Wenjing decoction (herbal medicine) for the treatment of primary dysmenorrhea: a systematic review and meta-analysis

Gao, Li; Jia, Chunhua; Zhang, Heng; Ma, Cuilan

doi:10.1007/s00404-017-4485-7

Cited by 25 publications

(17 citation statements)

References 18 publications

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“…Wenjing formulae are among the most commonly prescribed remedies for primary dysmenorrhea [3], of which several contain Paeonia spp [24]. Herbal medicine may be advantageous since those used for the treatment of primary dysmenorrhea tend to have analgesic effect [25].…”

Section: Discussionmentioning

confidence: 99%

“…A bibliometric review of modern literatures shows that GZFL is among the most frequently prescribed Chinese herbal formula for the treatment of endometriosisrelated symptomatic discomfort [1,2]. GZFL formula and several similar Wenjing decoctions have demonstrated equal or superior activities against symptoms of primary dysmenorrhea [3]. Given in combination with other drugs, it significantly reduces the volume of fibroids, compared to administration of only the allopathic drug.…”

Section: Introductionmentioning

confidence: 99%

“…Use of hormonal birth control may improve symptoms of primary dysmenorrhea, but they may induce amenorrhea [12]. As mentioned above, complementary and alternative medicines have also demonstrated effectiveness against primary dysmenorrhea [3,13].…”

Section: Introductionmentioning

confidence: 99%

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Guizhi Fuling Capsule Exhibits Antidysmenorrhea Activity by Inhibition of Cyclooxygenase Activity

Zheng

Wang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Guizhi Fuling capsule (GZFLc) is a modern preparation from traditional Chinese Medicine. Guizhi Fuling was first prescribed by Zhang Zhongjing almost two thousand years ago for the treatment of primary dysmenorrhea. It has also been used to treat uterine fibroids, dysfunctional uterine bleeding, and endometriosis. Although effective against dysmenorrhea clinically, there are limited information on the mechanism of its action. The major components responsible for the activity are not well defined. The aim of this study has been to elucidate a mechanism that may facilitate the development of a bioactivity-based assay for quality control during drug formulation and manufacturing. Using an oxytocin-induced mouse dysmenorrhea model, we showed that oral administration of GZFLc at 150 and 300 mg/kg, dosages relevant to clinic usages, significantly suppressed oxytocin-induced writhing response. The antidysmenorrhea effect was also demonstrated by a rotarod assay. We showed that GZFLc treatment significantly prolonged the hanging time of mice on the rotating rod. Histological studies showed that GZFLc treatment reduced lamina propria edema, while no effect on COX2 expression was detected. GZFLc instead exhibited direct inhibitory effect against COX2, a critical enzyme that catalyzes arachidonic acid conversion to prostaglandins. By HPLC profiling, we showed that paeoniflorin, paeonol, and cinnamaldehyde are the major components from the corresponding plants. At 5 and 10 mg/kg, both paeoniflorin and paeonol were active against induced dysmenorrhea. The study not only links GZFLc antidysmenorrhea activity to COX2 inhibition but also uncovers a mechanism of action by which an assay can be developed for bioefficacy evaluation of GZFLc.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Guizhi Fuling Capsule Exhibits Antidysmenorrhea Activity by Inhibition of Cyclooxygenase Activity

Zheng

Wang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…Stress responses include activation of the sympathetic nervous system and release of various hormones and peptides. More prostaglandin and vasopressin are produced which causes an increase in uterine muscle contractions and cramps that cause dysmenorrhea 13,14 .…”

