blood or tissue. However, the coagulation mechanism of blood on amorphous carbon (DLC) films in such a biomedical environment is not understood in detail even if the biocompatibility of DLC coatings was described early by many reports. [1,3,[24][25][26] Extensive information on individual aspects, like protein adsorption, platelet adhesion and activation on carbonaceous surfaces has been accumulated in the literature. [27][28][29] Since a few years more sophisticated approaches to the scientific understanding of the complex interaction of blood and inorganic surfaces are emerging by addressing this field through fundamental and interdisciplinary research efforts offering synoptical views based on materials science, chemistry, biology, physics, physical chemistry and medicine. [30][31][32] Main factors have been recognised to influence significantly the cell adhesion and interaction on amorphous carbon: these include the constitution of the carbon films and the fraction of the sp 3 bonds, [12,30] the surface energy and hydrophobicity, [27] and the surface roughness and topography. [26,31] The properties of a-C and DLC coatings, especially the biofunctional ones, can further be modified by incorporating other elements in the coatings, such as H, N, F, P, Si and metals. [4,5,[33][34][35][36][37][38][39] It is well known that the incorporation of additional elements into an amorphous carbon matrix has a very strong impact on the surface energy and wettability of such coatings. [40][41][42] Combining various surface modification methods should thus offer new tools for a future engineering design of biofunctional thin film materials, covering a wide range of properties, for example from strongly hydrophilic to extremely hydrophobic. Recently, it was shown that the modification of the inherent surface topography of carbon films on the nano-scale by proper adjusting of the deposition process and kinetics can strongly impact the wetting behaviour. [43] Similar or complementary effects were achieved through creating an artificial micro-or nano-scale surface topography by laser-patterning or plasma-etching or by subsequent thermal processing of carbon coatings. [44][45][46] From the biological perspective, the competitive adsorption of several plasma proteins (al...

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mentioning

confidence: 99%

Surface Topography, Surface Energy and Wettability of Magnetron‐Sputtered Amorphous Carbon (a‐C) Films and Their Relevance for Platelet Adhesion

Stüber¹,

Niederberger²,

Danneil³

et al. 2007

Adv Eng Mater

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“…22) Nitrogen-incorporated a-C:H (a-C:H:N) is also reported as well biocompatible thin films with ECs. 23,24) In our present study, we have focused on the effects of fluorine incorporation upon HUVEC adhesion and proliferation. We assessed the viability of HUVECs by measuring the enzymatic activity using a Cell Counting Kit-8 (WST-8 assay kit).…”

Section: )mentioning

confidence: 99%

Human Umbilical Vein Endothelial Cell Interaction with Fluorine-Incorporated Amorphous Carbon Films

Yoshimoto

Hasebe

Nagashima

et al. 2012

Jpn. J. Appl. Phys.

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A major clinical concern in coronary intervention for cardiovascular disease is late stent thrombosis after the implantation of drug eluting stents (DES). DES widely used in clinical settings currently utilize polymer coatings, which can induce persistent arterial wall inflammation and delayed vascular healing, resulting in impaired endothelialization. We examined the viability of human umbilical vein endothelial cells (HUVECs) for fluorine-incorporated amorphous carbon (a-C:H:F) coatings, which are known to be anti-thrombogenic. a-C:H:F and a-C:H were synthesized on the tissue culture dishes using radio frequency plasma enhanced chemical vapor deposition by varying the ratio of hexafluoroethane and acetylene. HUVECs were seeded on coated dishes for 6 days. The results indicate that the a-C:H:F surface does not disturb HUVEC proliferation in 6 days of culture and is promising for stent materials that allows the preservation of endothelialization, even if the fluorine concentration of a-C:H surface affects the early adhesion of endothelial cells.

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“…The properties of DLC films can be tuned by the addition of other elements [3]. Added nitrogen causes increased film hydrophilicity and roughness [4] and thus better cell adhesion and biocompatibility [4,5]. The hardness of the film decreases with the addition of nitrogen [6], and the optical properties of the film [7,8] as well as the electrical properties [7,9] are changed.…”

Section: Introductionmentioning

confidence: 99%

Modification of diamond-like carbon films by nitrogen incorporation via plasma immersion ion implantation

Flege

Hatada

Hoefling

et al. 2015

Nuclear Instruments and Methods in Physics Research Section B:

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Wettability and biocompatibility of nitrogen-doped hydrogenated amorphous carbon films: Effect of nitrogen

Cited by 70 publications

References 10 publications

Surface Topography, Surface Energy and Wettability of Magnetron‐Sputtered Amorphous Carbon (a‐C) Films and Their Relevance for Platelet Adhesion

Surface Topography, Surface Energy and Wettability of Magnetron‐Sputtered Amorphous Carbon (a‐C) Films and Their Relevance for Platelet Adhesion

Human Umbilical Vein Endothelial Cell Interaction with Fluorine-Incorporated Amorphous Carbon Films

Modification of diamond-like carbon films by nitrogen incorporation via plasma immersion ion implantation

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