Wet microcontact printing (µCP) for micro-reservoir drug delivery systems

Lee, Hong Pyo; Ryu, WonHyoung

doi:10.1088/1758-5082/5/2/025011

Cited by 9 publications

(6 citation statements)

References 32 publications

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“…A modified version of MIMIC is currently being studied to load drugs into microdevice reservoirs. Lee et al loaded small amounts of model drugs methylene blue and tetracycline hydrochloride into microreservoirs using wet microcontact printing method [131]. In this process, a liquid drug-carrier solvent mixture was transferred to the reservoir by contact printing process as shown in Figure 4 E.…”

Section: Loading Of Novel Micro- and Nanoscale Oral Drug Delivery mentioning

confidence: 99%

Micro/nanofabricated platforms for oral drug delivery

Fox

Kim

et al. 2015

Journal of Controlled Release

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The oral route of drug administration is most preferred due to its ease of use, low cost, and high patient compliance. However, the oral uptake of many small molecule drugs and biotherapeutics is limited by various physiological barriers, and, as a result, drugs suffer from issues with low solubility, low permeability, and degradation following oral administration. The flexibility of micro- and nanofabrication techniques has been used to create drug delivery platforms designed to address these barriers to oral drug uptake. Specifically, micro/nanofabricated devices have been designed with planar, asymmetric geometries to promote device adhesion and unidirectional drug release toward epithelial tissue, thereby prolonging drug exposure and increasing drug permeation. Furthermore, surface functionalization, nanotopography, responsive drug release, motion-based responses, and permeation enhancers have been incorporated into such platforms to further enhance drug uptake. This review will outline the application of micro/nanotechnology to specifically address the physiological barriers to oral drug delivery and highlight technologies that may be incorporated into these oral drug delivery systems to further enhance drug uptake.

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Section: Loading Of Novel Micro- and Nanoscale Oral Drug Delivery mentioning

confidence: 99%

Micro/nanofabricated platforms for oral drug delivery

Fox

Kim

et al. 2015

Journal of Controlled Release

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“…Micro-reservoir systems consisting of one or more drug reservoirs are utilized for temporary storage of drugs and have been applied to provide well-controlled platforms for carrier-free drugs loading and delivery at the microscale [38, 39]. Micro-reservoir systems which are fabricated via the microfabrication technology provide more precise control over drug delivery rates and allow physicians to actively start, modify, and stop drug release at desired locations in an interactive format [40].…”

Section: Drug Carrier-free Microfluidic Systems For Controlled Drumentioning

confidence: 99%

Recent advances of controlled drug delivery using microfluidic platforms

Sanjay

Zhou

Dou

et al. 2018

Advanced Drug Delivery Reviews

279

163

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Conventional systematically-administered drugs distribute evenly throughout the body, get degraded and excreted rapidly while crossing many biological barriers, leaving minimum amounts of the drugs at pathological sites. Controlled drug delivery aims to deliver drugs to the target sites at desired rates and time, thus enhancing the drug efficacy, pharmacokinetics, and bioavailability while maintaining minimal side effects. Due to a number of unique advantages of the recent microfluidic lab-on-a-chip technology, microfluidic lab-on-a-chip has provided unprecedented opportunities for controlled drug delivery. Drugs can be efficiently delivered to the target sites at desired rates in a well-controlled manner by microfluidic platforms via integration, implantation, localization, automation, and precise control of various microdevice parameters. These features accordingly make reproducible, on-demand, and tunable drug delivery become feasible. On-demand self-tuning dynamic drug delivery systems have shown great potential for personalized drug delivery. This review presents an overview of recent advances in controlled drug delivery using microfluidic platforms. The review first briefly introduces microfabrication techniques of microfluidic platforms, followed by detailed descriptions of numerous microfluidic drug delivery systems that have significantly advanced the field of controlled drug delivery. Those microfluidic systems can be separated into four major categories, namely drug carrier-free micro-reservoir-based drug delivery systems, highly integrated carrier-free microfluidic lab-on-a-chip systems, drug carrier-integrated microfluidic systems, and microneedles. Microneedles can be further categorized into five different types, i.e. solid, porous, hollow, coated, and biodegradable microneedles, for controlled transdermal drug delivery. At the end, we discuss current limitations and future prospects of microfluidic platforms for controlled drug delivery.

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“…The design of the outlet is one of the key factors that determine the drug release rate. Control of the drug release rate can be obtained through variation in the dimensions of the outlet channel [24,25]. Various rates of drug delivery can be achieved by combining the existing passive methods.…”

Section: Characteristics Of the Devicementioning

confidence: 99%

A wireless actuating drug delivery system

Baek

Park

2015

J. Micromech. Microeng.

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A wireless actuating drug delivery system was devised. The system is based on induction heating for drug delivery. In this study, thermally generated nitrogen gas produced by induction heating of azobisisobutyronitrile (AIBN) was utilized for pressure-driven release of the drug. The delivery device consists of an actuator chamber, a drug reservoir, and a microchannel. A semicircular copper disc (5 and 6 mm in diameter and 100 µm thick), and thermal conductive tape were integrated as the heating element in the actuator chamber. The final device was 2.7 mm thick. 28 µl of drug solution were placed in the reservoir and the device released the drug quickly at the rate of 6 µl s−1 by induction heating at 160 µT of magnetic intensity. The entire drug solution was released and dispersed after subcutaneous implantation under identical experimental condition. This study demonstrates that the device was simply prepared and drug delivery could be achieved by wireless actuation of a thin, pressure-driven actuator.

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Wet microcontact printing (µCP) for micro-reservoir drug delivery systems

Cited by 9 publications

References 32 publications

Micro/nanofabricated platforms for oral drug delivery

Micro/nanofabricated platforms for oral drug delivery

Recent advances of controlled drug delivery using microfluidic platforms

A wireless actuating drug delivery system

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