Wells' Syndrome Associated with Coxsackievirus A6 Infection

Yoshii, Yuta; Ishikawa, Takahiro; Munetsugu, Takichi; Nishizawa, Aya; Fujimoto, Norihiro; Satoh, Takahiro

doi:10.2340/00015555-2985

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…The pathogenesis of Wells' syndrome is mostly unclear. It is suggested that the disease depicts a hypersensitivity response to various endogenous and exogenous stimuli such as cutaneous fungal, viral and parasitic infections, insect bites, leukemia, medications, and vaccination [9][10][11][12]. However, the pathogenesis is discussed controversially, as it is also hypothesized that Wells' syndrome is simply a histopathological reaction in diseases with hypereosinophilia.…”

Section: Clinical Lettermentioning

confidence: 99%

Dupilumab in eosinophilic cellulitis (Wells’ syndrome) – case report of a potential new treatment option

Traidl

Angela

Kapp

et al. 2021

J Deutsche Derma Gesell

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Section: Clinical Lettermentioning

confidence: 99%

Dupilumab in eosinophilic cellulitis (Wells’ syndrome) – case report of a potential new treatment option

Traidl

Angela

Kapp

et al. 2021

J Deutsche Derma Gesell

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“…Coxsackieviruses have been linked to a variety of dermatologic entities, such as hand‐foot‐mouth disease, eczema coxsackium, and polymorphic exanthems ranging from a petechial and purpuric eruption to a Gianotti‐Crosti‐like eruption 16‐18 . In addition, there are anecdotal reports of Wells syndrome and papular‐purpuric gloves and socks syndrome associated with Coxsackieviruses 19,20 . However, to the best of our knowledge, panniculitis in the setting of systemic infection because of Coxsackieviruses has not been reported.…”

Section: Discussionmentioning

confidence: 99%

Viral panniculitis in a patient with disseminated opportunistic Enterovirus infection

et al. 2020

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Infection‐induced panniculitis has been described in association with a broad range of microorganisms. Among those, viral panniculitis represents a minor category, with only a few anecdotal reports in the literature documenting viral infection in the subcutaneous fat. Herein, we report a woman in her 30s with seropositive rheumatoid arthritis on rituximab and prednisone, who presented with a 6‐month history of progressive multisystem manifestations, including unintentional weight loss, fever, fatigue, myopathy, pancreatitis, and sensorineural hearing loss. She had indurated plaques on her thighs characterized by predominantly lobular panniculitis with chronic lymphohistiocytic inflammation. Molecular studies performed at the Centers for Disease Control and Prevention identified evidence of Enterovirus group with the highest identity of Coxsackievirus A9. Enterovirus RNA was also detected in the cerebrospinal fluid and muscle. Based on the findings, a diagnosis of disseminated enteroviral infection in the setting of B‐cell depletion was rendered. To the best of our knowledge, this represents the first reported case of viral panniculitis with documentation of Coxsackievirus A9 in the skin. Since rituximab may be used for the treatment of autoimmune dermatological diseases, familiarity of the potential occurrence of severe enteroviral infections in the setting of immunosuppressive treatment is important for dermatopathologists.

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Wells syndrome as a presenting sign of COVID-19 in the setting of allergic rhinitis and iron deficiency anemia

Yang¹,

Mathieu²,

Elco³

et al. 2022

JAAD Case Reports

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Wells' Syndrome Associated with Coxsackievirus A6 Infection

Cited by 4 publications

References 12 publications

Dupilumab in eosinophilic cellulitis (Wells’ syndrome) – case report of a potential new treatment option

Dupilumab in eosinophilic cellulitis (Wells’ syndrome) – case report of a potential new treatment option

Viral panniculitis in a patient with disseminated opportunistic Enterovirus infection

Wells syndrome as a presenting sign of COVID-19 in the setting of allergic rhinitis and iron deficiency anemia

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