West Nile Virus infection with hearing loss

McBride, Wes; Gill, Kanwar R.; Wiviott, Lory D.

doi:10.1016/j.jinf.2006.01.017

Cited by 14 publications

(11 citation statements)

References 11 publications

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“…Similar to other neurologic symptoms, hearing loss is also reported more frequently in immunocompromised patients and often recovers spontaneously (Jamison, Michaels, Ratard, Sweet, & Deboisblanc, 2007; McBride, Gill, & Wiviott, 2006). However, at least one case of SNHL in a WNV-infected, immunocompetent man did not resolve, leaving this patient with a permanent downsloping moderate to severe SNHL (Casetta et al., 2011).…”

Section: Viruses Causing Acquired Hearing Lossmentioning

confidence: 87%

Viral Causes of Hearing Loss: A Review for Hearing Health Professionals

2014

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A number of viral infections can cause hearing loss. Hearing loss induced by these viruses can be congenital or acquired, unilateral or bilateral. Certain viral infections can directly damage inner ear structures, others can induce inflammatory responses which then cause this damage, and still others can increase susceptibility or bacterial or fungal infection, leading to hearing loss. Typically, virus-induced hearing loss is sensorineural, although conductive and mixed hearing losses can be seen following infection with certain viruses. Occasionally, recovery of hearing after these infections can occur spontaneously. Most importantly, some of these viral infections can be prevented or treated. For many of these viruses, guidelines for their treatment or prevention have recently been revised. In this review, we outline many of the viruses that cause hearing loss, their epidemiology, course, prevention, and treatment.

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Section: Viruses Causing Acquired Hearing Lossmentioning

confidence: 87%

Viral Causes of Hearing Loss: A Review for Hearing Health Professionals

2014

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“…Newborn rats infected intracerebrally had higher elicitation and inhibition thresholds than control animals (12). However, the mechanisms of hearing loss associated with viral infections still remain largely elusive (6,8,(12)(13)(14)(15).…”

mentioning

confidence: 99%

Animal Model of Sensorineural Hearing Loss Associated with Lassa Virus Infection

Yun

Ronca

Tamura

et al. 2016

J Virol

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Approximately one-third of Lassa virus (LASV)-infected patients develop sensorineural hearing loss (SNHL) in the late stages of acute disease or in early convalescence. With 500,000 annual cases of Lassa fever (LF), LASV is a major cause of hearing loss in regions of West Africa where LF is endemic. To date, no animal models exist that depict the human pathology of LF with associated hearing loss. Here, we aimed to develop an animal model to study LASV-induced hearing loss using human isolates from a 2012 Sierra Leone outbreak. We have recently established a murine model for LF that closely mimics many features of human disease. In this model, LASV isolated from a lethal human case was highly virulent, while the virus isolated from a nonlethal case elicited mostly mild disease with moderate mortality. More importantly, both viruses were able to induce SNHL in surviving animals. However, utilization of the nonlethal, human LASV isolate allowed us to consistently produce large numbers of survivors with hearing loss. Surviving mice developed permanent hearing loss associated with mild damage to the cochlear hair cells and, strikingly, significant degeneration of the spiral ganglion cells of the auditory nerve. Therefore, the pathological changes in the inner ear of the mice with SNHL supported the phenotypic loss of hearing and provided further insights into the mechanistic cause of LF-associated hearing loss. IMPORTANCESensorineural hearing loss is a major complication for LF survivors. The development of a small-animal model of LASV infection that replicates hearing loss and the clinical and pathological features of LF will significantly increase knowledge of pathogenesis and vaccine studies. In addition, such a model will permit detailed characterization of the hearing loss mechanism and allow for the development of appropriate diagnostic approaches and medical care for LF patients with hearing impairment.

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“…On the other hand, two previous reports seem to support this interpretation [9,10]. This case suggests that hearing impairment can be an unusual clinical feature of WNV infection, and that WNV should be added to the list of viruses potentially responsible for SNHL.…”

Section: Dear Sirsmentioning

confidence: 52%

“…While AFP is a well recognized neurological picture in WNV [2][3][4], SNHL has been described only in two cases [9,10]. Both were immunocompromised patients and presented a concurrent AFP.…”

Section: Dear Sirsmentioning

confidence: 99%

West Nile virus neuroinvasive disease presenting with acute flaccid paralysis and bilateral sensorineural hearing loss

et al. 2011

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West Nile virus (WNV), is an emerging virus. Most human infections are subclinical or manifest as a mild febrile illness, while fewer than 1% develop a neuroinvasive disease (WNND), including meningitis, encephalitis, and/or an acute flaccid paralysis (AFP) . We describe a case of sensorineural hearing loss (SNHL) secondary to WNV infection. A 55 year-old previously healthy and normoacousic man, was admitted (in September 2010) for bilateral hearing loss and leg weakness. This case suggests that hearing impairment can be an unusual clinical feature of WNV infection, and that WNV should be added to the list of viruses potentially responsible for SNHL

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West Nile Virus infection with hearing loss

Cited by 14 publications

References 11 publications

Viral Causes of Hearing Loss: A Review for Hearing Health Professionals

Viral Causes of Hearing Loss: A Review for Hearing Health Professionals

Animal Model of Sensorineural Hearing Loss Associated with Lassa Virus Infection

West Nile virus neuroinvasive disease presenting with acute flaccid paralysis and bilateral sensorineural hearing loss

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