Wertheim Hysterectomy in the Treatment of Endometrial Carcinoma

Parsons, Langdon; Cesare, Frank

doi:10.1097/00006254-195901000-00046

Cited by 3 publications

(5 citation statements)

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“…Spread from the corpus to the cervix and parametrium was continuous. We did not find evidence of lymphatic spread or involvement of parametrial lymph nodes like that seen in cervical cancer (14) , but two earlier studies (4,15) have mentioned this finding in endometrial carcinoma.…”

Section: Discussioncontrasting

confidence: 62%

“…The isolated pelvic recurrence rate in our series was 8%, even without routine adjuvant radiation therapy. Earlier studies on radical hysterectomy in endometrial cancer (4–7) are hard to evaluate because the patients were staged clinically according to the old FIGO system and many received preoperative radiation.…”

Section: Discussionmentioning

confidence: 99%

“…The current FIGO staging system (3) is based on surgical‐pathologic findings but does not take into account parametrial extension. Early series on radical hysterectomy in endometrial cancer (4–6) are hard to evaluate because the patients were staged clinically and many received preoperative radiation. Other large series on surgical‐pathologic staging of endometrial carcinoma also have not provided detail on parametrial spread (2,7,8) .…”

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confidence: 99%

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Parametrial spread in patients with endometrial carcinoma undergoing radical hysterectomy

Tamussino

Reich

Güçer

et al. 2000

Int J Gynecol Cancer

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The objective of this paper is to study parametrial involvement in patients with endometrial carcinoma undergoing radical hysterectomy. We reviewed indications for surgery, pathology findings, and outcome of a series of 24 patients with endometrial carcinoma who underwent radical hysterectomy. The uterus, cervix and parametrial tissue were processed as step-serial sections. Histologically, 16 patients (67%) had carcinoma involving the cervix. Two of these patients (8%) had frank histologic parametrial involvement and four (17%) had disease extending to the transitional zone of the cervix. Parametrial involvement was continuous and seen only in patients with involvement of the cervical stroma. Six patients (25%) had pelvic node metastases. With a median follow-up of 53 months (range 2-140), four patients (17%) developed recurrences (all within 24 months). Twelve patients (50%), including one of the two with parametrial invasion, were free of disease for 5 years or longer. We conclude that direct parametrial extension can occur in locally advanced endometrial cancer. Radical hysterectomy with lymphadenectomy can be an adequate operation for such patients.

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Section: Discussioncontrasting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Parametrial spread in patients with endometrial carcinoma undergoing radical hysterectomy

Tamussino

Reich

Güçer

et al. 2000

Int J Gynecol Cancer

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“…72 Some (but not all) retrospective studies have suggested a survival advantage associated with radical hysterectomy for endometrial cancer with involvement of the cervix. 73,74 The type of hysterectomy (simple vs modified vs radical) was not an independent prognostic factor associated with recurrence or survival in a pooled analysis of Japanese patients who had endometrial cancer with suspected gross cervical involvement at diagnosis. 75 Because risk factors for endometrial cancer, such as diabetes and obesity, also are risk factors for surgical complications, the increased risks of radical surgery need to be considered.…”

Section: Surgery When Cervical Involvement Is Presentmentioning

confidence: 93%

Current recommendations and recent progress in endometrial cancer

Brooks

Fleming

Lastra

et al. 2019

CA A Cancer J Clinicians

447

372

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Endometrial cancer is the most common gynecologic cancer in the United States, and its incidence is rising. Although there have been significant recent advances in our understanding of endometrial cancer biology, many aspects of treatment remain mired in controversy, including the role of surgical lymph node assessment and the selection of patients for adjuvant radiation or chemotherapy. For the subset of women with microsatellite‐instable, metastatic disease, anti– programmed cell death protein 1 immunotherapy (pembrolizumab) is now approved by the US Food and Drug Administration, and numerous trials are attempting to build on this early success.

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“…A lesion located in the fundus is known to spread more slowly on average than processes in the isthmus and endocervix. Kottmeier, Parsons and Cesare advised already in 1959 more radical operative treatment for endometrial carcinoma of the lower segments (6,9). Tumors of the fundus spread via the subovarian plexus and the ligamentum infundibulopelvicum cranially into the para-aortal lymph nodes and sometimes along the ligamentum rotundum into the inguinal nodes.…”

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confidence: 99%

Methods for evaluating the intrauterine location of carcinoma

Liukko

Grönroos

Punnonen

et al. 1979

Acta Obstet Gynecol Scand

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The intrauterine location of endometrial carcinoma was investigated with curettage, hysterography and hysteroscopy in 83 patients. These three methods are complementary. Curettage provides important information about the differentiation of the tumor. Hysterography is suitable especially for elucidating the anatomy of the cervical canal and uterine cavity. Direct examination by hysteroscopy gives a reliable picture when defining the boundary between stages I and II.

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Wertheim Hysterectomy in the Treatment of Endometrial Carcinoma

Cited by 3 publications

References 0 publications

Parametrial spread in patients with endometrial carcinoma undergoing radical hysterectomy

Parametrial spread in patients with endometrial carcinoma undergoing radical hysterectomy

Current recommendations and recent progress in endometrial cancer

Methods for evaluating the intrauterine location of carcinoma

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