Werner's Syndrome with Myelofibrosis Following Diphenylhydantoin Therapy after Meningiomectomy

Noda, Makoto; Matsui, Kazuhiro; Kitagawa, Masanobu; Ohta, Masayuki

doi:10.1111/j.1532-5415.1990.tb01599.x

Cited by 5 publications

(5 citation statements)

References 19 publications

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“…Gross and histopathologic changes at autopsy in our four patients closely resembled prior autopsy findings in WS191112131415161718192021 (Table 3), and together document multisystem disease affecting the skin, cardiovascular and respiratory system in all four patients. There was advanced atherosclerotic peripheral vascular disease together with evidence of recent or remote myocardial and cerebral infarction, and three instances of neoplasia: metastatic pancreatic adenocarcinoma with liver and lung metastases in Patients 3 and 4; multiple meningiomas in Patient 2; and a pulmonary carcinoid in Patient 4.…”

Section: Discussionsupporting

confidence: 81%

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Werner syndrome through the lens of tissue and tumour genomics

Tokita

Kennedy

Risques

et al. 2016

Sci Rep

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Werner syndrome (WS) is the canonical adult human progeroid (‘premature aging’) syndrome. Patients with this autosomal recessive Mendelian disorder display constitutional genomic instability and an elevated risk of important age-associated diseases including cancer. Remarkably few analyses of WS patient tissue and tumors have been performed to provide insight into WS disease pathogenesis or the high risk of neoplasia. We used autopsy tissue from four mutation-typed WS patients to characterize pathologic and genomic features of WS, and to determine genomic features of three neoplasms arising in two of these patients. The results of these analyses provide new information on WS pathology and genomics; provide a first genomic characterization of neoplasms arising in WS; and provide new histopathologic and genomic data to test several popular models of WS disease pathogenesis.

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Section: Discussionsupporting

confidence: 81%

“…We used previously published WS pathology reports191112131415161718192021 to develop a list of recurrent clinical and histopathologic findings in WS, then scored these findings in each of our patients (Tables 2 and 3, Supplementary Methods and Results). Scleroderma-like skin changes were present, though variable, in all four patients.…”

Section: Resultsmentioning

confidence: 99%

Werner syndrome through the lens of tissue and tumour genomics

Tokita

Kennedy

Risques

et al. 2016

Sci Rep

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“…These side effects can reduce a patient's ability to participate in his or her own recovery and impair quality of life. 6,19,20,31 Thus, a blanket statement of whether AEDs are good or bad for all patients undergoing craniotomy for a brain tumor is probably oversimplistic. 31 While our data suggested that the rate of seizures following surgery for convexity meningiomas is very low without medications, we think it is important to note that these rates might not necessarily extrapolate to surgery for other tumor types or for meningiomas located at different sites.…”

Section: Discussionmentioning

confidence: 99%

Postoperative seizures following the resection of convexity meningiomas: are prophylactic anticonvulsants indicated?

Sughrue

Rutkowski

Chang

et al. 2011

JNS

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“…1,3,6-10,12,13, [16][17][18][20][21][22][23][24][25][26][27][28][29][30]32,33,35,36) Twenty-three of the 33 meningiomas were reported in Japan. The male to female ratio in the patients with meningioma (23:10) may be higher than that in patients without Werner syndrome (1:2).…”

Section: Discussionmentioning

confidence: 99%

“…Eight cases of meningiomas, including our case, have been complicated with other neoplasms in patients with Werner syndrome. 2,6,7,[23][24][25][26]28) Our patient had intracranial meningiomas associated with leg osteosarcoma. According to the literature, 5) the only one patient who had intracranial meningiomas associated with orbital osteosarcoma, fibroliposarcoma of the soft tissue, and hepatoma was reported in 1960.…”

Section: Discussionmentioning

confidence: 99%

Meningioma Associated With Werner Syndrome -Case Report-

Tsurubuchi

Yamamoto

et al. 2008

Neurol. Med. Chir.(Tokyo)

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A 53-year-old man presented with a rare meningioma associated with Werner syndrome. Screening brain magnetic resonance (MR) imaging with gadolinium had detected multiple homogeneously enhanced tumors in the right convexity and in the anterior and posterior thirds of the falx cerebri after surgery for osteosarcoma in his right leg at age 52 years. Ten months later, the right convexity tumor was removed because follow-up MR imaging detected tumor growth. The histological diagnosis was transitional meningioma. The postoperative clinical course was good and the patient remains healthy. Review of the literature found meningiomas associated with Werner syndrome occur about two times more frequently in men than in women, and typically in the fourth decade. Most meningiomas associated with Werner syndrome are benign, but are sometimes complicated with extracranial tumors such as sarcoma, thyroid carcinoma, and others. Patients with meningioma associated with Werner syndrome should be carefully followed up to detect the occurrence of other extracranial tumors such as sarcoma by brain MR imaging, echography, or body computed tomography.

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Werner's Syndrome with Myelofibrosis Following Diphenylhydantoin Therapy after Meningiomectomy

Cited by 5 publications

References 19 publications

Werner syndrome through the lens of tissue and tumour genomics

Werner syndrome through the lens of tissue and tumour genomics

Postoperative seizures following the resection of convexity meningiomas: are prophylactic anticonvulsants indicated?

Meningioma Associated With Werner Syndrome -Case Report-

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