Wernicke’s Encephalopathy as a Rare Complication of Hyperemesis Gravidarum: A Case Report and Review of Literature

Nagarajan, Elanagan; Rupareliya, Chintan; Bollu, Pradeep C.

doi:10.7759/cureus.2597

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…Visual symptoms have been described as a prodromal characteristic of WE in other populations that have forms of malnutrition, such as anorexia nervosa [165], dietary issues [168,169], and some cancers [170]. In alcoholics, patients with WE often lack any awareness of their own illness, reducing the chance they will present to emergency services with visual disturbances [141,144]. In clinical practice, visual disturbance in HG specifically warrants attention for possible thiamine deficiency.…”

Section: Discussionmentioning

confidence: 99%

Wernicke’s encephalopathy in hyperemesis gravidarum: A systematic review

Oudman

Wijnia

Oey

et al. 2019

European Journal of Obstetrics & Gynecology and Reproductiv

127

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Section: Discussionmentioning

confidence: 99%

Wernicke’s encephalopathy in hyperemesis gravidarum: A systematic review

Oudman

Wijnia

Oey

et al. 2019

European Journal of Obstetrics & Gynecology and Reproductiv

127

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“…The diagnosis is mainly clinical and confirmed by characteristic MRI findings and dramatic clinical response to thiamine. A high index of suspicion is required for early diagnosis of WE in HG, and early initiation of thiamine supplementation is essential [ 8 - 10 ]. Bonucchi et al have reported a case where the hypermetabolic state from thyrotoxicosis in a patient with HG contributed to the development of WE.…”

Section: Discussionmentioning

confidence: 99%

Wernicke’s Encephalopathy Associated With Transient Gestational Hyperthyroidism and Hyperemesis Gravidarum

Ahmed¹,

Ahmed²,

Salah³

et al. 2020

Cureus

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Wernicke's encephalopathy (WE) is a potentially reversible yet severe neurological manifestation caused by thiamine (vitamin B1) deficiency. It is commonly associated with heavy alcohol consumption. Other rare causes include severe and prolonged vomiting, starvation, and prolonged intravenous feeding. WE patients usually present with the triad of ocular signs, ataxia, and confusion. In non-alcoholic patients, the full classic triad develops in 10-16% of cases. Characteristic MRI findings and clinical response to thiamine confirm the diagnosis. In this report, we present a case of WE in the setting of transient gestational hyperthyroidism and hyperemesis gravidarum (HG).

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“…[11,12] Moreover, has some catastrophic consequences such as central pontine myelinolysis, Wernicke's encephalopathy, vasospasm of cerebral arteries, rabdomyolysis, coagulopathy, and maternal and fetal death. [13][14][15] While HG generally occurs between the 8 th and 10 th gestational weeks of pregnancy, in 10% of all HG cases, it persists until the birth. [12] Previous HG history, multiple and molar pregnancy, gestational trophoblastic neoplasia, hyperthyroidism, gastrointestinal disorders, female offspring, and psychiatric disorders are the main risk factors for HG.…”

mentioning

confidence: 99%

The Association between Hyperemesis Gravidarum and Periodontal Disease in Pregnancy

Altaş

Boyama

Çakmak³

2020

European Journal of General Dentistry

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Periodontal diseases (PDs) are common chronic infections affecting tooth-supporting tissues, with an incidence of 46% of the adult population in the United States. [1] It is probably caused by the disequilibrium between infectious pathogens and host-immune response. [2] PDs are considered a potential risk factor for some systemic inflammatory conditions such as cardiovascular diseases, rheumatoid arthritis, diabetes mellitus, and respiratory diseases. [3,4] Moreover, it has been found to be related with adverse pregnancy outcomes, and the main accused mechanism is inflammation for such adverse events. [5] Previous studies have demonstrated that pregnant women with PD have a higher incidence of low-birth weight, preterm birth, and preeclampsia. [6,7] The effect of periodontal inflammation on adverse pregnancy outcomes has been theorized with two different pathways: direct and indirect. First, periodontal bacteria and/or their pathogenic products may directly spread to the fetal-placental unit hematologically or along the genitourinary tract from the oral cavity. Indirectly, local inflammatory mediators such as prostaglandin E2 (PGE2) and tumor necrosis factor-alpha (TNF)-α, which are produced in response to periodontal pathogens may enter the bloodstream, arrive the fetal-placental unit, and amplify the accumulation of this mediators. Similarly, they enter the liver and increase acute-phase protein reaction such as C-reactive protein (CRP) synthesis, and by this way, inflammation in the fetal-placental unit may become more severe. [2] Furthermore, it has been considered that pregnancy could increase the severity of PDs due to hormonal changes.

show abstract

Wernicke’s Encephalopathy as a Rare Complication of Hyperemesis Gravidarum: A Case Report and Review of Literature

Cited by 3 publications

References 9 publications

Wernicke’s encephalopathy in hyperemesis gravidarum: A systematic review

Wernicke’s encephalopathy in hyperemesis gravidarum: A systematic review

Wernicke’s Encephalopathy Associated With Transient Gestational Hyperthyroidism and Hyperemesis Gravidarum

The Association between Hyperemesis Gravidarum and Periodontal Disease in Pregnancy

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