Wells’ Syndrome Associated with Chronic Myeloid Leukaemia

Canine acute eosinophilic dermatitis with oedema (Wells‐like syndrome) associated with T‐cell multicentric lymphoma

“…Although it was impossible to confirm a causal relation in a definitive manner in the present case, the following reasons make it likely that the relapsing multicentric lymphoma acted as a trigger for the onset of CAEDO: (1) correlation between the onset of the dermatologic signs and relapse of the lymphoma; (2) significant cutaneous improvement with the chemotherapy treatment that was contemporaneous with the reinduction of remission from the lymphoma and (3) suspected link between EC (which is a similar condition to CAEDO) and lymphoma in human literature. Notably, as with several reports in people,22 24 26 28 29 31 33 the patient’s skin lesions only seemed to improve following treatment of the malignancy, with complete clinical cure achieved after six weeks on lomustine chemotherapy. Although confirming it is impossible, the authors speculate whether this observation could help explaining the lack of response to glucocorticoid therapy noticed early in this case, as trigger‐focused therapy would be needed to observe clinical improvement.…”

“…However, in human medicine, there are multiple reports associating EC with non‐haematological and haematological malignancies (table 1). In the majority of these cases (10/15), clinical signs of EC preceded the initial diagnosis of the neoplastic process,22–31 diagnosis of metastasis32 or diagnosis of relapse of malignancy 30…”

Wells syndrome associated with chronic lymphocytic leukemia

“…In view of the diversity of triggering factors and possible association with severe diseases like lymphoproliferative disorders, systemic vasculitides and neoplasms, a thorough clinical evaluation of the patients becomes mandatory. 3 , 7 , 10 …”

Case of Wells’ syndrome: A rare association with the clinical course of chronic lymphocytic leukemia

“…Wells' syndrome has been reported to be associated with hematological malignancies. 4 Most cases had developed Wells' syndrome independent of the clinical course of CLL. 5 However, one case, who had developed Wells' syndrome before the diagnosis of CLL, had similar cutaneous manifestations to that of our case.…”