Wet beriberi with multiple organ failure remarkably reversed by thiamine administration

Lei, Y.; Zheng, Ming‐Hua; Huang, Weijian; Zhang, Jie; Lu, Yingru

doi:10.1097/md.0000000000010010

Cited by 38 publications

(35 citation statements)

References 31 publications

(70 reference statements)

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“…Supplementation, on the other hand, does not have as profound an effect in people who are nutrient replete. For example, administration of thiamin in wet Beri-Beri can be curative and life-saving [ 24 ], whereas supplementation in patients with normal thiamin levels would not be so dramatic. Likewise, studies such as VITAL have shown the most CVD benefit in patients with the lowest baseline levels of Ω-3 [ 16 ], who may represent the ideal population for this therapy.…”

Section: The Critical Importance Of Dosagementioning

confidence: 99%

An Update on Omega-3 Polyunsaturated Fatty Acids and Cardiovascular Health

Elagizi¹,

Lavie²,

O’Keefe

et al. 2021

Nutrients

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Interest in the potential cardiovascular (CV) benefits of omega-3 polyunsaturated fatty acids (Ω-3) began in the 1940s and was amplified by a subsequent landmark trial showing reduced CV disease (CVD) risk following acute myocardial infarction. Since that time, however, much controversy has circulated due to discordant results among several studies and even meta-analyses. Then, in 2018, three more large, randomized trials were released—these too with discordant findings regarding the overall benefits of Ω-3 therapy. Interestingly, the trial that used a higher dose (4 g/day highly purified eicosapentaenoic acid (EPA)) found a remarkable, statistically significant reduction in CVD events. It was proposed that insufficient Ω-3 dosing (<1 g/day EPA and docosahexaenoic acid (DHA)), as well as patients aggressively treated with multiple other effective medical therapies, may explain the conflicting results of Ω-3 therapy in controlled trials. We have thus reviewed the current evidence regarding Ω-3 and CV health, put forth potential reasoning for discrepant results in the literature, highlighted critical concepts such as measuring blood levels of Ω-3 with a dedicated Ω-3 index and addressed current recommendations as suggested by health care professional societies and recent significant scientific data.

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Section: The Critical Importance Of Dosagementioning

confidence: 99%

An Update on Omega-3 Polyunsaturated Fatty Acids and Cardiovascular Health

Elagizi¹,

Lavie²,

O’Keefe

et al. 2021

Nutrients

View full text Add to dashboard Cite

show abstract

“…This accumulation of lactate causes a decrease in peripheral resistance, thereby increasing venous return to the heart (preload). This increase in preload coupled with myocardial dysfunction has been proposed to be a basis of congestive heart failure in thiamine deficiency [8].…”

Section: Introductionmentioning

confidence: 99%

Thiamine Therapy for Heart Failure: a Promise or Fiction?

Kattoor

Goel

Mehta

2018

Cardiovasc Drugs Ther

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“…Nowadays, in the developed world it is relatively rare [13]. The most common causes are alcoholism (32.26%), digestive system disease and surgery (29.03%), imprisonment (9.68%), furosemide administration (6.45%), a mixture of factors (16.13%), other (3.23%) and unknown (3.23%) [14].…”

Section: Discussionmentioning

confidence: 99%

A rare pulmonary pathology complicated with an unusual condition

Kotoulas

Manika

Pilianidis

et al. 2019

Breathe

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A 73-year-old male presented to the emergency department complaining about fatigue, night sweats, lack of appetite and weight loss for the past 2 months. His baseline weight was 47 kg and his height was 1.78 m (body mass index of 14.83 kg·m −2 ), while at presentation he weighed 39 kg. From his history, he underwent gastrectomy 31 years ago for stomach cancer. He was a smoker (55 pack-years), with no history of alcohol consumption or any other known pathological condition. Despite his gastrectomy, he did not suffer from symptoms suggesting reflux disease. 2 years ago, his daughter suffered from pulmonary tuberculosis, but he was not checked at that time with either a Mantoux test or chest radiograph. Physical examination revealed crackles in both lungs. His heart rate and blood pressure were normal. Because of his gastrectomy, he was on treatment with B12 and folic acid supplements and on presentation he did not reveal megaloblastic anaemia. From his laboratory examinations, his white blood cells were normal (9780 cells·μL −1 (68.4% neutrophils, 21.7% lymphocytes)) while his C-reactive protein was elevated (8.87 mg·dL −1 ). Despite his obviously impaired nutritional status his serum albumin was slightly above the lower normal level (3.67 g·dL −1 ). His chest computed tomography (CT) revealed infiltrations bilaterally, signs of incipient pulmonary fibrosis with thickened interlobular septa, centrilobular nodules and loss of volume of the left lower lobe (figure 1). His blood gas analysis revealed hypoxaemia; therefore, he was admitted to hospital and initiated intravenous antibiotic treatment with ampicillin/sulbactam plus azithromycin.

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Wet beriberi with multiple organ failure remarkably reversed by thiamine administration

Abstract: Supplemental Digital Content is available in the text

Cited by 38 publications

References 31 publications

An Update on Omega-3 Polyunsaturated Fatty Acids and Cardiovascular Health

An Update on Omega-3 Polyunsaturated Fatty Acids and Cardiovascular Health

Thiamine Therapy for Heart Failure: a Promise or Fiction?

A rare pulmonary pathology complicated with an unusual condition

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