Western diet given to healthy rats mimics the human phenotype of diabetic cardiomyopathy

Verboven, Maxim; Deluyker, Dorien; Ferferieva, Vesselina; Lambrichts, Ivo; Hansen, Dominique; Eijnde, Bert O.; Bito, Virginie

doi:10.1016/j.jnutbio.2018.08.002

Cited by 16 publications

(23 citation statements)

References 44 publications

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“…However, such diets are not commercially available and combine LMW- and HMW-AGEs, thus prevent studying the distinct role of the HMW-AGEs fraction. We have previously shown that HMW-AGEs IP injection leads to increased circulating AGEs levels comparable to what we also observed in animal models of diabetic cardiomyopathy 20 and does not stimulate a general immune response in these animals 19 , further validating the animal model used in this study.…”

Section: Discussionsupporting

confidence: 86%

“…Hemodynamic measurements were performed under 3% isoflurane anaesthesia supplemented with oxygen. A pre-calibrated SPR-320 rat pressure catheter (AD instruments, Spechbach, Germany) connected to a data acquisition system (PowerLab 4/25 T, AD Instruments) was used to measure hemodynamic parameters in the left ventricle (LV) via the right carotid artery, as described previously 19 , 20 . LV end-systolic pressure (LVESP), mean pressure and end-diastolic pressure (LVEDP) were obtained and calculated with LabChart8 software (AD instruments).…”

Section: Methodsmentioning

confidence: 99%

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Glycolaldehyde-modified proteins cause adverse functional and structural aortic remodeling leading to cardiac pressure overload

Haesen

Cöl

Schurgers

et al. 2020

Sci Rep

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Growing evidence supports the role of advanced glycation end products (AGEs) in the development of diabetic vascular complications and cardiovascular diseases (CVDs). We have shown that high-molecular-weight AGEs (HMW-AGEs), present in our Western diet, impair cardiac function. Whether HMW-AGEs affect vascular function remains unknown. In this study, we aimed to investigate the impact of chronic HMW-AGEs exposure on vascular function and structure. Adult male Sprague Dawley rats were daily injected with HMW-AGEs or control solution for 6 weeks. HMW-AGEs animals showed intracardiac pressure overload, characterized by increased systolic and mean pressures. The contraction response to PE was increased in aortic rings from the HMW-AGEs group. Relaxation in response to ACh, but not SNP, was impaired by HMW-AGEs. This was associated with reduced plasma cyclic GMP levels. SOD restored ACh-induced relaxation of HMW-AGEs animals to control levels, accompanied by a reduced half-maximal effective dose (EC 50 ). Finally, collagen deposition and intima-media thickness of the aortic vessel wall were increased with HMW-AGEs. Our data demonstrate that chronic HMW-AGEs exposure causes adverse vascular remodelling. This is characterised by disturbed vasomotor function due to increased oxidative stress and structural changes in the aorta, suggesting an important contribution of HMW-AGEs in the development of CVDs.

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Section: Discussionsupporting

confidence: 86%

Section: Methodsmentioning

confidence: 99%

Glycolaldehyde-modified proteins cause adverse functional and structural aortic remodeling leading to cardiac pressure overload

Haesen

Cöl

Schurgers

et al. 2020

Sci Rep

Self Cite

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“…There is a hypothesis that caloric restriction induces stress, which triggers the biological pathways that result in gene encoding which influence longevity, aiding in metabolism regulation )showed correlation of WD with intake of red and processed meat, eggs, sauces, fast food, pre-cooked food, whole dairy products and potatoes. Several other studies associate WD with high fat and sugar consumption (Verboven et al, 2018). The breakdown of food groups in WD is given in Figure 4.…”

Section: Effect On Healthmentioning

confidence: 98%

Modern dietary patterns based on territorial origin - a review

Raits¹

2019

Foodbalt

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There are different dietary patterns around the globe formed on the account of various anthropogenic factors: cultural, economic and globalization. Human food consumption patterns can be formulated and defined depending on habitat. For example, since Scandinavian countries are surrounded by seas, fishery was quite developed historically, and even today, seafood constitutes a large part of daily Scandinavian food plate. On the other hand, world globalization has led to the appearance of such unhealthy food consumption patterns as unbalanced nutrition or refined product excess in a daily diet. There is a strong association between unhealthy eating habits and diseases, which means that healthy eating habits could lower a wide range of such disease emergence possibility as metabolic syndrome, type 2 diabetes, and cardiovascular diseases. The review discusses types of modern dietary patterns around the globetheir origins, main principles and effects on health, comparison of nutrient ratios among the most popular dietary patterns (Nordic diet, Mediterranean diet, Okinawa diet) and the "unhealthy" Western diet.

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“…The development of HF is a complex process involving a series of physiological and molecular factors and is characterized by structural and functional disorders that remain incompletely understood. Advanced glycation endproducts (AGEs) are important components of our Western diet as described previously by our group [3], and are thought to contribute to the development and progression of CVDs [4]. AGEs are a collective term for the heterogeneous group of compounds formed by irreversible glycation of proteins [5,6].…”

Section: Introductionmentioning

confidence: 95%

Glycolaldehyde-Derived High-Molecular-Weight Advanced Glycation End-Products Induce Cardiac Dysfunction through Structural and Functional Remodeling of Cardiomyocytes

Deluyker

Evens

Haesen

et al. 2020

Cell Physiol Biochem

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Western diet given to healthy rats mimics the human phenotype of diabetic cardiomyopathy

Cited by 16 publications

References 44 publications

Glycolaldehyde-modified proteins cause adverse functional and structural aortic remodeling leading to cardiac pressure overload

Glycolaldehyde-modified proteins cause adverse functional and structural aortic remodeling leading to cardiac pressure overload

Modern dietary patterns based on territorial origin - a review

Glycolaldehyde-Derived High-Molecular-Weight Advanced Glycation End-Products Induce Cardiac Dysfunction through Structural and Functional Remodeling of Cardiomyocytes

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