1999
DOI: 10.1002/(sici)1099-1263(199907/08)19:4<285::aid-jat580>3.0.co;2-x
|View full text |Cite
|
Sign up to set email alerts
|

Wet decontamination-induced stratum corneum hydration—effects on the skin barrier function to diethylmalonate

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

2
23
0

Year Published

2010
2010
2021
2021

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 31 publications
(25 citation statements)
references
References 7 publications
2
23
0
Order By: Relevance
“…Detergents are also currently considered as skin permeation enhancers of other agents, including drugs, pollutants and toxic compounds [5,9,10,11]. The enhancing effect is probably due to a deleterious impact of detergents on the natural skin barrier which means skin delipidation, irritation and membrane fluidization [5,12,13] and/or increasing of skin hydration [5] which leads to higher permeation rates [4].…”
Section: Resultsmentioning
confidence: 99%
“…Detergents are also currently considered as skin permeation enhancers of other agents, including drugs, pollutants and toxic compounds [5,9,10,11]. The enhancing effect is probably due to a deleterious impact of detergents on the natural skin barrier which means skin delipidation, irritation and membrane fluidization [5,12,13] and/or increasing of skin hydration [5] which leads to higher permeation rates [4].…”
Section: Resultsmentioning
confidence: 99%
“…However, there is also a risk that dermal absorption of diethyl malonate may be significantly increased during decontamination procedures. Loke, U, Lau, et al () suggested that the enhancement effect was attributed to either the spreading of the chemical over the skin during washing, or the transient skin hydration during washing, leading to a decrease in skin barrier properties. However, as diethyl malonate is metabolized into a relatively non‐hazardous compound (malonic acid) (Opdyke, ), the simulant itself has a relatively low dermal toxicity.…”
Section: Discussionmentioning
confidence: 99%
“…In vitro Qualitative determination of the effect of wet decontamination on skin hydration, and subsequent issues with decontamination of CWA simulant diethylmalonate. Loke et al, 1999 Simulation of soman decontamination using diethyl malonate and a showering method. Reifenrath, Mershon, Brinkley, et al, 1984 In silico Use of cheminformatics to determine suitable CWA simulant choice.…”
Section: Ribordy Et Al 2012mentioning
confidence: 99%
“…The lowest decontamination effectiveness was achieved against paraoxon (PR=1.6 to 2.6), followed by soman (PR=2.6 to 3.6). A more effective decontamination was achieved against VX (PR=10.0 to 64.8) which penetrated tissue slowly (15) (14,19,20). Although the chemical composition of the tested detergents was similar, the highest decontamination effectiveness against all of the tested OPs was consistently achieved with Argos TM , which was also the most effective in the decontamination of sulphur mustard (9).…”
Section: Decontamination Of Opmentioning
confidence: 99%