Wernicke’s encephalopathy: a case report and mri findings

Yücebilgin, Sait; Çırpan, Teksin; Cy, Sanhal; Ozan, Erol; Acar, Türker; Ozsener, S

doi:10.5334/jbr-btr.480

Cited by 5 publications

(5 citation statements)

References 10 publications

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“…Although 12 kg is relatively high, weight loss in excess of 12 kg is not uncommon in HG [9]. In our review, one case study specifically reported on extreme weight loss through combined obesity surgery and later development of HG [101], and another case had pre-existent anorexia nervosa combined with HG [89]. Thiamine is an essential nutrient for successful carbohydrate metabolism in the brain.…”

Section: Main Findingsmentioning

confidence: 86%

Wernicke’s encephalopathy in hyperemesis gravidarum: A systematic review

Oudman

Wijnia

Oey

et al. 2019

European Journal of Obstetrics & Gynecology and Reproductiv

127

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Section: Main Findingsmentioning

confidence: 86%

Wernicke’s encephalopathy in hyperemesis gravidarum: A systematic review

Oudman

Wijnia

Oey

et al. 2019

European Journal of Obstetrics & Gynecology and Reproductiv

127

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Section: Discussionmentioning

confidence: 99%

“…Restricted diffusion may be due to a breakdown of cell membranes as thiamine plays an important role in maintaining osmotic balance across cell membranes. Another hypothesis involves a form of vasculopathy 16,17 . There is usually not much difference between alcoholic and non-alcoholic WE but long-standing thiamine deficiency as occurs more often in alcoholics may show associated vermian atrophy and contrast enhancement of the mammillary bodies 3 which is due to blood-brain barrier disruption and a feature of long-term thiamine deficiency 19,20 .…”

Section: Discussionmentioning

confidence: 99%

“…One of our patients showed extensive signal changes, from the thalami to the dorsal medulla, while the others had more restricted involvement. Diffusion-weighted imaging (DWI) reveals diffusion restriction and has been recommended to enhance the sensitivity of MRI in making a diagnosis 16,17 . The signal change corresponds to spongy degeneration of neuropil 2,18 .…”

Section: Discussionmentioning

confidence: 99%

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Wernicke's Encephalopathy following Hyperemesis Gravidarum

Kotha

Souza

2013

Neuroradiol J

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SUMMARY -Wernicke's encephalopathy (WE) due to causes other than chronic alcohol abuse is an uncommon and often misdiagnosed condition. In the setting of hyperemesis gravidarum, an acute deficiency of thiamine results from body stores being unable to meet increased metabolic demands. The condition produces typical clinical and radiological findings and when diagnosed early and treated promptly has a good prognosis. Magnetic resonance imaging (MRI) is sensitive and specific for diagnosis. We describe three patients with hyperemesis gravidarum who developed WE, and highlight a range of clinical and imaging features important for appropriate diagnosis. A high degree of clinical suspicion is essential. Treatment is often empirical pending results of investigation, and consists of parenteral repletion of thiamine stores. Reversal of MRI findings parallels clinical improvement. Neurologic outcomes are usually good, but half the pregnancies complicated by this condition do not produce healthy children.

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“…WE'nin klinisyenler, beslenme uzmanları ve radyoloji uzmanları tarafından yeterince bilinmemesi, ayrıca sağlık politikalarının dolaylı etkisi sonucu hastanelerin ilaç teminindeki sıkıntılar gibi etkenler nedeniyle tüm dünyada olduğu gibi, ülkemizde de bu hastalığın tahmin edilenden daha sık görülüyor olması ve görülmeye devam edeceği kuvvetle muhtemeldir (14,15). Farkındalığın arttırılması ile daha çok sayıda vaka erken tanı alabilir ve tedavi edilebilir.…”

Section: Sonuçunclassified

Three Iatrogenic Cases of Wernicke’s Encephalopathy From Turkey: An Early Warning

Vural¹,

Temuçin²,

Arsava³

et al. 2011

Yoğun Bakim Derg

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Wernicke's encephalopathy (WE) is classically known as a disease which presents with encephalopathy, ataxia and ophtalmoparesis and is commonly observed in alcoholics due to nutritional deficiency. Recently, an increasing number of case reports and research articles in the literature has shown that this disease may be seen in nonalcoholics much more frequently than previously acknowledged. Apart from patients with cancer, hyperemesis gravidarum and bariatric surgical interventions, long-term hospitalised patients receiving total parenteral nutrition (TPN) without multivitamin supplementation are at risk for iatrogenic WE. Iatrogenic cases have been reported in many countries, especially during periods when changes in national health insurance policies take place. In this report, we present three patients who were diagnosed with iatrogenic WE after long-term hospitalisation and discuss predisposing factors as well as diagnostic and therapeutic issues related to this entity. (Yoğun Bakım Derg 2011; 3: 71-5)

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Wernicke’s encephalopathy: a case report and mri findings

Cited by 5 publications

References 10 publications

Wernicke’s encephalopathy in hyperemesis gravidarum: A systematic review

Wernicke’s encephalopathy in hyperemesis gravidarum: A systematic review

Wernicke's Encephalopathy following Hyperemesis Gravidarum

Three Iatrogenic Cases of Wernicke’s Encephalopathy From Turkey: An Early Warning

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