Westlake Gut Project: A consortium of microbiome epidemiology for the gut microbiome and health research in China

Gou, Wanglong; Chen, Yuming; Pan, An; Wang, Huijun; Zhang, Ke; Pan, Xiong‐Fei; He, Yan; Fu, Yuanqing; Jiang, Zengliang; Miao, Zelei; Su, Chang; Zhang, Jiguo; Hu, Wensheng; Zeng, Fangfang; Ma, Wenjun; Cheng, Guo; Zhu, Yimin; Zhou, Hongwei; Zhang, Bing; Zheng, Ju‐Sheng

doi:10.1016/j.medmic.2022.100064

Cited by 6 publications

(4 citation statements)

References 34 publications

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“…The present study was based on the gut microbiome cohort consortium: the Westlake Gut Project [ 16 ], including three independent Chinese cohorts: Guangzhou Nutrition and Health Study (GNHS) [ 17 ], Guangdong Gut Microbiome Project (GGMP) [ 18 ], and China Health and Nutrition Survey (CHNS) [ 19 ]. The GNHS is a prospective cohort study conducted in the Guangdong province.…”

Section: Methodsmentioning

confidence: 99%

Early-life exposure to the Great Chinese Famine and gut microbiome disruption across adulthood for type 2 diabetes: three population-based cohort studies

Gou,

Wang,

Tang

et al. 2023

BMC Med

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Background The early life stage is critical for the gut microbiota establishment and development. We aimed to investigate the lifelong impact of famine exposure during early life on the adult gut microbial ecosystem and examine the association of famine-induced disturbance in gut microbiota with type 2 diabetes. Methods We profiled the gut microbial composition among 11,513 adults (18–97 years) from three independent cohorts and examined the association of famine exposure during early life with alterations of adult gut microbial diversity and composition. We performed co-abundance network analyses to identify keystone taxa in the three cohorts and constructed an index with the shared keystone taxa across the three cohorts. Among each cohort, we used linear regression to examine the association of famine exposure during early life with the keystone taxa index and assessed the correlation between the keystone taxa index and type 2 diabetes using logistic regression adjusted for potential confounders. We combined the effect estimates from the three cohorts using random-effects meta-analysis. Results Compared with the no-exposed control group (born during 1962–1964), participants who were exposed to the famine during the first 1000 days of life (born in 1959) had consistently lower gut microbial alpha diversity and alterations in the gut microbial community during adulthood across the three cohorts. Compared with the no-exposed control group, participants who were exposed to famine during the first 1000 days of life were associated with consistently lower levels of keystone taxa index in the three cohorts (pooled beta − 0.29, 95% CI − 0.43, − 0.15). Per 1-standard deviation increment in the keystone taxa index was associated with a 13% lower risk of type 2 diabetes (pooled odds ratio 0.87, 95% CI 0.80, 0.93), with consistent results across three individual cohorts. Conclusions These findings reveal a potential role of the gut microbiota in the developmental origins of health and disease (DOHaD) hypothesis, deepening our understanding about the etiology of type 2 diabetes.

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Section: Methodsmentioning

confidence: 99%

Early-life exposure to the Great Chinese Famine and gut microbiome disruption across adulthood for type 2 diabetes: three population-based cohort studies

Gou,

Wang,

Tang

et al. 2023

BMC Med

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“…The project is expanded with the longitudinal microbiome samples of people suffering from Inflammatory Bowel Disease (IBD), Type-2 diabetes, and preterm birth to understand the impact on the dynamics of human health and disease (The Integrative HMP (iHMP) Research Network Consortium) 67 . Since the human gut microbiota is highly dense and involved in critical host functions, several studies on the European population (MetaHIT 63 , 85 ), African population 2 , and Asian population (Asian Microbiome Project 52 , 97 , Westlake Gut Project 45 ) have been done to investigate the interaction of intestinal microbiota with the human host and the trajectories of microbiota development.…”

Section: Microbiome Databasesmentioning

confidence: 99%

Big Data for a Small World: A Review on Databases and Resources for Studying Microbiomes

et al. 2023

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Microorganisms are ubiquitous in nature and form complex community networks to survive in various environments. This community structure depends on numerous factors like nutrient availability, abiotic factors like temperature and pH as well as microbial composition. Categorising accessible biomes according to their habitats would help in understanding the complexity of the environment-specific communities. Owing to the recent improvements in sequencing facilities, researchers have started to explore diverse microbiomes rapidly and attempts have been made to study microbial crosstalk. However, different metagenomics sampling, preprocessing, and annotation methods make it difficult to compare multiple studies and hinder the recycling of data. Huge datasets originating from these experiments demand systematic computational methods to extract biological information beyond microbial compositions. Further exploration of microbial co-occurring patterns across the biomes could help us in designing cross-biome experiments. In this review, we catalogue databases with system-specific microbiomes, discussing publicly available common databases as well as specialised databases for a range of microbiomes. If the new datasets generated in the future could maintain at least biome-specific annotation, then researchers could use those contemporary tools for relevant and bias-free analysis of complex metagenomics data.

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“…Promisingly, advancements in sequencing technology have facilitated the ongoing accumulation of microbiome data within the Chinese population. The integration of these data with large-scale cohort studies, exempli ed by the Westlake Gut Project [29],…”

Section: Introductionmentioning

confidence: 99%

Potential Roles of Cigarette Smoking on Gut Microbiota Profile among Chinese Men

Fan,

Zeng,

Zhong

et al. 2024

Preprint

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Cigarette smoking is posited as a potential factor in disrupting the balance of the human gut microbiota. However, existing studies with limited sample size have yielded inconclusive results. Here, we assessed the association between cigarette smoking and gut microbial profile among Chinese males from four independent studies (N total = 3,308). Both 16S rRNA and shotgun metagenomic sequencing methods were employed, covering 206 genera and 237 species. Microbial diversity was compared among non-smokers, current smokers, and former smokers. Actinomyces[g], Atopobium[g], Haemophilus[g], Turicibacter[g], and Lachnospira[g] were found to be associated with smoking status (current smokers v.s. non-smokers). Metagenomic data provided a higher resolution at the species level, particularly for the Actinomyces[g] branch. Additionally, serum Trans-3-Hydroxycotinine was found to have a potential role in connecting smoking and Actinomyces[g]. Furthermore, we revealed putative mediation roles of gut microbiome in the associations between smoking and common diseases including cholecystitis and type 2 diabetes. In conclusion, we characterized the gut microbiota profile in male smokers and further revealed their potential involvement in mediating the impact of smoking on health outcomes. These findings advance our understanding of the intricate associations between cigarette smoking and the gut microbiome.

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Westlake Gut Project: A consortium of microbiome epidemiology for the gut microbiome and health research in China

Cited by 6 publications

References 34 publications

Early-life exposure to the Great Chinese Famine and gut microbiome disruption across adulthood for type 2 diabetes: three population-based cohort studies

Early-life exposure to the Great Chinese Famine and gut microbiome disruption across adulthood for type 2 diabetes: three population-based cohort studies

Big Data for a Small World: A Review on Databases and Resources for Studying Microbiomes

Potential Roles of Cigarette Smoking on Gut Microbiota Profile among Chinese Men

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