Western Diet Induced Remodelling of the Tongue Proteome

Dutt, Mriga; Ng, Yaan-Kit; Molendijk, Jeffrey; Karimkhanloo, Hamzeh; Liao, Luoping; Blazev, Ronnie; Montgomery, Magdalene K; Watt, Matthew J.; Parker, Benjamin L.

doi:10.3390/proteomes9020022

Cited by 6 publications

(6 citation statements)

References 61 publications

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“…At the same time, however, there has also been growing interest in the relationship between the composition of oral microbiota and taste perception ( Cattaneo et al, 2019 ). It currently remains an intriguing yet open question as to whether there might also be a relation between gut health and the spatial aspects of taste perception (though see Dutt et al, 2021 , for some intriguing recent data in this regard).…”

Section: Discussionmentioning

confidence: 99%

The tongue map and the spatial modulation of taste perception

Spence¹

2022

Current Research in Food Science

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Section: Discussionmentioning

confidence: 99%

The tongue map and the spatial modulation of taste perception

Spence¹

2022

Current Research in Food Science

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“…A demo dataset of Western diet-induced remodeling of the tongue proteome is included with TeaProt. 17 This dataset and a detailed tutorial are available on the “start” page of TeaProt.…”

Section: Methodsmentioning

confidence: 99%

urPTMdb/TeaProt: Upstream and Downstream Proteomics Analysis

2022

Self Cite

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We have developed the underrepresented posttranslational modification (PTM) database (urPTMdb), a PTM gene set database to accelerate the discovery of enriched protein modifications in experimental data. urPTMdb provides curated lists of proteins reported to be substrates of underrepresented modifications. Their enrichment in proteomics datasets can reveal unexpected PTM regulations. urPTMdb can be implemented in existing workflows, or used in TeaProt, an online Shiny tool that integrates upstream transcription factor enrichment analysis with downstream pathway analysis through an easy-to-use interactive interface. TeaProt annotates user-uploaded data with drug−gene interactions, subcellular localizations, phenotypic functions, gene− disease associations, and enzyme−gene interactions. TeaProt enables gene set enrichment analysis (GSEA) to discover enrichments in gene sets from various resources, including MSigDB, CHEA, and urPTMdb. We demonstrate the utility of urPTMdb and TeaProt through the analysis of a previously published Western diet-induced remodeling of the tongue proteome, which revealed altered cellular processes associated with energy metabolism, interferon alpha/gamma response, adipogenesis, HMGylation substrate enrichment, and transcription regulation through PPARG and CEBPA. Additionally, we analyzed the interactome of ADP-ribose glycohydrolase TARG1, a key enzyme that removes mono-ADP-ribosylation. This analysis identified an enrichment of ADPribosylation, ribosomal proteins, and proteins localized in the nucleoli and endoplasmic reticulum. TeaProt and urPTMdb are accessible at https://tea.coffeeprot.com/.

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“…Diet-induced obesity reduced the oscillation of key genes involved both in the circadian clock and lipid detection/signaling. Previously Dutt and colleagues ( 279 ) had shown that CD36 was increased in extracts of whole mouse tongue. In one study on human FP ( 280 ), the authors found a decrease in transcript levels of several type II TRC proteins (PLCβ2, GNAT3, T1R2, GNG13, TRPM5, T2R31, PKD2L1, and T1R1) and SHH transcript levels in FP from obese versus lean women suggesting loss of SHH signaling could lead to reduced type II cell function in obesity.…”

Section: Effect Of Obesity and Sugar On Tastementioning

confidence: 99%

Physiology of the tongue with emphasis on taste transduction

Doyle

Premathilake

Yao

et al. 2023

Physiological Reviews

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The tongue is a complex multifunctional organ that interacts and senses both interoceptively and exteroceptively. Although it is easily visible to almost all of us it is relatively understudied and what is in the literature as regards taste mechanisms is often contradictory or is not comprehensively reported. The tongue is both a motor and a sensory organ: motor in that it is required for speech and mastication, and sensory in that it receives information to be relayed to the central nervous system pertaining to the safety and quality of the contents of the oral cavity. Additionally, the tongue and its taste apparatus form part of an innate immune surveillance system. For example, loss or alteration in taste perception can be an early indication of infection as became evident during the present global SARS-CoV-2 pandemic. Here we particularly emphasize the latest updates in the mechanisms of taste perception, taste bud formation and adult taste bud renewal, the presence, and effects of hormones on taste perception, review the understudied lingual immune system with specific reference to SARS-CoV-2, discuss nascent work on tongue microbiome, as well as addressing the effect of systemic disease on tongue structure and function, especially in relation to taste.

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Western Diet Induced Remodelling of the Tongue Proteome

Cited by 6 publications

References 61 publications

The tongue map and the spatial modulation of taste perception

The tongue map and the spatial modulation of taste perception

urPTMdb/TeaProt: Upstream and Downstream Proteomics Analysis

Physiology of the tongue with emphasis on taste transduction

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