2022
DOI: 10.1007/s11033-022-08178-3
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Werner helicase is required for proliferation and DNA damage repair in multiple myeloma

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Cited by 2 publications
(2 citation statements)
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“…Finally, mRNA expression of WRN is also increased in MM patients compared with normal plasma cells. NSC19630, a specific WRN helicase inhibitor, induces increased DNA damage and apoptosis in preclinical models of MM [ 63 ].…”
Section: Ddr and Dna Repair In Normal Tissues And In MMmentioning
confidence: 99%
“…Finally, mRNA expression of WRN is also increased in MM patients compared with normal plasma cells. NSC19630, a specific WRN helicase inhibitor, induces increased DNA damage and apoptosis in preclinical models of MM [ 63 ].…”
Section: Ddr and Dna Repair In Normal Tissues And In MMmentioning
confidence: 99%
“…The Werner syndrome ATP-dependent helicase (WRN) is a RecQ enzyme involved in the maintenance of genome integrity. WRN is associated with Werner syndrome and a predisposition to multiple cancers, such as multiple myeloma [ 28 ], myelodysplastic syndrome/acute myeloid leukemia [ 29 ], colorectal cancer [ 30 ], breast cancer [ 31 ], and ovarian cancer [ 32 ]. WRN contributes to chromosomal stability for survival in both normal and cancer cells [ 33 ].…”
Section: Discussionmentioning
confidence: 99%