Section: Introductionmentioning

confidence: 99%

Spiritual relaxation to reduce dysmenorrhea: a quasy experimental

A'yun

Mukhoirotin

2020

medisians

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Background: The dysmenorrhea prevalence is still reported high in the world. Several previous studies discovered that deep breathing relaxation effectively reduced dysmenorrhea. Other studies presented the combination of early mobilization and spiritual relaxation could reduce the level of client pain postoperative appendectomy, however the effectiveness of spiritual relaxation techniques to reduce dysmenorrhea is not yet tested.Objective: to determine the effect of spiritual relaxation to reduce dysmenorrhea.Method: The research design used was Quasi Experiment with the pretest-posttest Control Group Design approach. The populations were female students who experienced menstrual pain (dysmenorrhea) and met the inclusion and exclusion criteria. The variable in this study was dysmenorrhea. The sampling technique was simple ramdom sampling consisted of 44 respondents. The calculation instrument was NRS (Numeric Rating Scale) and data were analyzed through statistical test of Paired T-Test and Independent T-Test.Results: After spiritual relaxation treatment, the intensity of menstrual pain reduced significantly from 6.05 - 1.77, it proved that there was an effect of spiritual relaxation on dysmenorrhea with a significant value (ρ) of 0.000 (p ≤ 0.05). There were significant differences in the intensity of menstrual pain in the intervention and control groups (1.77 ± 1,109 vs 5.63 ± 0.445; p> 0.05).Conclusion: Spiritual relaxation effectively reduces dysmenorrhea

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“…It has been proved that PD was associated with the hypercontractility of uterine smooth muscle and spiral artery of uterine wall, so that inducing ischemia and hypoxia and triggering pain in the hypogastrium [6,7] . Recently years, many studies have de ned the over synthesis of prostaglandin in the endometrium as the dominant reason for PD, especially the PGF2α and PGF2 that play a fundamental role in increasing uterine muscle tone and high-intensity contraction, triggering the acid metabolites adding up in the myometrium thus causing pain [8][9][10][11] . Otherwise, some studies suggests that ET and NO are also important factors causing primary dysmenorrhea, those mainly regulates uterine vascular tone and blood ow [12] .…”

Section: Introductionmentioning

confidence: 99%

A Protocol to Develop Practical Guidelines for Management of Primary Dysmenorrhea with Moxibustion

Huang

Xiong²,

Yong³

et al. 2020

Preprint

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Background: Primary dysmenorrhea (PD) is a common gynecological disease characterized by lower abdominal pain. Moxibustion as a traditional Chinese treatment, can effectively treat PD with few adverse reactions. Nowadays, there is still no standard guideline for moxibustion treatment of PD, so related clinical practice guidelines (CPG) need to be developed.Methods: This guideline will be developed in line with the latest guideline definition from Institute of Medicine(IOM), and that applies the GRADE system as well as the World Health Organization handbook to appraise the quality of evidence and develop recommendations. We will set up a Guideline working group, put forward the corresponding problems based on the principle of Population, Intervention, Comparison, Outcomes(PICO), and complete the literature retrieval. After achieving consensus through evidence syntheses and 2-3 rounds of Delphi process, we will also consider patients values and preferences and implement peer review in the guideline.Result: We will put forward evidence-based best practice recommendations and moxibustion standard to improve the symptoms caused by primary dysmenorrhea in a more efficient way. At present, the research is still in progress, and there is no result to report.Conclusions: This guideline will be helpful to clinical acupuncturists and other professionals to further improve clinical efficacy in treating PD with moxibustion. Moreover, we will also constantly update and evaluate the evidence to both support recommendations and identify gap areas for future research.Systematic Review registrations: registration number: IPGRP-2020CN021

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Wenjing decoction (herbal medicine) for the treatment of primary dysmenorrhea: a systematic review and meta-analysis

Cited by 25 publications

References 18 publications

Guizhi Fuling Capsule Exhibits Antidysmenorrhea Activity by Inhibition of Cyclooxygenase Activity

Guizhi Fuling Capsule Exhibits Antidysmenorrhea Activity by Inhibition of Cyclooxygenase Activity

Spiritual relaxation to reduce dysmenorrhea: a quasy experimental

A Protocol to Develop Practical Guidelines for Management of Primary Dysmenorrhea with Moxibustion

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